ID   MTX1_DROME              Reviewed;         327 AA.
AC   Q9VHB6;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 150.
DE   RecName: Full=Metaxin-1 homolog;
DE   AltName: Full=Mitochondrial outer membrane import complex protein 1;
GN   ORFNames=CG9393;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC   -!- FUNCTION: Involved in transport of proteins into the mitochondrion.
CC       Essential for embryonic development (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associates with the mitochondrial contact site and cristae
CC       organizing system (MICOS) complex (also known as MINOS or MitOS
CC       complex). {ECO:0000250|UniProtKB:Q13505}.
CC   -!- INTERACTION:
CC       Q9VHB6; Q8T4F2: Dmel\CG5662; NbExp=4; IntAct=EBI-158722, EBI-133471;
CC       Q9VHB6; Q9VW58: Dmel\CG8004; NbExp=4; IntAct=EBI-158722, EBI-124763;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the metaxin family. {ECO:0000305}.
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DR   EMBL; AE014297; AAF54402.1; -; Genomic_DNA.
DR   EMBL; AY051682; AAK93106.1; -; mRNA.
DR   RefSeq; NP_649908.1; NM_141651.3.
DR   AlphaFoldDB; Q9VHB6; -.
DR   SMR; Q9VHB6; -.
DR   BioGRID; 66311; 3.
DR   DIP; DIP-23833N; -.
DR   IntAct; Q9VHB6; 3.
DR   STRING; 7227.FBpp0081591; -.
DR   PaxDb; Q9VHB6; -.
DR   PRIDE; Q9VHB6; -.
DR   DNASU; 41152; -.
DR   EnsemblMetazoa; FBtr0082113; FBpp0081591; FBgn0037710.
DR   GeneID; 41152; -.
DR   KEGG; dme:Dmel_CG9393; -.
DR   UCSC; CG9393-RA; d. melanogaster.
DR   FlyBase; FBgn0037710; CG9393.
DR   VEuPathDB; VectorBase:FBgn0037710; -.
DR   eggNOG; KOG3028; Eukaryota.
DR   GeneTree; ENSGT00950000182919; -.
DR   InParanoid; Q9VHB6; -.
DR   PhylomeDB; Q9VHB6; -.
DR   BioGRID-ORCS; 41152; 1 hit in 3 CRISPR screens.
DR   GenomeRNAi; 41152; -.
DR   PRO; PR:Q9VHB6; -.
DR   Proteomes; UP000000803; Chromosome 3R.
DR   Bgee; FBgn0037710; Expressed in testis and 27 other tissues.
DR   ExpressionAtlas; Q9VHB6; baseline and differential.
DR   Genevisible; Q9VHB6; DM.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IDA:FlyBase.
DR   GO; GO:0001401; C:SAM complex; ISS:FlyBase.
DR   GO; GO:0070096; P:mitochondrial outer membrane translocase complex assembly; ISS:FlyBase.
DR   GO; GO:0007005; P:mitochondrion organization; IBA:GO_Central.
DR   GO; GO:0045040; P:protein insertion into mitochondrial outer membrane; ISS:FlyBase.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR017410; Metaxin1/3.
DR   InterPro; IPR033468; Metaxin_GST.
DR   InterPro; IPR019564; Sam37/metaxin_N.
DR   Pfam; PF17171; GST_C_6; 1.
DR   Pfam; PF10568; Tom37; 1.
DR   PIRSF; PIRSF038150; Metaxin; 1.
DR   SUPFAM; SSF47616; SSF47616; 1.
PE   1: Evidence at protein level;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..327
FT                   /note="Metaxin-1 homolog"
FT                   /id="PRO_0000220994"
FT   TRANSMEM        281..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   327 AA;  37252 MW;  83F68B28AFE6B0A2 CRC64;
     MEMQLGAMLY VYKGEYGLPS IDFECLRALC LLRFTRCPMD VQTSSNPLRS GAGKLPYLQI
     GNQKFAGYRQ IKRVLDLEGY PIDAHLSTKQ KHLSTAYANW VFTNLHAYYH YFLFGEPHNF
     DTTTRGLYAK RTPFPFNFYY PSSYQREACD VVQVMAGFDV NDKLDKHEGD YLVVNAKKVV
     NLLSRKLGRK VWFFGDTYSE FDAIVYSYLA IIFKIALPNN PLQNHIKGCQ NLVNFINRIT
     KDIFRIEGYS SVKLTKTPSG TEASLTASER KFLDSELNTK IVAGVGAVLA MGAFAAWRGI
     YNQLTTRSST DYDGIDYEDD EMEEGLD