ID   MTX1_SCHPO              Reviewed;         271 AA.
AC   Q9HE00;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Metaxin-1;
GN   Name=mtx1; ORFNames=SPAC589.04;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Involved in transport of proteins into the mitochondrion.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Associates with the MINOS/MitOS complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the metaxin family. {ECO:0000305}.
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DR   EMBL; CU329670; CAC19761.1; -; Genomic_DNA.
DR   RefSeq; NP_594052.1; NM_001019476.2.
DR   AlphaFoldDB; Q9HE00; -.
DR   SMR; Q9HE00; -.
DR   BioGRID; 279077; 1.
DR   STRING; 4896.SPAC589.04.1; -.
DR   MaxQB; Q9HE00; -.
DR   PaxDb; Q9HE00; -.
DR   EnsemblFungi; SPAC589.04.1; SPAC589.04.1:pep; SPAC589.04.
DR   GeneID; 2542623; -.
DR   KEGG; spo:SPAC589.04; -.
DR   PomBase; SPAC589.04; mtx1.
DR   VEuPathDB; FungiDB:SPAC589.04; -.
DR   eggNOG; KOG3028; Eukaryota.
DR   HOGENOM; CLU_1062294_0_0_1; -.
DR   InParanoid; Q9HE00; -.
DR   OMA; YSMYLDE; -.
DR   PhylomeDB; Q9HE00; -.
DR   PRO; PR:Q9HE00; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0001401; C:SAM complex; ISO:PomBase.
DR   GO; GO:0007005; P:mitochondrion organization; IBA:GO_Central.
DR   GO; GO:0045040; P:protein insertion into mitochondrial outer membrane; ISO:PomBase.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR033468; Metaxin_GST.
DR   InterPro; IPR012336; Thioredoxin-like_fold.
DR   Pfam; PF17171; GST_C_6; 1.
DR   Pfam; PF17172; GST_N_4; 1.
DR   SUPFAM; SSF47616; SSF47616; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..271
FT                   /note="Metaxin-1"
FT                   /id="PRO_0000350818"
SQ   SEQUENCE   271 AA;  30897 MW;  494509AE388A230C CRC64;
     MGGLTKFSSY FHSIFSRFPL ITFSNPYPGE NEDYKTKTVM YLTMWNSDLN SEALDVNSLQ
     WQTWAKLNDP SIVFLNVSNH ASPDEKVPFI QIESRKLVLN PSLLQYFLKD ESTLQQISPW
     MSLLINQVET AILLTMYLDN ENFSEIQKKW LPNMSWPLNI IKSIGLPSQI KRKICLQLNE
     STLDFDAILE DASKAFSALS ELLGSDKWFF NNESPSFLDV SLFAHAEIIN HLPLKNDQLK
     VVLGTHKNLT DLTTRVRTLA GYTSAGPIAL R