ID   MTX2_PIG                Reviewed;         267 AA.
AC   Q2L969;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Metaxin-2;
DE   AltName: Full=Mitochondrial outer membrane import complex protein 2;
GN   Name=MTX2;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Intestine;
RA   Adolph K.W.;
RT   "Sus scrofa metaxin 2: cDNA and protein structure.";
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in transport of proteins into the mitochondrion.
CC       {ECO:0000250|UniProtKB:O75431}.
CC   -!- SUBUNIT: Interacts with MTX1/metaxin-1. Associates with the
CC       mitochondrial contact site and cristae organizing system (MICOS)
CC       complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19,
CC       CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13.
CC       This complex was also known under the names MINOS or MitOS complex. The
CC       MICOS complex associates with mitochondrial outer membrane proteins
CC       SAMM50, MTX1 and MTX2 (together described as components of the
CC       mitochondrial outer membrane sorting assembly machinery (SAM) complex)
CC       and DNAJC11, mitochondrial inner membrane protein TMEM11 and with
CC       HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a
CC       large protein complex spanning both membranes termed the mitochondrial
CC       intermembrane space bridging (MIB) complex.
CC       {ECO:0000250|UniProtKB:O75431}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000250|UniProtKB:O75431}. Mitochondrion
CC       {ECO:0000250|UniProtKB:O75431}.
CC   -!- SIMILARITY: Belongs to the metaxin family. {ECO:0000305}.
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DR   EMBL; DQ345906; ABC71323.1; -; mRNA.
DR   RefSeq; NP_001038006.1; NM_001044541.1.
DR   AlphaFoldDB; Q2L969; -.
DR   SMR; Q2L969; -.
DR   STRING; 9823.ENSSSCP00000027271; -.
DR   PaxDb; Q2L969; -.
DR   PeptideAtlas; Q2L969; -.
DR   PRIDE; Q2L969; -.
DR   Ensembl; ENSSSCT00005036266; ENSSSCP00005022131; ENSSSCG00005022927.
DR   Ensembl; ENSSSCT00030081063; ENSSSCP00030037177; ENSSSCG00030058011.
DR   Ensembl; ENSSSCT00055008095; ENSSSCP00055006412; ENSSSCG00055004078.
DR   Ensembl; ENSSSCT00070034084; ENSSSCP00070028461; ENSSSCG00070017288.
DR   GeneID; 733591; -.
DR   KEGG; ssc:733591; -.
DR   CTD; 10651; -.
DR   eggNOG; KOG3027; Eukaryota.
DR   HOGENOM; CLU_044137_6_0_1; -.
DR   InParanoid; Q2L969; -.
DR   OMA; PWPENAA; -.
DR   OrthoDB; 1219712at2759; -.
DR   TreeFam; TF313422; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Chromosome 15.
DR   Genevisible; Q2L969; SS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0001401; C:SAM complex; IBA:GO_Central.
DR   GO; GO:0006839; P:mitochondrial transport; ISS:UniProtKB.
DR   GO; GO:0007005; P:mitochondrion organization; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR040079; Glutathione_S-Trfase.
DR   InterPro; IPR033468; Metaxin_GST.
DR   InterPro; IPR019564; Sam37/metaxin_N.
DR   Pfam; PF17171; GST_C_6; 1.
DR   Pfam; PF10568; Tom37; 1.
DR   SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR   SUPFAM; SSF47616; SSF47616; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Protein transport; Reference proteome; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:O75431"
FT   CHAIN           2..267
FT                   /note="Metaxin-2"
FT                   /id="PRO_0000227748"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:O75431"
SQ   SEQUENCE   267 AA;  30106 MW;  1FA7833D50673B89 CRC64;
     MSLVAEAFVS QIAAAEPWPE NATLYQQLKG EQILLSDNAA SLAVQAFLQM CNLPIKVVCR
     ANAEYMSPSG KVPFIHVGNQ VVSELGPIVQ FVKAKGHSLS DGLDEVQKAE MKAYMELVNN
     MLLTAELYLQ WCDEATVGEI THARYGSPYP WPLNHILAYQ KQWEVKRKMK AIGWGNKTLD
     QVLEDVDQCC QALSQRLGTQ PYFFNKQPTE LDALVFGHLY TILTTQLTND ELSEKVKNYS
     NLLAFCRRIE QHYFEDHSKG SSSVRLS