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MTX3_DANRE
ID   MTX3_DANRE              Reviewed;         313 AA.
AC   Q4VBW0; Q6Y0L8;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Metaxin-3;
DE            Short=zMTX3;
GN   Name=mtx3; ORFNames=zgc:109718;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=AB;
RX   PubMed=15087125; DOI=10.1016/j.gene.2004.01.005;
RA   Adolph K.W.;
RT   "The zebrafish metaxin 3 gene (mtx3): cDNA and protein structure, and
RT   comparison to zebrafish metaxins 1 and 2.";
RL   Gene 330:67-73(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Could function in transport of proteins into the
CC       mitochondrion. {ECO:0000250}.
CC   -!- SUBUNIT: Part of a large protein complex spanning both mitochondrial
CC       membranes termed the mitochondrial intermembrane space bridging (MIB)
CC       complex. {ECO:0000250|UniProtKB:Q5HYI7}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q5HYI7}.
CC       Mitochondrion outer membrane {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the metaxin family. {ECO:0000305}.
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DR   EMBL; AY194226; AAO23008.1; -; mRNA.
DR   EMBL; BC094962; AAH94962.1; -; mRNA.
DR   RefSeq; NP_991184.1; NM_205621.1.
DR   AlphaFoldDB; Q4VBW0; -.
DR   SMR; Q4VBW0; -.
DR   STRING; 7955.ENSDARP00000030405; -.
DR   PaxDb; Q4VBW0; -.
DR   GeneID; 402916; -.
DR   KEGG; dre:402916; -.
DR   CTD; 345778; -.
DR   ZFIN; ZDB-GENE-021210-3; mtx3.
DR   eggNOG; KOG3028; Eukaryota.
DR   InParanoid; Q4VBW0; -.
DR   OrthoDB; 1472286at2759; -.
DR   PhylomeDB; Q4VBW0; -.
DR   TreeFam; TF313422; -.
DR   PRO; PR:Q4VBW0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0001401; C:SAM complex; IBA:GO_Central.
DR   GO; GO:0007005; P:mitochondrion organization; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR040079; Glutathione_S-Trfase.
DR   InterPro; IPR017410; Metaxin1/3.
DR   InterPro; IPR033468; Metaxin_GST.
DR   InterPro; IPR019564; Sam37/metaxin_N.
DR   Pfam; PF17171; GST_C_6; 1.
DR   Pfam; PF10568; Tom37; 1.
DR   PIRSF; PIRSF038150; Metaxin; 1.
DR   SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR   SUPFAM; SSF47616; SSF47616; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..313
FT                   /note="Metaxin-3"
FT                   /id="PRO_0000337101"
FT   REGION          280..313
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..303
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        131
FT                   /note="P -> L (in Ref. 1; AAO23008)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        241
FT                   /note="F -> L (in Ref. 1; AAO23008)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        260
FT                   /note="P -> F (in Ref. 2; AAH94962)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   313 AA;  35227 MW;  D8C536822A61A820 CRC64;
     MAEPIELLCW GGDWDLPSVQ TDSLTVLAYA KFAGAELTVK FVDWTWRTIT ASVPQIHYEG
     TTVTEPTQIL NFLRKQRFNA DFELTAKQGA DTMAYIALLE EKLRPALLHT FWVDAENYAN
     LTRPWFTSHS PFPLNFFVPG RQASLALSRI LLTKAESPLL NITEVEGKIY SEAKECLNLL
     SHRLGNFNFF FGDTPTSLDA FVFGHIAPLI KAPLPSGQLQ KHLNQLDNLC QFCNTILKNY
     FTDATAEKRM DCSPTVAHDP VDANLQKLTQ LVNKESNLIE KMDDNLRSSP QHRPHRHEAK
     PSAPASDRNS TPA
 
 
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