MTX3_DANRE
ID MTX3_DANRE Reviewed; 313 AA.
AC Q4VBW0; Q6Y0L8;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Metaxin-3;
DE Short=zMTX3;
GN Name=mtx3; ORFNames=zgc:109718;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=AB;
RX PubMed=15087125; DOI=10.1016/j.gene.2004.01.005;
RA Adolph K.W.;
RT "The zebrafish metaxin 3 gene (mtx3): cDNA and protein structure, and
RT comparison to zebrafish metaxins 1 and 2.";
RL Gene 330:67-73(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Could function in transport of proteins into the
CC mitochondrion. {ECO:0000250}.
CC -!- SUBUNIT: Part of a large protein complex spanning both mitochondrial
CC membranes termed the mitochondrial intermembrane space bridging (MIB)
CC complex. {ECO:0000250|UniProtKB:Q5HYI7}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q5HYI7}.
CC Mitochondrion outer membrane {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the metaxin family. {ECO:0000305}.
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DR EMBL; AY194226; AAO23008.1; -; mRNA.
DR EMBL; BC094962; AAH94962.1; -; mRNA.
DR RefSeq; NP_991184.1; NM_205621.1.
DR AlphaFoldDB; Q4VBW0; -.
DR SMR; Q4VBW0; -.
DR STRING; 7955.ENSDARP00000030405; -.
DR PaxDb; Q4VBW0; -.
DR GeneID; 402916; -.
DR KEGG; dre:402916; -.
DR CTD; 345778; -.
DR ZFIN; ZDB-GENE-021210-3; mtx3.
DR eggNOG; KOG3028; Eukaryota.
DR InParanoid; Q4VBW0; -.
DR OrthoDB; 1472286at2759; -.
DR PhylomeDB; Q4VBW0; -.
DR TreeFam; TF313422; -.
DR PRO; PR:Q4VBW0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0001401; C:SAM complex; IBA:GO_Central.
DR GO; GO:0007005; P:mitochondrion organization; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR017410; Metaxin1/3.
DR InterPro; IPR033468; Metaxin_GST.
DR InterPro; IPR019564; Sam37/metaxin_N.
DR Pfam; PF17171; GST_C_6; 1.
DR Pfam; PF10568; Tom37; 1.
DR PIRSF; PIRSF038150; Metaxin; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SUPFAM; SSF47616; SSF47616; 1.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion outer membrane; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..313
FT /note="Metaxin-3"
FT /id="PRO_0000337101"
FT REGION 280..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..303
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 131
FT /note="P -> L (in Ref. 1; AAO23008)"
FT /evidence="ECO:0000305"
FT CONFLICT 241
FT /note="F -> L (in Ref. 1; AAO23008)"
FT /evidence="ECO:0000305"
FT CONFLICT 260
FT /note="P -> F (in Ref. 2; AAH94962)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 313 AA; 35227 MW; D8C536822A61A820 CRC64;
MAEPIELLCW GGDWDLPSVQ TDSLTVLAYA KFAGAELTVK FVDWTWRTIT ASVPQIHYEG
TTVTEPTQIL NFLRKQRFNA DFELTAKQGA DTMAYIALLE EKLRPALLHT FWVDAENYAN
LTRPWFTSHS PFPLNFFVPG RQASLALSRI LLTKAESPLL NITEVEGKIY SEAKECLNLL
SHRLGNFNFF FGDTPTSLDA FVFGHIAPLI KAPLPSGQLQ KHLNQLDNLC QFCNTILKNY
FTDATAEKRM DCSPTVAHDP VDANLQKLTQ LVNKESNLIE KMDDNLRSSP QHRPHRHEAK
PSAPASDRNS TPA