ID   MTXH_METAC              Reviewed;         310 AA.
AC   Q8TPV0;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-JAN-2004, sequence version 2.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Putative methyltransferase mtx subunit H;
DE            EC=2.1.1.-;
GN   Name=mtxH; OrderedLocusNames=MA_1804;
OS   Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS   C2A).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=188937;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
RX   PubMed=11932238; DOI=10.1101/gr.223902;
RA   Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA   Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA   Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA   McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA   Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R.,
RA   Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J.,
RA   Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A.,
RA   White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H.,
RA   Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V.,
RA   Zinder S.H., Lander E., Metcalf W.W., Birren B.;
RT   "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT   physiological diversity.";
RL   Genome Res. 12:532-542(2002).
CC   -!- SUBUNIT: May be part of a complex composed of 3 subunits; MtxA, MtxH
CC       and MtxX. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MtrH family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM05210.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE010299; AAM05210.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_011021807.1; NC_003552.1.
DR   AlphaFoldDB; Q8TPV0; -.
DR   SMR; Q8TPV0; -.
DR   STRING; 188937.MA_1804; -.
DR   EnsemblBacteria; AAM05210; AAM05210; MA_1804.
DR   GeneID; 1473693; -.
DR   KEGG; mac:MA_1804; -.
DR   HOGENOM; CLU_048697_0_0_2; -.
DR   InParanoid; Q8TPV0; -.
DR   OMA; NAPSAWN; -.
DR   OrthoDB; 86442at2157; -.
DR   PhylomeDB; Q8TPV0; -.
DR   Proteomes; UP000002487; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:InterPro.
DR   InterPro; IPR011005; Dihydropteroate_synth-like.
DR   InterPro; IPR023467; MeTrfase_MtrH/MtxH.
DR   InterPro; IPR028342; MtrH.
DR   Pfam; PF02007; MtrH; 1.
DR   PIRSF; PIRSF500206; MtrH; 1.
DR   PIRSF; PIRSF004960; MtrH_MtxH; 1.
DR   SUPFAM; SSF51717; SSF51717; 1.
DR   TIGRFAMs; TIGR01114; mtrH; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..310
FT                   /note="Putative methyltransferase mtx subunit H"
FT                   /id="PRO_0000147569"
SQ   SEQUENCE   310 AA;  33598 MW;  E33621D57D9E1DFA CRC64;
     MFKFQKEQEI ANIAGIKVGG QPGELPTLLA GTIFYNKHEI VEDAAKGLFD RIAAEKLVNL
     QEVGSDMTGN PHMVHIFGTT QESITRYIDF IAEVSESPFL IDSPEGTVRA HASRYVSEIG
     LADRAVYNSI NMSITTSEIE ALAQSDIDSS IILGFNAMDS SLRGRMEMLE TGAGLLEEGL
     LSIADRCGIV NKLIDPSITP MGNGAGIALR MTITAKAKWG YPTGSGIHNA PSAWNWLNRQ
     KEKNPVLYKI CDVGSTCLQQ AAAGDFILYG PIEYAQYVFP MAAMSDIMIA EAVADLDIEP
     ASRHPINLLV