ID   MTXH_METBF              Reviewed;         310 AA.
AC   O32855; Q46AT9;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Putative methyltransferase mtx subunit H;
DE            EC=2.1.1.-;
GN   Name=mtxH; OrderedLocusNames=Mbar_A2072;
OS   Methanosarcina barkeri (strain Fusaro / DSM 804).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=269797;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9461302; DOI=10.1111/j.1432-1033.1997.00783.x;
RA   Harms U., Thauer R.K.;
RT   "Identification of the active site histidine in the corrinoid protein MtrA
RT   of the energy-conserving methyltransferase complex from Methanobacterium
RT   thermoautotrophicum.";
RL   Eur. J. Biochem. 250:783-788(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Fusaro / DSM 804;
RX   PubMed=16980466; DOI=10.1128/jb.00810-06;
RA   Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S.,
RA   Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R.;
RT   "The Methanosarcina barkeri genome: comparative analysis with
RT   Methanosarcina acetivorans and Methanosarcina mazei reveals extensive
RT   rearrangement within methanosarcinal genomes.";
RL   J. Bacteriol. 188:7922-7931(2006).
CC   -!- SUBUNIT: May be part of a complex composed of 3 subunits; MtxA, MtxH
CC       and MtxX.
CC   -!- SIMILARITY: Belongs to the MtrH family. {ECO:0000305}.
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DR   EMBL; Y14612; CAA74964.1; -; Genomic_DNA.
DR   EMBL; CP000099; AAZ71003.1; -; Genomic_DNA.
DR   RefSeq; WP_011307049.1; NC_007355.1.
DR   AlphaFoldDB; O32855; -.
DR   SMR; O32855; -.
DR   STRING; 269797.Mbar_A2072; -.
DR   EnsemblBacteria; AAZ71003; AAZ71003; Mbar_A2072.
DR   GeneID; 3626466; -.
DR   KEGG; mba:Mbar_A2072; -.
DR   eggNOG; arCOG04336; Archaea.
DR   HOGENOM; CLU_048697_0_0_2; -.
DR   OMA; NAPSAWN; -.
DR   OrthoDB; 86442at2157; -.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:InterPro.
DR   InterPro; IPR011005; Dihydropteroate_synth-like.
DR   InterPro; IPR023467; MeTrfase_MtrH/MtxH.
DR   InterPro; IPR028342; MtrH.
DR   Pfam; PF02007; MtrH; 1.
DR   PIRSF; PIRSF500206; MtrH; 1.
DR   PIRSF; PIRSF004960; MtrH_MtxH; 1.
DR   SUPFAM; SSF51717; SSF51717; 1.
DR   TIGRFAMs; TIGR01114; mtrH; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Transferase.
FT   CHAIN           1..310
FT                   /note="Putative methyltransferase mtx subunit H"
FT                   /id="PRO_0000147570"
SQ   SEQUENCE   310 AA;  33431 MW;  3C6147A18ACCFF99 CRC64;
     MFKFQKEQEI VNIAGVKIGG QPGELPTVLA GTIFYDKHEI VKDVARGLFD RDAAEKLINL
     QESSAEETGN PYIIHIFGTT PESITRYIDF VAEISEAPFL IDSPEGTVRS HAAEYVSEIG
     LADKAIYNSI NMSINASEIE ALALSDIDSS IILGFNAMDS SLQGRMEMLE NGAGLLEEGL
     LSIADRCGIV NKLIDPSITP MGNGAGVALK MTITAKAKWG HPTGSGIHNA PSAWNWLNKK
     KEKDPVLYKI CDVGSTCLQQ AAAGDFILYG PIEYAPYIFP MAAMSDIMIS EAVADLGIEP
     ASRHPLNLLV