ID   MT_AGABI                Reviewed;          25 AA.
AC   P04358;
DT   20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-1987, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=Metallothionein;
DE            Short=MT;
OS   Agaricus bisporus (White button mushroom).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Agaricaceae; Agaricus.
OX   NCBI_TaxID=5341;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   STRAIN=A-32; TISSUE=Mycelium;
RA   Muenger K., Lerch K.;
RT   "Copper metallothionein from the fungus Agaricus bisporus: chemical and
RT   spectroscopic properties.";
RL   Biochemistry 24:6751-6756(1985).
CC   -!- FUNCTION: The metallothioneins are involved in the cellular
CC       sequestration of toxic metal ions. Binds six copper (cuprous) ions.
CC   -!- MISCELLANEOUS: The absorption, luminescent, and stereo-optical
CC       properties of the copper MT are attributed to the metal-thiolate
CC       complex because they are not present in the apoprotein.
CC   -!- SIMILARITY: Belongs to the metallothionein superfamily. Type 8 family.
CC       {ECO:0000305}.
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DR   PIR; A03286; SMMR.
DR   AlphaFoldDB; P04358; -.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Copper; Direct protein sequencing; Metal-binding; Metal-thiolate cluster.
FT   PEPTIDE         1..25
FT                   /note="Metallothionein"
FT                   /id="PRO_0000197361"
FT   BINDING         3
FT                   /ligand="Cu(+)"
FT                   /ligand_id="ChEBI:CHEBI:49552"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P02807"
FT   BINDING         5
FT                   /ligand="Cu(+)"
FT                   /ligand_id="ChEBI:CHEBI:49552"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P02807"
FT   BINDING         5
FT                   /ligand="Cu(+)"
FT                   /ligand_id="ChEBI:CHEBI:49552"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000250|UniProtKB:P02807"
FT   BINDING         11
FT                   /ligand="Cu(+)"
FT                   /ligand_id="ChEBI:CHEBI:49552"
FT                   /ligand_label="4"
FT                   /evidence="ECO:0000250|UniProtKB:P02807"
FT   BINDING         11
FT                   /ligand="Cu(+)"
FT                   /ligand_id="ChEBI:CHEBI:49552"
FT                   /ligand_label="5"
FT                   /evidence="ECO:0000250|UniProtKB:P02807"
FT   BINDING         13
FT                   /ligand="Cu(+)"
FT                   /ligand_id="ChEBI:CHEBI:49552"
FT                   /ligand_label="6"
FT                   /evidence="ECO:0000250|UniProtKB:P02807"
FT   BINDING         18
FT                   /ligand="Cu(+)"
FT                   /ligand_id="ChEBI:CHEBI:49552"
FT                   /ligand_label="5"
FT                   /evidence="ECO:0000250|UniProtKB:P02807"
FT   BINDING         18
FT                   /ligand="Cu(+)"
FT                   /ligand_id="ChEBI:CHEBI:49552"
FT                   /ligand_label="6"
FT                   /evidence="ECO:0000250|UniProtKB:P02807"
FT   BINDING         20
FT                   /ligand="Cu(+)"
FT                   /ligand_id="ChEBI:CHEBI:49552"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000250|UniProtKB:P02807"
FT   BINDING         20
FT                   /ligand="Cu(+)"
FT                   /ligand_id="ChEBI:CHEBI:49552"
FT                   /ligand_label="4"
FT                   /evidence="ECO:0000250|UniProtKB:P02807"
FT   BINDING         23
FT                   /ligand="Cu(+)"
FT                   /ligand_id="ChEBI:CHEBI:49552"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P02807"
FT   BINDING         23
FT                   /ligand="Cu(+)"
FT                   /ligand_id="ChEBI:CHEBI:49552"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P02807"
SQ   SEQUENCE   25 AA;  2233 MW;  33AB70F21023CFF7 CRC64;
     GDCGCSGASS CTCASGQCTC SGCGK