MU122_SCHPO
ID MU122_SCHPO Reviewed; 749 AA.
AC O74444;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Meiotically up-regulated gene 122 protein;
GN Name=mug122; ORFNames=SPCC1682.15;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION IN MEIOSIS.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes required for
RT critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Has a role in meiosis. {ECO:0000269|PubMed:16303567}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:16823372}; Single-pass type II membrane protein
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the sorting nexin family. {ECO:0000305}.
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DR EMBL; CU329672; CAA20681.1; -; Genomic_DNA.
DR PIR; T41072; T41072.
DR RefSeq; NP_587808.1; NM_001022801.2.
DR AlphaFoldDB; O74444; -.
DR BioGRID; 275805; 29.
DR STRING; 4896.SPCC1682.15.1; -.
DR iPTMnet; O74444; -.
DR MaxQB; O74444; -.
DR PaxDb; O74444; -.
DR PRIDE; O74444; -.
DR EnsemblFungi; SPCC1682.15.1; SPCC1682.15.1:pep; SPCC1682.15.
DR GeneID; 2539235; -.
DR KEGG; spo:SPCC1682.15; -.
DR PomBase; SPCC1682.15; mug122.
DR VEuPathDB; FungiDB:SPCC1682.15; -.
DR eggNOG; ENOG502RM76; Eukaryota.
DR HOGENOM; CLU_371373_0_0_1; -.
DR InParanoid; O74444; -.
DR OMA; VNRCIIL; -.
DR PRO; PR:O74444; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0035091; F:phosphatidylinositol binding; ISM:PomBase.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR Gene3D; 3.30.1520.10; -; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR013937; Sorting_nexin_C.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR SMART; SM00313; PXA; 1.
DR SUPFAM; SSF64268; SSF64268; 1.
DR PROSITE; PS51207; PXA; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; Meiosis; Membrane; Reference proteome;
KW Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..749
FT /note="Meiotically up-regulated gene 122 protein"
FT /id="PRO_0000278572"
FT TOPO_DOM 1..20
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 21..41
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 42..749
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT DOMAIN 88..261
FT /note="PXA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00553"
FT DOMAIN 311..422
FT /note="PX"
FT REGION 439..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 504..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 749 AA; 85641 MW; 9444DA3B14E863CE CRC64;
MYRKWDLCIT RHLLPYIEHS VIPIIALLVL SLIFYILYIC FGTTSYILSG IILGAYVNSL
FHNNHSVILN IKHPELGEPL KPYQTPLPPE LEAPLQLLIS KLTQHYINGW YKHVSEDPSF
IREVQSTIEY IMRQFYAYVS SQESSHIIYE LLKNAISTTT LVLSDLNHFR SKKIPLTEFA
LRYPESAVSK LLDQASIERT LRAQASAMIV KFSRPEDSAC LPLHCLLREV LAMQVFKRIT
THCSSPRFVN RCIILYFSSS EDKSDCLAKK NYVNKCLMAK ALKDYPVHTN IDPDAGKLSF
DDAFYEAHIE LHYQFLKEAS LNTLIKDKKM LKFIITVRPV HLHVSPWVVY RRYRGFKTLY
YLLKKQSARN GRAVPSFPVW RGNTYEKFRE GLYFFIEALL HDSHFATNVD VRKFFAKSMR
SHPLVDDIYN GFDVDKKHQS SSVPTLPNLT NISRVLSNKT SKSAKPKRSE RTGLLSHQST
LAPEPLSQQR DSFELCTTGY RDTGSCTSDD EDSIHEPYRP ASTQPTENPP AMPDHNGSPT
TEPPKPNAFE LKEERLKEII SGGFALVDEL CSLNSKLWFF RKSVLTIMKT TVLHGPGRFS
AQVERMLKNQ IYDKLSNTQL VGDLLTSLIL NVWPDEKKAM ESHSTRAHRR STESKISFDS
EADSLFEEAS KSVPEDPVSV FCDEESDESL RLRAEKTLVE NALSENFTLM LGQSTSEESL
KIIFELLQEP QFVQGFLAHL LSNALRSII