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MU122_SCHPO
ID   MU122_SCHPO             Reviewed;         749 AA.
AC   O74444;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=Meiotically up-regulated gene 122 protein;
GN   Name=mug122; ORFNames=SPCC1682.15;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   FUNCTION IN MEIOSIS.
RX   PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA   Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA   Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA   Smith G.R., Moreno S.;
RT   "A large-scale screen in S. pombe identifies seven novel genes required for
RT   critical meiotic events.";
RL   Curr. Biol. 15:2056-2062(2005).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Has a role in meiosis. {ECO:0000269|PubMed:16303567}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000269|PubMed:16823372}; Single-pass type II membrane protein
CC       {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the sorting nexin family. {ECO:0000305}.
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DR   EMBL; CU329672; CAA20681.1; -; Genomic_DNA.
DR   PIR; T41072; T41072.
DR   RefSeq; NP_587808.1; NM_001022801.2.
DR   AlphaFoldDB; O74444; -.
DR   BioGRID; 275805; 29.
DR   STRING; 4896.SPCC1682.15.1; -.
DR   iPTMnet; O74444; -.
DR   MaxQB; O74444; -.
DR   PaxDb; O74444; -.
DR   PRIDE; O74444; -.
DR   EnsemblFungi; SPCC1682.15.1; SPCC1682.15.1:pep; SPCC1682.15.
DR   GeneID; 2539235; -.
DR   KEGG; spo:SPCC1682.15; -.
DR   PomBase; SPCC1682.15; mug122.
DR   VEuPathDB; FungiDB:SPCC1682.15; -.
DR   eggNOG; ENOG502RM76; Eukaryota.
DR   HOGENOM; CLU_371373_0_0_1; -.
DR   InParanoid; O74444; -.
DR   OMA; VNRCIIL; -.
DR   PRO; PR:O74444; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0035091; F:phosphatidylinositol binding; ISM:PomBase.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1520.10; -; 1.
DR   InterPro; IPR003114; Phox_assoc.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR013937; Sorting_nexin_C.
DR   Pfam; PF08628; Nexin_C; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF02194; PXA; 1.
DR   SMART; SM00313; PXA; 1.
DR   SUPFAM; SSF64268; SSF64268; 1.
DR   PROSITE; PS51207; PXA; 1.
PE   1: Evidence at protein level;
KW   Endoplasmic reticulum; Meiosis; Membrane; Reference proteome;
KW   Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..749
FT                   /note="Meiotically up-regulated gene 122 protein"
FT                   /id="PRO_0000278572"
FT   TOPO_DOM        1..20
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        21..41
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        42..749
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          88..261
FT                   /note="PXA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00553"
FT   DOMAIN          311..422
FT                   /note="PX"
FT   REGION          439..489
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          504..546
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        439..462
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        473..489
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   749 AA;  85641 MW;  9444DA3B14E863CE CRC64;
     MYRKWDLCIT RHLLPYIEHS VIPIIALLVL SLIFYILYIC FGTTSYILSG IILGAYVNSL
     FHNNHSVILN IKHPELGEPL KPYQTPLPPE LEAPLQLLIS KLTQHYINGW YKHVSEDPSF
     IREVQSTIEY IMRQFYAYVS SQESSHIIYE LLKNAISTTT LVLSDLNHFR SKKIPLTEFA
     LRYPESAVSK LLDQASIERT LRAQASAMIV KFSRPEDSAC LPLHCLLREV LAMQVFKRIT
     THCSSPRFVN RCIILYFSSS EDKSDCLAKK NYVNKCLMAK ALKDYPVHTN IDPDAGKLSF
     DDAFYEAHIE LHYQFLKEAS LNTLIKDKKM LKFIITVRPV HLHVSPWVVY RRYRGFKTLY
     YLLKKQSARN GRAVPSFPVW RGNTYEKFRE GLYFFIEALL HDSHFATNVD VRKFFAKSMR
     SHPLVDDIYN GFDVDKKHQS SSVPTLPNLT NISRVLSNKT SKSAKPKRSE RTGLLSHQST
     LAPEPLSQQR DSFELCTTGY RDTGSCTSDD EDSIHEPYRP ASTQPTENPP AMPDHNGSPT
     TEPPKPNAFE LKEERLKEII SGGFALVDEL CSLNSKLWFF RKSVLTIMKT TVLHGPGRFS
     AQVERMLKNQ IYDKLSNTQL VGDLLTSLIL NVWPDEKKAM ESHSTRAHRR STESKISFDS
     EADSLFEEAS KSVPEDPVSV FCDEESDESL RLRAEKTLVE NALSENFTLM LGQSTSEESL
     KIIFELLQEP QFVQGFLAHL LSNALRSII
 
 
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