ID   MU135_SCHPO             Reviewed;         357 AA.
AC   O74876; Q9US90;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Meiotically up-regulated gene 135 protein;
GN   Name=mug135; ORFNames=SPCC330.04c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 88-258, AND SUBCELLULAR
RP   LOCATION.
RC   STRAIN=ATCC 38364 / 968;
RX   PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA   Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA   Hiraoka Y.;
RT   "Large-scale screening of intracellular protein localization in living
RT   fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL   Genes Cells 5:169-190(2000).
RN   [3]
RP   FUNCTION IN MEIOSIS.
RX   PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA   Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA   Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA   Smith G.R., Moreno S.;
RT   "A large-scale screen in S. pombe identifies seven novel genes required for
RT   critical meiotic events.";
RL   Curr. Biol. 15:2056-2062(2005).
CC   -!- FUNCTION: Has a role in meiosis. {ECO:0000269|PubMed:16303567}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10759889}.
CC   -!- SIMILARITY: Belongs to the UPF0612 family. {ECO:0000305}.
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DR   EMBL; CU329672; CAA20909.1; -; Genomic_DNA.
DR   EMBL; AB027955; BAA87259.1; -; Genomic_DNA.
DR   PIR; T41314; T41314.
DR   RefSeq; NP_587704.1; NM_001022699.2.
DR   AlphaFoldDB; O74876; -.
DR   SMR; O74876; -.
DR   BioGRID; 275541; 7.
DR   STRING; 4896.SPCC330.04c.1; -.
DR   MaxQB; O74876; -.
DR   PaxDb; O74876; -.
DR   PRIDE; O74876; -.
DR   EnsemblFungi; SPCC330.04c.1; SPCC330.04c.1:pep; SPCC330.04c.
DR   GeneID; 2538967; -.
DR   KEGG; spo:SPCC330.04c; -.
DR   PomBase; SPCC330.04c; mug135.
DR   VEuPathDB; FungiDB:SPCC330.04c; -.
DR   eggNOG; ENOG502STX1; Eukaryota.
DR   HOGENOM; CLU_062677_0_0_1; -.
DR   InParanoid; O74876; -.
DR   PhylomeDB; O74876; -.
DR   PRO; PR:O74876; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR013902; DUF1773.
DR   Pfam; PF08593; DUF1773; 1.
PE   1: Evidence at protein level;
KW   Meiosis; Nucleus; Reference proteome.
FT   CHAIN           1..357
FT                   /note="Meiotically up-regulated gene 135 protein"
FT                   /id="PRO_0000278626"
SQ   SEQUENCE   357 AA;  43098 MW;  B81259C97F2C67EC CRC64;
     MSEEDNRLNE LFANDLGVQP PCERSLKEGR RFLNDFEIAA KKKLLELERK ALEDKEKNLN
     FVVESERTLF NSKKRAFDND ECYNDRCKLF RGIVNEWGRS ERTLDSLDEP PAWFRREMGE
     WKKAREEDKA EWKKAREEDK AEWKKAREED KAEWKKAREE DKAEWKKARE EDKAEWKKAR
     EEDKEWRNSM DEWRKSMDEW RKSMDEWRKS MDEWRKSTDE WRKSTDERLE NLLNIVREIL
     DVQRDMRNDL SNLTRKVDRM DMRLSRNNNM IMRSFAQPIT EVPFFNGDIP DPNLPRITRI
     EDIDSLSEEN CTRYLKGYGV SYDENDQSLW KRQLAKAVGL TAAYDESYTF SPFSSSE