MU137_SCHPO
ID MU137_SCHPO Reviewed; 420 AA.
AC O94478;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=Meiotically up-regulated gene 137 protein;
GN Name=mug137; ORFNames=SPCC1919.11;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION IN MEIOSIS.
RX PubMed=12161753; DOI=10.1038/ng951;
RA Mata J., Lyne R., Burns G., Baehler J.;
RT "The transcriptional program of meiosis and sporulation in fission yeast.";
RL Nat. Genet. 32:143-147(2002).
RN [3]
RP FUNCTION IN MEIOSIS/SPORULATION.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes required for
RT critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Has a role in meiosis and sporulation.
CC {ECO:0000269|PubMed:12161753, ECO:0000269|PubMed:16303567}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}. Note=Localizes at the barrier septum.
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DR EMBL; CU329672; CAA22642.1; -; Genomic_DNA.
DR PIR; T41236; T41236.
DR RefSeq; NP_588493.1; NM_001023483.2.
DR AlphaFoldDB; O94478; -.
DR SMR; O94478; -.
DR BioGRID; 275685; 6.
DR STRING; 4896.SPCC1919.11.1; -.
DR PaxDb; O94478; -.
DR EnsemblFungi; SPCC1919.11.1; SPCC1919.11.1:pep; SPCC1919.11.
DR GeneID; 2539113; -.
DR KEGG; spo:SPCC1919.11; -.
DR PomBase; SPCC1919.11; mug137.
DR VEuPathDB; FungiDB:SPCC1919.11; -.
DR eggNOG; KOG1118; Eukaryota.
DR HOGENOM; CLU_654094_0_0_1; -.
DR InParanoid; O94478; -.
DR OMA; QYLSETM; -.
DR PhylomeDB; O94478; -.
DR Reactome; R-SPO-5689901; Metalloprotease DUBs.
DR Reactome; R-SPO-9013420; RHOU GTPase cycle.
DR PRO; PR:O94478; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0032153; C:cell division site; HDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0033565; C:ESCRT-0 complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0008289; F:lipid binding; ISM:PomBase.
DR GO; GO:0006897; P:endocytosis; ISS:PomBase.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IBA:GO_Central.
DR Gene3D; 1.20.1270.60; -; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; SSF103657; 1.
DR SUPFAM; SSF50044; SSF50044; 1.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Meiosis; Nucleus; Reference proteome; SH3 domain.
FT CHAIN 1..420
FT /note="Meiotically up-regulated gene 137 protein"
FT /id="PRO_0000278628"
FT DOMAIN 10..232
FT /note="BAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00361"
FT DOMAIN 279..345
FT /note="SH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT REGION 398..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 420 AA; 48371 MW; D50CFE0FF32878F6 CRC64;
MVSRFFSWTN EKPLGDQRAH LPDSFLELEQ EIAIREEGLS KLFQATTIWI DSILKKVDGE
DKEKCLACEN LGKVMINHSK ELPQDSSYGI TLSQLGKANL KIGEHQTSLA YKARVCYLDF
LKRYLVQAKD FHSARKKLES RRQAYESLLQ KSFKEKKEDS RLEEDIRLAL YKFEESTEQV
KNRMIALKDV EADQYQQLTE LIVYELNFFK ESTGILNTIF NSQNSLTPQK KIQSSERSVE
NEFLASPMDP SLSKLFTKTT NTEKISPTPF STPKRKSKKE TVFVKAIYSF TGRNEKELDL
HTGDVIQVSE QLGPDWYMGE KVNSKAEKLG NSGMFPVNYC TRIYDLHVQK SHETRSLERA
RSIRRIVSDD PRDYCSPIKQ SPIQNLKFLD SDNSLLSSQN VEASSQPIKI RKPLPEIPNK
