MU145_SCHPO
ID MU145_SCHPO Reviewed; 309 AA.
AC P87119;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 25-MAY-2022, entry version 141.
DE RecName: Full=RING finger protein mug145;
DE AltName: Full=Meiotic expression up-regulated protein 34;
DE AltName: Full=Meiotically up-regulated gene 145 protein;
GN Name=mug145; Synonyms=meu34; ORFNames=SPAC3A12.03c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Saito T.T., Nojima H.;
RT "Meiotic expression upregulated.";
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP FUNCTION IN MEIOSIS.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes required for
RT critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
CC -!- FUNCTION: Has a role in meiosis. {ECO:0000269|PubMed:16303567}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AB237170; BAE46410.1; -; Genomic_DNA.
DR EMBL; CU329670; CAB08748.1; -; Genomic_DNA.
DR PIR; T38671; T38671.
DR RefSeq; NP_593329.1; NM_001018760.2.
DR AlphaFoldDB; P87119; -.
DR SMR; P87119; -.
DR BioGRID; 279471; 7.
DR STRING; 4896.SPAC3A12.03c.1; -.
DR PaxDb; P87119; -.
DR EnsemblFungi; SPAC3A12.03c.1; SPAC3A12.03c.1:pep; SPAC3A12.03c.
DR GeneID; 2543036; -.
DR KEGG; spo:SPAC3A12.03c; -.
DR PomBase; SPAC3A12.03c; -.
DR VEuPathDB; FungiDB:SPAC3A12.03c; -.
DR eggNOG; KOG0800; Eukaryota.
DR HOGENOM; CLU_912634_0_0_1; -.
DR InParanoid; P87119; -.
DR OMA; PLCNEDY; -.
DR PRO; PR:P87119; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; ISM:PomBase.
DR GO; GO:0008270; F:zinc ion binding; ISM:PomBase.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0070647; P:protein modification by small protein conjugation or removal; IC:PomBase.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR011016; Znf_RING-CH.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00744; RINGv; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Meiosis; Membrane; Metal-binding; Reference proteome; Transmembrane;
KW Transmembrane helix; Zinc; Zinc-finger.
FT CHAIN 1..309
FT /note="RING finger protein mug145"
FT /id="PRO_0000280180"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT ZN_FING 205..247
FT /note="RING-type; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
SQ SEQUENCE 309 AA; 35059 MW; 0CF4CDF873F7E4B5 CRC64;
MPIPKNRPMH VEEEVSSQTN TEILLFALVI ILSVIFINFF FFYLCRCCVY FYHTLENQEG
DDERPLIQHH MVNRSTGSLS PSVDRLGNVL GYDIPSRRRR SVVSKEALSC ISLEIPYIKW
LKKRKGHAKG ESTFLDNRSE NQSVIVQGQG ETPSVIITYD VRRPNLGSTS FVEMSSALSN
IYNTDASDGD SSDDSCLLED EEDFCIICYA DYAFDDILRV LPCEHVFHTQ CIDTWMTTMK
ASCPLCNEDY YKYFLQMDAA SSVTHENAAW SIPLSPGDSR THSAETDRSL LSAMSVRNSR
MPYIVSSTL
