MU154_SCHPO
ID MU154_SCHPO Reviewed; 316 AA.
AC P87236;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=Meiotically up-regulated gene 154 protein;
GN Name=mug154; ORFNames=SPCC4G3.11;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION IN MEIOSIS.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes required for
RT critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Has a role in meiosis. {ECO:0000269|PubMed:16303567}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329672; CAB09766.1; -; Genomic_DNA.
DR PIR; T41365; T41365.
DR RefSeq; NP_587827.1; NM_001022820.2.
DR AlphaFoldDB; P87236; -.
DR BioGRID; 275941; 247.
DR STRING; 4896.SPCC4G3.11.1; -.
DR iPTMnet; P87236; -.
DR MaxQB; P87236; -.
DR PaxDb; P87236; -.
DR EnsemblFungi; SPCC4G3.11.1; SPCC4G3.11.1:pep; SPCC4G3.11.
DR GeneID; 2539375; -.
DR KEGG; spo:SPCC4G3.11; -.
DR PomBase; SPCC4G3.11; mug154.
DR VEuPathDB; FungiDB:SPCC4G3.11; -.
DR eggNOG; ENOG502QV5S; Eukaryota.
DR HOGENOM; CLU_839665_0_0_1; -.
DR InParanoid; P87236; -.
DR OMA; SERWSIP; -.
DR PhylomeDB; P87236; -.
DR PRO; PR:P87236; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0061638; C:CENP-A containing chromatin; IDA:PomBase.
DR GO; GO:0034506; C:chromosome, centromeric core domain; IDA:CACAO.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; NAS:PomBase.
DR GO; GO:0070828; P:heterochromatin organization; EXP:PomBase.
DR GO; GO:0043007; P:maintenance of rDNA; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0007096; P:regulation of exit from mitosis; IBA:GO_Central.
DR InterPro; IPR018819; Nur1/Mug154.
DR PANTHER; PTHR28293; PTHR28293; 1.
DR Pfam; PF10332; DUF2418; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; Meiosis; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..316
FT /note="Meiotically up-regulated gene 154 protein"
FT /id="PRO_0000278509"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 291..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 316 AA; 37138 MW; 2C7BF3A9AFE06B58 CRC64;
MGKLIRRTSL TSKIINLPID YFIYVCEQFD SVEWDKVSDR YSIPFSLAVN FIFLLMRIYI
KSTHVPVQRN QLFVDKQSIN TSRSWFRAFL SFLSICFLFI SFLNFIFSTR FQNKLYRTLP
QDKRTTTSTP NVKPVFQHSN NDDGDEQVFE LKVWSPNQFL LNFACLFSPA HALILWFYST
SLRVTLLTFL LSFTTLHFVN KFSLLLKDQQ YLHRQVFFEY DKKFVEPRLS VVKRDVAINT
TRGPTTASIE YFTPRKPIDT FLEHRSSSHD HLTSTPRTPI ALQRRSVHHL HDSGISRDSS
SPFKRFPHLS DGSSRF
