MU174_SCHPO
ID MU174_SCHPO Reviewed; 626 AA.
AC O74434;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1999, sequence version 2.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Meiotically up-regulated gene 174 protein;
GN Name=mug174; ORFNames=SPCC1682.03c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION IN SPORULATION.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes required for
RT critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148 AND SER-162, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: Has a role in sporulation. {ECO:0000269|PubMed:16303567}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329672; CAA20669.1; -; Genomic_DNA.
DR PIR; T41060; T41060.
DR RefSeq; NP_587796.1; NM_001022789.2.
DR AlphaFoldDB; O74434; -.
DR BioGRID; 275443; 4.
DR iPTMnet; O74434; -.
DR MaxQB; O74434; -.
DR PaxDb; O74434; -.
DR PRIDE; O74434; -.
DR EnsemblFungi; SPCC1682.03c.1; SPCC1682.03c.1:pep; SPCC1682.03c.
DR PomBase; SPCC1682.03c; mug174.
DR VEuPathDB; FungiDB:SPCC1682.03c; -.
DR HOGENOM; CLU_436901_0_0_1; -.
DR OMA; RIRSCEP; -.
DR PRO; PR:O74434; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Cytoplasm; Meiosis; Phosphoprotein; Reference proteome; Sporulation.
FT CHAIN 1..626
FT /note="Meiotically up-regulated gene 174 protein"
FT /id="PRO_0000278518"
FT REGION 253..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 148
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 162
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 626 AA; 69240 MW; ECE1BC64486CB82D CRC64;
MLLKVSSCEP LVPIKQWIHT SQLDLSDSSS LVADLLYNII KFNFSGLEDK RAIFTGYESI
KRYTIGNEMF LQLAKDGFAL PVSMSYGLFL EETDTLELRA LPRSEGLHRG CEVLVLRLDS
PNELKENIRE WSSKFMNSKA SQKQQMLSPE TMQKVDLAGR ASPRYQANDS WISKKRNAPL
SSISQYANMP ENYALNTKKS KISNENDTIF KANFQQNKYE SLHAKQISAS DLSLHQEFVS
ASIVQQPELN SLLTSQSKNS TPSESDSSSS ESSSSVSDSS DLSSTSDSSS GDESSDTARQ
SSSDTISSNN VSVSVSLNTA NEFSFPQGTF KAENEAVESE VAPSSSTPPT VEEISYLHYD
EPSQYYFSSP SKLSSETTKV HRGCENTEKP SEEGKNFTTP LSDSVESENT WSNTLRSSVE
DDNTGVSDDN KKSKLNAEFD GHVNNISVRP PGSGSSATKA RNLRRKKARI LKRLMQESND
TFSANESTVV ANVPDSYLTK NDEEDSASLA SLKVAPKYVS HPVSLSSNSF HTEFPIGSLM
RFTVMDLNPV TCTPEISEKT GRVVDCSEEK VKIQLDLGDR LDLKFDVNGE VIRNRYGTTP
DEELIEGIAT YEWSSLSNVH KLELTN
