MU184_SCHPO
ID MU184_SCHPO Reviewed; 551 AA.
AC O94566;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Meiotically up-regulated gene 184 protein;
GN Name=mug184; ORFNames=SPBC1773.09c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION IN SPORULATION.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes required for
RT critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Has a role in sporulation. {ECO:0000269|PubMed:16303567}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000269|PubMed:16823372}. Note=Associates with the microtubule
CC cytoskeleton.
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DR EMBL; CU329671; CAA21914.2; -; Genomic_DNA.
DR PIR; T39674; T39674.
DR RefSeq; NP_595124.1; NM_001021031.2.
DR AlphaFoldDB; O94566; -.
DR SMR; O94566; -.
DR BioGRID; 276560; 10.
DR STRING; 4896.SPBC1773.09c.1; -.
DR iPTMnet; O94566; -.
DR MaxQB; O94566; -.
DR PaxDb; O94566; -.
DR PRIDE; O94566; -.
DR EnsemblFungi; SPBC1773.09c.1; SPBC1773.09c.1:pep; SPBC1773.09c.
DR GeneID; 2540016; -.
DR KEGG; spo:SPBC1773.09c; -.
DR PomBase; SPBC1773.09c; mug184.
DR VEuPathDB; FungiDB:SPBC1773.09c; -.
DR eggNOG; KOG0714; Eukaryota.
DR HOGENOM; CLU_494457_0_0_1; -.
DR InParanoid; O94566; -.
DR OMA; INSWINI; -.
DR PRO; PR:O94566; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0015630; C:microtubule cytoskeleton; HDA:PomBase.
DR GO; GO:0030544; F:Hsp70 protein binding; ISM:PomBase.
DR GO; GO:0006887; P:exocytosis; ISS:PomBase.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR018253; DnaJ_domain_CS.
DR InterPro; IPR036869; J_dom_sf.
DR Pfam; PF00226; DnaJ; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR PROSITE; PS00636; DNAJ_1; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 1: Evidence at protein level;
KW Chaperone; Cytoplasm; Cytoskeleton; Microtubule; Reference proteome;
KW Sporulation.
FT CHAIN 1..551
FT /note="Meiotically up-regulated gene 184 protein"
FT /id="PRO_0000278520"
FT DOMAIN 12..78
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT REGION 85..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..153
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 551 AA; 63758 MW; 772C5416E3C0B764 CRC64;
MLARPETDTS VDYYAILKLQ KNATFQQIRK QYLFLALQYH PDRNPGDEER AVKRFQRLQL
AHEVLSDATK RLIYDQLFGL STRTRSQYKP NSTSNPSKHT SAYASYNKGK NSKWSSPFAS
TTKKPQESSE KYSKKSSTRK KEHFNKKPSF PRDTEYSHIY NMKYDPRSGI GIRVKRQEPE
SLKKENNNSD YLPKSAMKQK KGGPKDSSKH PSNDGKIPES KPSVYKSRAS NLFSSNEQSI
HSSFGSKFHF DKSSNPFSFE FSPSSNAAKP SNSEECNIPK FNSSFKTSND FFTFTKTEES
SPYSFSFKLE DSNTPKFKSS SKPVKSSFVF TKPEAESSNP FSFDFGSSGP KSRSDTRNNI
RTPLWTSSVF EKPESDLPNK TAFGFMRSNT STFNQKCDDF SSASFMKEKT EFEEQLQEDN
DHSLGDLFSK INISTESPSV AMPSIPVIQP PSFPIFSSID FNVRNREYWN QLMVFQKLYS
KYCTESQHFI NSWINIKKEL HIVPVNWEIF EKVEKSWDQC EEFVAEFRQT EEKYFLFLKR
LRELINKNQM L
