MUA3_CAEEL
ID MUA3_CAEEL Reviewed; 3767 AA.
AC P34576; Q21340; Q65ZC2; Q9UA13;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2002, sequence version 2.
DT 03-AUG-2022, entry version 183.
DE RecName: Full=Transmembrane cell adhesion receptor mua-3;
DE AltName: Full=Muscle attachment abnormal protein 3;
DE Flags: Precursor;
GN Name=mua-3 {ECO:0000312|WormBase:K08E5.3a};
GN ORFNames=K08E5.3 {ECO:0000312|WormBase:K08E5.3a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
RC STRAIN=Bristol N2;
RA Lu Z., Vogel B., Hedgecock E.;
RT "mua-3 mRNA splicing pattern revealed.";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=25917920; DOI=10.1534/g3.115.018465;
RA Fotopoulos P., Kim J., Hyun M., Qamari W., Lee I., You Y.J.;
RT "DPY-17 and MUA-3 interact for connective tissue-like tissue integrity in
RT Caenorhabditis elegans: A model for Marfan Syndrome.";
RL G3 (Bethesda) 5:1371-1378(2015).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=11470827; DOI=10.1083/jcb.200007075;
RA Hong L., Elbl T., Ward J., Franzini-Armstrong C., Rybicka K.K.,
RA Gatewood B.K., Baillie D.L., Bucher E.A.;
RT "MUP-4 is a novel transmembrane protein with functions in epithelial cell
RT adhesion in Caenorhabditis elegans.";
RL J. Cell Biol. 154:403-414(2001).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=11470828; DOI=10.1083/jcb.200103035;
RA Bercher M., Wahl J., Vogel B.E., Lu C., Hedgecock E.M., Hall D.H.,
RA Plenefisch J.D.;
RT "mua-3, a gene required for mechanical tissue integrity in Caenorhabditis
RT elegans, encodes a novel transmembrane protein of epithelial attachment
RT complexes.";
RL J. Cell Biol. 154:415-426(2001).
RN [6]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1350, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC STRAIN=Bristol N2;
RX PubMed=12754521; DOI=10.1038/nbt829;
RA Kaji H., Saito H., Yamauchi Y., Shinkawa T., Taoka M., Hirabayashi J.,
RA Kasai K., Takahashi N., Isobe T.;
RT "Lectin affinity capture, isotope-coded tagging and mass spectrometry to
RT identify N-linked glycoproteins.";
RL Nat. Biotechnol. 21:667-672(2003).
RN [7]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1350; ASN-2944; ASN-3120;
RP ASN-3130; ASN-3337 AND ASN-3338, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=Bristol N2;
RX PubMed=17761667; DOI=10.1074/mcp.m600392-mcp200;
RA Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T.,
RA Taoka M., Takahashi N., Isobe T.;
RT "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis
RT elegans and suggests an atypical translocation mechanism for integral
RT membrane proteins.";
RL Mol. Cell. Proteomics 6:2100-2109(2007).
CC -!- FUNCTION: Involved in cell adhesion and required for organ positioning
CC and attachment (PubMed:25917920, PubMed:11470827, PubMed:11470828). At
CC the hypodermal surface, required for attachment of the hypdermermis to
CC the basal cuticle in postembryonic development, possibly through
CC intermediate filaments of the cytoskeleton (PubMed:11470828).
CC {ECO:0000269|PubMed:11470827, ECO:0000269|PubMed:11470828,
CC ECO:0000269|PubMed:25917920}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11470828};
CC Single-pass membrane protein {ECO:0000255}. Cell junction,
CC hemidesmosome {ECO:0000269|PubMed:11470828}. Note=Co-localizes with
CC cytoplasmic intermediate filaments at hemidesmosomes.
CC {ECO:0000269|PubMed:11470828}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a {ECO:0000312|WormBase:K08E5.3a};
CC IsoId=P34576-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:K08E5.3b};
CC IsoId=P34576-2; Sequence=VSP_016435, VSP_016436;
CC -!- TISSUE SPECIFICITY: Expressed in the hypodermis at the sites of muscle
CC contact, in striated muscles including body wall muscles, the anal
CC sphincter muscles and the junctions between the anal sphincter muscle
CC and rectal cuticle. Also expressed in non-muscle cells including the
CC excretory duct cell and pore cells. {ECO:0000269|PubMed:11470828}.
CC -!- DEVELOPMENTAL STAGE: Expressed from the two-fold stage onwards.
CC {ECO:0000269|PubMed:11470828}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in detached
CC dorsal muscles and retracted ventral muscles from the anterior and
CC posterior ends of the worm. {ECO:0000269|PubMed:11470827}.
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DR EMBL; AF139060; AAD29428.1; -; mRNA.
DR EMBL; Z30974; CAA83226.2; -; Genomic_DNA.
DR EMBL; Z30423; CAA83226.2; JOINED; Genomic_DNA.
DR EMBL; Z30974; CAH19087.1; -; Genomic_DNA.
DR EMBL; Z30423; CAH19087.1; JOINED; Genomic_DNA.
DR PIR; S42373; S42373.
DR RefSeq; NP_001022674.1; NM_001027503.3. [P34576-1]
DR RefSeq; NP_001022675.1; NM_001027504.2. [P34576-2]
DR SMR; P34576; -.
DR BioGRID; 41624; 11.
DR IntAct; P34576; 2.
DR STRING; 6239.K08E5.3a; -.
DR iPTMnet; P34576; -.
DR EPD; P34576; -.
DR PaxDb; P34576; -.
DR PeptideAtlas; P34576; -.
DR PRIDE; P34576; -.
DR EnsemblMetazoa; K08E5.3a.1; K08E5.3a.1; WBGene00003482. [P34576-1]
DR EnsemblMetazoa; K08E5.3b.1; K08E5.3b.1; WBGene00003482. [P34576-2]
DR GeneID; 176430; -.
DR KEGG; cel:CELE_K08E5.3; -.
DR UCSC; K08E5.3a; c. elegans. [P34576-1]
DR CTD; 176430; -.
DR WormBase; K08E5.3a; CE28049; WBGene00003482; mua-3. [P34576-1]
DR WormBase; K08E5.3b; CE37256; WBGene00003482; mua-3. [P34576-2]
DR eggNOG; KOG1217; Eukaryota.
DR InParanoid; P34576; -.
DR OMA; CVRNNAC; -.
DR OrthoDB; 1174178at2759; -.
DR PhylomeDB; P34576; -.
DR PRO; PR:P34576; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00003482; Expressed in embryo and 3 other tissues.
DR GO; GO:0030056; C:hemidesmosome; IDA:WormBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005882; C:intermediate filament; IDA:WormBase.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005518; F:collagen binding; ISS:WormBase.
DR GO; GO:0019215; F:intermediate filament binding; ISS:WormBase.
DR GO; GO:0007160; P:cell-matrix adhesion; IMP:WormBase.
DR CDD; cd00112; LDLa; 2.
DR Gene3D; 3.40.50.410; -; 1.
DR Gene3D; 4.10.400.10; -; 4.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF07645; EGF_CA; 26.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF00057; Ldl_recept_a; 2.
DR Pfam; PF01390; SEA; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 50.
DR SMART; SM00179; EGF_CA; 41.
DR SMART; SM00192; LDLa; 5.
DR SMART; SM00200; SEA; 2.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; SSF53300; 1.
DR SUPFAM; SSF57184; SSF57184; 1.
DR SUPFAM; SSF57424; SSF57424; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 32.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 6.
DR PROSITE; PS50026; EGF_3; 42.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS50068; LDLRA_2; 4.
DR PROSITE; PS50024; SEA; 2.
DR PROSITE; PS50234; VWFA; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell adhesion; Cell junction; Cell membrane;
KW Disulfide bond; EGF-like domain; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..3767
FT /note="Transmembrane cell adhesion receptor mua-3"
FT /id="PRO_0000007662"
FT TOPO_DOM 25..3417
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 3418..3438
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 3439..3767
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 26..63
FT /note="LDL-receptor class A 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 96..132
FT /note="LDL-receptor class A 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 133..166
FT /note="LDL-receptor class A 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 167..209
FT /note="LDL-receptor class A 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 225..268
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 375..416
FT /note="EGF-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 418..466
FT /note="EGF-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 468..517
FT /note="EGF-like 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 519..566
FT /note="EGF-like 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 614..663
FT /note="EGF-like 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 665..713
FT /note="EGF-like 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 714..760
FT /note="EGF-like 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 762..810
FT /note="EGF-like 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 816..860
FT /note="EGF-like 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 861..908
FT /note="EGF-like 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 910..961
FT /note="EGF-like 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 963..1012
FT /note="EGF-like 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1029..1070
FT /note="EGF-like 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1071..1118
FT /note="EGF-like 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1120..1168
FT /note="EGF-like 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1170..1219
FT /note="EGF-like 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1230..1406
FT /note="VWFA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT DOMAIN 1421..1466
FT /note="EGF-like 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1466..1510
FT /note="EGF-like 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1521..1562
FT /note="EGF-like 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1563..1608
FT /note="EGF-like 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1608..1656
FT /note="EGF-like 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1658..1706
FT /note="EGF-like 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1708..1755
FT /note="EGF-like 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1759..1807
FT /note="EGF-like 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1809..1860
FT /note="EGF-like 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1862..1911
FT /note="EGF-like 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1913..1961
FT /note="EGF-like 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1963..2011
FT /note="EGF-like 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2014..2062
FT /note="EGF-like 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2068..2112
FT /note="EGF-like 31"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2113..2160
FT /note="EGF-like 32"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2162..2208
FT /note="EGF-like 33"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2210..2258
FT /note="EGF-like 34"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2260..2308
FT /note="EGF-like 35"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2310..2358
FT /note="EGF-like 36"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2360..2408
FT /note="EGF-like 37"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2409..2455
FT /note="EGF-like 38"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2456..2504
FT /note="EGF-like 39"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2513..2563
FT /note="EGF-like 40"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2565..2616
FT /note="EGF-like 41"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2618..2666
FT /note="EGF-like 42"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2668..2714
FT /note="EGF-like 43"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2716..2763
FT /note="EGF-like 44"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2763..2811
FT /note="EGF-like 45"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2833..2872
FT /note="EGF-like 46"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2873..2999
FT /note="SEA 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT DOMAIN 3009..3048
FT /note="EGF-like 47"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 3049..3174
FT /note="SEA 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT DOMAIN 3176..3220
FT /note="EGF-like 48"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 3224..3272
FT /note="EGF-like 49"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 3272..3324
FT /note="EGF-like 50"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 3328..3373
FT /note="EGF-like 51; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 3373..3409
FT /note="EGF-like 52"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REGION 2492..2521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3582..3729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2501..2516
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3582..3601
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3608..3671
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3673..3688
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 201
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 207
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 383
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 515
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1350
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:12754521,
FT ECO:0000269|PubMed:17761667"
FT CARBOHYD 2944
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 3120
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 3130
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 3285
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3337
FT /note="N-linked (GlcNAc...) asparagine; atypical"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 3338
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 3394
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3414
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 27..41
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 35..54
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 62..76
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 69..89
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 97..110
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 104..123
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 131..144
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 138..157
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 165..179
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 172..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 229..243
FT /evidence="ECO:0000250"
FT DISULFID 235..252
FT /evidence="ECO:0000250"
FT DISULFID 254..267
FT /evidence="ECO:0000250"
FT DISULFID 381..392
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 386..402
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 404..415
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 422..435
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 429..444
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 446..465
FT /evidence="ECO:0000250"
FT DISULFID 472..486
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 480..495
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 497..516
FT /evidence="ECO:0000250"
FT DISULFID 523..536
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 530..545
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 547..565
FT /evidence="ECO:0000250"
FT DISULFID 618..632
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 626..642
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 644..662
FT /evidence="ECO:0000250"
FT DISULFID 669..682
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 676..691
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 693..712
FT /evidence="ECO:0000250"
FT DISULFID 718..729
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 723..738
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 740..759
FT /evidence="ECO:0000250"
FT DISULFID 766..779
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 773..788
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 790..809
FT /evidence="ECO:0000250"
FT DISULFID 820..836
FT /evidence="ECO:0000250"
FT DISULFID 828..845
FT /evidence="ECO:0000250"
FT DISULFID 847..859
FT /evidence="ECO:0000250"
FT DISULFID 865..879
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 873..888
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 890..907
FT /evidence="ECO:0000250"
FT DISULFID 914..930
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 924..939
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 941..960
FT /evidence="ECO:0000250"
FT DISULFID 967..981
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 975..990
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 992..1011
FT /evidence="ECO:0000250"
FT DISULFID 1033..1046
FT /evidence="ECO:0000250"
FT DISULFID 1040..1055
FT /evidence="ECO:0000250"
FT DISULFID 1057..1069
FT /evidence="ECO:0000250"
FT DISULFID 1075..1087
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1081..1096
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1098..1117
FT /evidence="ECO:0000250"
FT DISULFID 1124..1137
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1131..1146
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1148..1167
FT /evidence="ECO:0000250"
FT DISULFID 1174..1188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1182..1197
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1199..1218
FT /evidence="ECO:0000250"
FT DISULFID 1425..1441
FT /evidence="ECO:0000250"
FT DISULFID 1433..1450
FT /evidence="ECO:0000250"
FT DISULFID 1452..1465
FT /evidence="ECO:0000250"
FT DISULFID 1470..1484
FT /evidence="ECO:0000250"
FT DISULFID 1478..1494
FT /evidence="ECO:0000250"
FT DISULFID 1496..1509
FT /evidence="ECO:0000250"
FT DISULFID 1525..1538
FT /evidence="ECO:0000250"
FT DISULFID 1532..1547
FT /evidence="ECO:0000250"
FT DISULFID 1549..1561
FT /evidence="ECO:0000250"
FT DISULFID 1567..1583
FT /evidence="ECO:0000250"
FT DISULFID 1575..1592
FT /evidence="ECO:0000250"
FT DISULFID 1594..1607
FT /evidence="ECO:0000250"
FT DISULFID 1612..1625
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1619..1634
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1636..1655
FT /evidence="ECO:0000250"
FT DISULFID 1662..1675
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1669..1684
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1686..1705
FT /evidence="ECO:0000250"
FT DISULFID 1712..1726
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1720..1735
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1737..1754
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1763..1776
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1770..1786
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1788..1806
FT /evidence="ECO:0000250"
FT DISULFID 1813..1829
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1821..1838
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1840..1859
FT /evidence="ECO:0000250"
FT DISULFID 1866..1880
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1873..1889
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1891..1910
FT /evidence="ECO:0000250"
FT DISULFID 1917..1930
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1924..1939
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1941..1960
FT /evidence="ECO:0000250"
FT DISULFID 1967..1980
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1974..1989
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1991..2010
FT /evidence="ECO:0000250"
FT DISULFID 2018..2031
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2025..2040
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2042..2061
FT /evidence="ECO:0000250"
FT DISULFID 2072..2088
FT /evidence="ECO:0000250"
FT DISULFID 2080..2097
FT /evidence="ECO:0000250"
FT DISULFID 2099..2111
FT /evidence="ECO:0000250"
FT DISULFID 2117..2131
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2125..2140
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2142..2159
FT /evidence="ECO:0000250"
FT DISULFID 2166..2180
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2174..2189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2191..2207
FT /evidence="ECO:0000250"
FT DISULFID 2214..2228
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2222..2237
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2239..2257
FT /evidence="ECO:0000250"
FT DISULFID 2264..2278
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2272..2287
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2289..2307
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2314..2327
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2321..2336
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2338..2357
FT /evidence="ECO:0000250"
FT DISULFID 2364..2377
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2371..2386
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2388..2407
FT /evidence="ECO:0000250"
FT DISULFID 2413..2425
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2419..2435
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2437..2454
FT /evidence="ECO:0000250"
FT DISULFID 2460..2474
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2468..2483
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2485..2503
FT /evidence="ECO:0000250"
FT DISULFID 2517..2531
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2525..2541
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2543..2562
FT /evidence="ECO:0000250"
FT DISULFID 2569..2583
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2577..2594
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2596..2615
FT /evidence="ECO:0000250"
FT DISULFID 2622..2636
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2630..2645
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2647..2665
FT /evidence="ECO:0000250"
FT DISULFID 2672..2686
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2680..2695
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2697..2713
FT /evidence="ECO:0000250"
FT DISULFID 2720..2734
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2728..2743
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2745..2762
FT /evidence="ECO:0000250"
FT DISULFID 2767..2781
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2775..2790
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2792..2810
FT /evidence="ECO:0000250"
FT DISULFID 2837..2850
FT /evidence="ECO:0000250"
FT DISULFID 2842..2856
FT /evidence="ECO:0000250"
FT DISULFID 2858..2871
FT /evidence="ECO:0000250"
FT DISULFID 3013..3026
FT /evidence="ECO:0000250"
FT DISULFID 3018..3032
FT /evidence="ECO:0000250"
FT DISULFID 3034..3047
FT /evidence="ECO:0000250"
FT DISULFID 3180..3191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 3185..3201
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 3203..3219
FT /evidence="ECO:0000250"
FT DISULFID 3228..3242
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 3236..3251
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 3253..3271
FT /evidence="ECO:0000250"
FT DISULFID 3276..3288
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 3282..3297
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 3299..3323
FT /evidence="ECO:0000250"
FT DISULFID 3332..3345
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 3339..3354
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 3356..3372
FT /evidence="ECO:0000250"
FT DISULFID 3377..3386
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 3380..3397
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 3399..3408
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT VAR_SEQ 1..584
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_016435"
FT VAR_SEQ 585..614
FT /note="EKNGETVCKCLLGYKNVGTKTHLNCQMEKR -> MGRLSLGILLLAAVTSIA
FT SDNSCGGRSRLG (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_016436"
SQ SEQUENCE 3767 AA; 417291 MW; 8DA3AE5EA50AEB8E CRC64;
MQAGISIFFL FLHIPIFFVN CSNSTSCVAR EEFQCKMDDS CISMKKWQDG VDDCYDGSDE
VCLPWQFDCQ FGSPRCISKN KLHDKKIDCY SGFDEGCPAH YFVCRDRSAC IEPSKYLNGV
ADCKDKSDEP CAQNQFQCSD GTKCIPKAQF QDGKEDCDDG SDEECTTSQF ACQCGTIKCV
SDTFIMDGNW DCEDGSDEFI NKTLTANCTR NNKVNIATNS LSLGKLKFCS GKNPCKPELG
QVCVIIGGTW RCVCKLGTFR PLGSDKCIPI ELLTRYRNAP SSKCSNSHEE QFGLLQGFQK
SLSSRKELER WSNIRRAPPR TLSGTTPSGS DGFLKSGAEQ VPFMFQEDKN YVSVIPDEII
DSYGTIMTPP EFHFNRDDIR CGNKTCGLHE SCQKNSESKY ECICREGFTI FEGTCRELID
ECAQGKHDCH PEARCVDALI GYECLCREGY LDTSIDPKAR PGRKCRKLIN ECTNALMNDC
SQNARCLDKP IGYTCRCQDD YVDVSREGAR KPGRNCTQAI NECASNLHNC DTHAICQDQP
VGYSCRCPFG FIDSSPTALE PGRKCVQANN EAATTSTTTS QCIKEKNGET VCKCLLGYKN
VGTKTHLNCQ MEKRANPCQD YSLHDCDPVA ECFSEQPGYF QCQCPKGFTD SSADKRFPGR
KCVRAVDECA LGRHTCDPHA DCIDTHQGYT CKCRSGWSDT SLDPLRSPGR SCKKADMCSN
IDCAAEAECR ETPIGPMCQC VSGYVDVSRQ HGRPAGRVCR AVVNECAEGR HDCSSHATCI
DTADGFTCRC KDSYRDESSD TLKHPGKNCV RTVQPDPPEC DVSDPMSCDP AKREVCIFVE
NTYKCRCANG YSRLPDGRCV VINECAEPRL NTCGKNAECI DLAEGYTCQC RSGYADISPV
SQPGRICRAR VNECSNKEKY NVDCSENAIC ADTEHSYSCR CRPGFADVSA AFNKLPGRRC
IEAVNECASP SLNDCSKNAF CEDAKEGYIC TCRPGYVDNS PNAARHPGRI CTKPVEKIKT
DLKDTSFSTD DGCDPKNPKC GANEACVQRH GQHNCECVET AFRYTDGSCR VYSACSKRNT
CDKNAICLNR FDSYTCQCRP GYIDLSADLT NAPGRICKEL INECASSDNE CSPYARCIDA
TNGYACQCLD GFIDVSSRYN KPPGRQCTNS NNECSEKSLN TCDENADCVD TPDGYTCQCY
GGFVDVSSNA NLPPGRVCTV QTTCPKQKTD LVFLIDGSGS IGSYVFKNEV LRFVREFVEL
FEIGRSKTRV GLIQYSDQIR HEFDLDQYGD RDSLLKGISE TQYLTGLTRT GAAIQHMVQE
GFSERRGARP QQSDIARVAI ILTDGRSQDN VTGPADSARK LSINTFAIGV TDHVLASELE
SIAGSPNRWF YVDKFKDLDT RLRSMIQKAA CPSPTKQETP SEDVCNPRTQ TGCDRSLNEH
CAVENGRPRC VCPEGFTRHP FTRVCGGDLC NPQLITSCIF PEECQITPYK NFRCSCPEGY
NRDYRSGFCV SVKEVQISPQ HDANCHNGGV RCSENERCTN DGSDWFCECL PGFERIRNGQ
CAYPGSCNPN DPMSCDVRKR QQCLPRGNIY TCQCGRNEKR HPITDICLKN ECLTGEHDCD
RSARCIDTDE SYICACQSGF IDHSPNPSER PGRVCVALQN ECLDGSNRCS PNALCTDTEE
GYVCRCKSGF VDYSPNPQTF PGMVCKELVN ECTNPRLNQC DRNAHCIDTI EGYSCICKPG
FVDMDEFGNP GRRCEQIKTN DKCSPGKNDC DRNARCIQIG DDDYSCACPP GFKDKSPSSS
RPGRLCIPVI PECDNPTLND CDSPDRAVCT DTDDGYMCRC RQGFLDISPS ISVKPGRLCK
PLQNECALGI DDCARDGGIC EDNPDSFTCR CAMNYLDVSF DRVTRPGRKC KRLINECQTG
QNDCSEEATC TDTEDSYICA CPQSHIDLSP DTVNRPGRRC LMRINECTSN RHDCSPNADC
IDTPESYKCR CRDDFVDESP DSSRRPGRIC RPALVDECRT GKHDCHVNAI CQDLPQGYTC
QCSADFVDVS PHRASHPGRL CQPRPTPPPP ECRLDGGNQC KVHLNEVCRL MGGEPKCSCP
VNYQRDSSGS CSIINECLFT QLNDCHTAAD CIDQVQGYTC QCRDGFKDIG DRRRPGRMCK
PMVNECQYPH LNDCHQNAAC IDLEEGYECK CNQGFMDHSH GRPGRICKQL TNECLRPSLN
SCDRNARCID KEEGYECECR DGFIDVSPSP TLKGRACREL VNECANSRLN DCDKNARCKD
TMDSYECDCP VNSKDISPSP SFPGRVCLMF INECESGVHD CDPSATCRDN EQSFTCECPS
GFVDRSPNKH ARPGRVCVKL VDECREGRHT CSSHADCRDL EEGYTCECRD GYVDRSPNLA
SQPGRVCSAP EVCPPNHDCS SAAVCEPLGG MKYQCVCIQG YVDQSPGSQK GRVCVRNNAC
HDPRLNTCSR NAICYDEPRG YRCECKRGFM DRSPDSSQRG RVCEPPPPPS PPPRHPCQDP
ERNDCHPAGT CRATGAQSYT CECLSGYADR SPDPRNKPGR LCVLTEPVCL DPEQNDCHAA
AICSEVNGPE KYTCKCRDGY TDESPDPLRR PGRICKGLIN ECLDRSLNDC HSLAVCKDLP
NGYTCQCPIN AKDQSPDPRK PGRICSLSVN ECANPSLNSC SAFADCFDEE NGYRCRCRNG
YHDDDPAHPG HRCSFMINEC DSSNLNDCDR NANCIDTAGG YDCACKAPYR DEGPPQSPGR
ICRLNECLNP NRNTCDRNAD CRDLDYGYTC TCRHGFYDQS PNPQEPGRIC IEFQQEEHIE
RVKVTTVQSE PRREFPCGRD DCIKARGEVC ISGEYCGCKP GEGRSASTGK CQEVQETPFE
LRVVTRDQRP LMYSTEFGSQ KSPSYVEIVE LFEKNMARTF GGTSLAPRYV NTKVDYITHP
KTKNSSWDQG LLFKYEVQTT KSQSQPIDEC ELWKQMQASL DRTNGAIGGG SLRVASDTDL
LNPCKQQEEW GNCGGMSCKE HLKEVCIAGH ICGCPDGMKR RDANSECRVV ESWNVPLWVV
RDKEKPIVFS ESFDNPQTPV YKDYSKRLEK GIEGCYPHTE LKNAFVTAEV NDIVNPVLMN
ASYDTGLLFN TTVHFRKGMV HVPSDAYYQL IKYVTKENNN EVGDSELYLN PTQPDPFNPC
FKNDCDPHGK CIEISKYAYK CECGVGYRDI NPQSPGKKCL PVHGFNECER KEDNECSENA
RCIDLEHLYK CECLPSYYDT SPVGSVPGSL CVLDYCSDVN FCPTNTTCKN MEQQAECKCD
AGFMDIRKSE KRTALMLGDD TLCMHVRDVD ECALGLNNCS GVAHCIDRAV GYTCKCPDGY
IDGNPDEPGR VCGALLCDLC NAHGDCVHNT ATNNITCVCT DGWTGPQCQV APSNASLVLL
ILLALLFLLL TLCCLLYFCT KCHCFKGRRF AGAGANGFGY RRGGAWPWST LEGSASSESG
AEFSAMSAAG NDYYPDIGIP RAKLKSGMMA SGNTAEVRNM EVARLDQYLD ENAVRIPRAH
LVDAHGDTSF DSLSEASSEY TIKEEIERKV ITDVTTKEIK TTTTTDEQGN TIVTTTEAVH
PRDTTIVHGG GYTQNESSSS SFSGGERAYQ SQSQQQQSMS QGMSQSMSQH ATSAGYSSSG
MESSAHNSGY ASIRHTGERE RGGSEEEFSI GRARGMAAAS SGYQHSSSEN REVEEYCSEE
EDVEHSVGDK RTIVTKNHSY EPFVNGESER FKTEVVTSQT STHVTKK
