MUB4_ARATH
ID MUB4_ARATH Reviewed; 120 AA.
AC Q9LSD8;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Membrane-anchored ubiquitin-fold protein 4;
DE Short=AtMUB4;
DE Short=Membrane-anchored ub-fold protein 4;
DE Flags: Precursor;
GN Name=MUB4; OrderedLocusNames=At3g26980; ORFNames=MOJ10.7;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP IDENTIFICATION, NOMENCLATURE, ISOPRENYLATION AT CYS-117, METHYLATION AT
RP CYS-117, MUTAGENESIS OF CYS-117, TISSUE SPECIFICITY, INDUCTION, AND
RP SUBCELLULAR LOCATION.
RX PubMed=16831869; DOI=10.1074/jbc.m602283200;
RA Downes B.P., Saracco S.A., Lee S.S., Crowell D.N., Vierstra R.D.;
RT "MUBS: a family of ubiquitin-fold proteins that are plasma membrane-
RT anchored by prenylation.";
RL J. Biol. Chem. 281:27145-27157(2006).
CC -!- FUNCTION: May serve as docking site to facilitate the association of
CC other proteins to the plasma membrane.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16831869};
CC Lipid-anchor {ECO:0000269|PubMed:16831869}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:16831869}.
CC -!- INDUCTION: Induced by pathogens, cycloheximide and ozone treatment.
CC {ECO:0000269|PubMed:16831869}.
CC -!- MISCELLANEOUS: Heat stable and remains soluble at temperatures
CC exceeding 90 degrees Celsius.
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DR EMBL; AB026649; BAB01079.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77251.1; -; Genomic_DNA.
DR EMBL; AY045950; AAK76624.1; -; mRNA.
DR EMBL; AY079339; AAL85070.1; -; mRNA.
DR RefSeq; NP_189334.2; NM_113612.4.
DR AlphaFoldDB; Q9LSD8; -.
DR SMR; Q9LSD8; -.
DR BioGRID; 7645; 7.
DR STRING; 3702.AT3G26980.1; -.
DR PaxDb; Q9LSD8; -.
DR PRIDE; Q9LSD8; -.
DR ProteomicsDB; 238490; -.
DR DNASU; 822315; -.
DR EnsemblPlants; AT3G26980.1; AT3G26980.1; AT3G26980.
DR GeneID; 822315; -.
DR Gramene; AT3G26980.1; AT3G26980.1; AT3G26980.
DR KEGG; ath:AT3G26980; -.
DR Araport; AT3G26980; -.
DR TAIR; locus:2091975; AT3G26980.
DR eggNOG; ENOG502RZE2; Eukaryota.
DR HOGENOM; CLU_136465_1_0_1; -.
DR OMA; HICACSI; -.
DR OrthoDB; 1555986at2759; -.
DR PhylomeDB; Q9LSD8; -.
DR PRO; PR:Q9LSD8; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LSD8; baseline and differential.
DR Genevisible; Q9LSD8; AT.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR017000; MUB.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR040015; UBL3-like.
DR InterPro; IPR039540; UBL3-like_ubiquitin_dom.
DR PANTHER; PTHR13169; PTHR13169; 1.
DR Pfam; PF13881; Rad60-SLD_2; 1.
DR PIRSF; PIRSF032572; MUB; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Lipoprotein; Membrane; Methylation; Palmitate; Prenylation;
KW Reference proteome.
FT CHAIN 1..117
FT /note="Membrane-anchored ubiquitin-fold protein 4"
FT /id="PRO_0000248167"
FT PROPEP 118..120
FT /note="Removed in mature form"
FT /id="PRO_0000248168"
FT DOMAIN 7..73
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT MOD_RES 117
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000269|PubMed:16831869"
FT LIPID 115
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT LIPID 117
FT /note="S-farnesyl cysteine"
FT /evidence="ECO:0000269|PubMed:16831869"
FT MUTAGEN 117
FT /note="C->S: Loss of prenylation and membrane
FT localization."
FT /evidence="ECO:0000269|PubMed:16831869"
SQ SEQUENCE 120 AA; 13452 MW; 62704CA8ED39B07F CRC64;
MPEEDLVELK FRLYDGSDVG PFQYSPTATV SMLKERIVSE WPKDKKIVPK SASDIKLINA
GKILENGKTV AQCKAPFDDL PKSVITMHVV VQLSPTKARP EKKIEKEEAP QRSFCSCTIM
