MUC12_HUMAN
ID MUC12_HUMAN Reviewed; 5478 AA.
AC Q9UKN1; A6ND38; F5GWV9; Q9UKN0;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Mucin-12;
DE Short=MUC-12;
DE AltName: Full=Mucin-11;
DE Short=MUC-11;
DE Flags: Precursor;
GN Name=MUC12; Synonyms=MUC11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 3283-4239 AND 4894-5478, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Colon mucosa;
RX PubMed=10463611;
RA Williams S.J., McGuckin M.A., Gotley D.C., Eyre H.J., Sutherland G.R.,
RA Antalis T.M.;
RT "Two novel mucin genes down-regulated in colorectal cancer identified by
RT differential display.";
RL Cancer Res. 59:4083-4089(1999).
RN [3]
RP CLEAVAGE, AND MOTIF.
RX PubMed=11341784; DOI=10.1006/bbrc.2001.4775;
RA Parry S., Silverman H.S., McDermott K., Willis A., Hollingsworth M.A.,
RA Harris A.;
RT "Identification of MUC1 proteolytic cleavage sites in vivo.";
RL Biochem. Biophys. Res. Commun. 283:715-720(2001).
RN [4]
RP INDUCTION.
RX PubMed=15953034; DOI=10.1111/j.1462-5822.2005.00532.x;
RA Lievin-Le Moal V., Servin A.L., Coconnier-Polter M.-H.;
RT "The increase in mucin exocytosis and the upregulation of MUC genes
RT encoding for membrane-bound mucins induced by the thiol-activated exotoxin
RT listeriolysin O is a host cell defence response that inhibits the cell-
RT entry of Listeria monocytogenes.";
RL Cell. Microbiol. 7:1035-1048(2005).
RN [5]
RP CLEAVAGE, MOTIF, AND DOMAIN SEA.
RX PubMed=15943821; DOI=10.1111/j.1742-4658.2005.04711.x;
RA Palmai-Pallag T., Khodabukus N., Kinarsky L., Leir S.-H., Sherman S.,
RA Hollingsworth M.A., Harris A.;
RT "The role of the SEA (sea urchin sperm protein, enterokinase and agrin)
RT module in cleavage of membrane-tethered mucins.";
RL FEBS J. 272:2901-2911(2005).
RN [6]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=17058067; DOI=10.1007/s00109-006-0100-2;
RA Moehle C., Ackermann N., Langmann T., Aslanidis C., Kel A.,
RA Kel-Margoulis O., Schmitz-Madry A., Zahn A., Stremmel W., Schmitz G.;
RT "Aberrant intestinal expression and allelic variants of mucin genes
RT associated with inflammatory bowel disease.";
RL J. Mol. Med. 84:1055-1066(2006).
CC -!- FUNCTION: Involved in epithelial cell protection, adhesion modulation,
CC and signaling. May be involved in epithelial cell growth regulation.
CC Stimulated by both cytokine TNF-alpha and TGF-beta in intestinal
CC epithelium. {ECO:0000269|PubMed:17058067}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9UKN1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9UKN1-2; Sequence=VSP_056721;
CC -!- TISSUE SPECIFICITY: Ubiquitous, with higher expression in colon. Down-
CC regulated in colorectal cancer as well as in the colon of patients with
CC ulcerative colitis (UC) and Crohn's disease (CD).
CC {ECO:0000269|PubMed:10463611, ECO:0000269|PubMed:17058067}.
CC -!- INDUCTION: By listeriolysin O. {ECO:0000269|PubMed:15953034}.
CC -!- DOMAIN: The proteolytic cleavage occurs within the SEA domain. This
CC domain is not interchangeable, suggesting that it is insufficient to
CC mediate efficient cleavage. {ECO:0000269|PubMed:15943821}.
CC -!- MISCELLANEOUS: Infection by L.monocytogenes induces increases in mucin
CC secretion and MUC4 and MUC12 transcription. This may constitute a host
CC cell defense response that inhibits the entry of listeria monocytogenes
CC in the cell.
CC -!- WEB RESOURCE: Name=Mucin database;
CC URL="http://www.medkem.gu.se/mucinbiology/databases/";
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DR EMBL; AC105446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF147790; AAD55678.1; -; mRNA.
DR EMBL; AF147791; AAD55679.1; -; mRNA.
DR CCDS; CCDS55139.1; -. [Q9UKN1-2]
DR RefSeq; NP_001157934.1; NM_001164462.1. [Q9UKN1-2]
DR SMR; Q9UKN1; -.
DR BioGRID; 115382; 5.
DR IntAct; Q9UKN1; 4.
DR STRING; 9606.ENSP00000441929; -.
DR GlyGen; Q9UKN1; 16 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; Q9UKN1; -.
DR PhosphoSitePlus; Q9UKN1; -.
DR BioMuta; MUC12; -.
DR DMDM; 187609692; -.
DR jPOST; Q9UKN1; -.
DR MassIVE; Q9UKN1; -.
DR PaxDb; Q9UKN1; -.
DR PeptideAtlas; Q9UKN1; -.
DR PRIDE; Q9UKN1; -.
DR ProteomicsDB; 24236; -.
DR ProteomicsDB; 84823; -. [Q9UKN1-1]
DR Antibodypedia; 9093; 78 antibodies from 19 providers.
DR DNASU; 10071; -.
DR Ensembl; ENST00000379442.7; ENSP00000368755.3; ENSG00000205277.10. [Q9UKN1-1]
DR Ensembl; ENST00000536621.6; ENSP00000441929.1; ENSG00000205277.10. [Q9UKN1-2]
DR GeneID; 10071; -.
DR KEGG; hsa:10071; -.
DR MANE-Select; ENST00000536621.6; ENSP00000441929.1; NM_001164462.2; NP_001157934.1. [Q9UKN1-2]
DR UCSC; uc003uxo.4; human. [Q9UKN1-1]
DR CTD; 10071; -.
DR DisGeNET; 10071; -.
DR GeneCards; MUC12; -.
DR HGNC; HGNC:7510; MUC12.
DR HPA; ENSG00000205277; Tissue enriched (intestine).
DR MIM; 604609; gene.
DR neXtProt; NX_Q9UKN1; -.
DR OpenTargets; ENSG00000205277; -.
DR VEuPathDB; HostDB:ENSG00000205277; -.
DR eggNOG; ENOG502S5I0; Eukaryota.
DR GeneTree; ENSGT00940000165469; -.
DR HOGENOM; CLU_223165_0_0_1; -.
DR InParanoid; Q9UKN1; -.
DR OMA; TGHLYFD; -.
DR OrthoDB; 44585at2759; -.
DR PhylomeDB; Q9UKN1; -.
DR TreeFam; TF344108; -.
DR PathwayCommons; Q9UKN1; -.
DR Reactome; R-HSA-5083625; Defective GALNT3 causes HFTC.
DR Reactome; R-HSA-5083632; Defective C1GALT1C1 causes TNPS.
DR Reactome; R-HSA-5083636; Defective GALNT12 causes CRCS1.
DR Reactome; R-HSA-5621480; Dectin-2 family.
DR Reactome; R-HSA-913709; O-linked glycosylation of mucins.
DR Reactome; R-HSA-977068; Termination of O-glycan biosynthesis.
DR SignaLink; Q9UKN1; -.
DR SIGNOR; Q9UKN1; -.
DR BioGRID-ORCS; 10071; 11 hits in 1066 CRISPR screens.
DR ChiTaRS; MUC12; human.
DR GenomeRNAi; 10071; -.
DR Pharos; Q9UKN1; Tbio.
DR PRO; PR:Q9UKN1; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q9UKN1; protein.
DR Bgee; ENSG00000205277; Expressed in mucosa of sigmoid colon and 99 other tissues.
DR ExpressionAtlas; Q9UKN1; baseline and differential.
DR Genevisible; Q9UKN1; HS.
DR GO; GO:0005796; C:Golgi lumen; TAS:Reactome.
DR GO; GO:0005887; C:integral component of plasma membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0001558; P:regulation of cell growth; NAS:UniProtKB.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR Pfam; PF01390; SEA; 1.
DR SUPFAM; SSF82671; SSF82671; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50024; SEA; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Disulfide bond; EGF-like domain; Glycoprotein;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..5478
FT /note="Mucin-12"
FT /id="PRO_0000331620"
FT TOPO_DOM 17..5380
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 5381..5401
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 5402..5478
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 222..240
FT /note="1"
FT REPEAT 471..489
FT /note="2"
FT REPEAT 499..517
FT /note="3"
FT REPEAT 662..680
FT /note="4"
FT REPEAT 827..845
FT /note="5"
FT REPEAT 1159..1177
FT /note="6"
FT REPEAT 1466..1484
FT /note="7"
FT REPEAT 1633..1651
FT /note="8"
FT REPEAT 1717..1735
FT /note="9"
FT REPEAT 1882..1900
FT /note="10"
FT REPEAT 1910..1928
FT /note="11"
FT REPEAT 2075..2093
FT /note="12"
FT REPEAT 2242..2260
FT /note="13"
FT REPEAT 2549..2567
FT /note="14"
FT REPEAT 2716..2734
FT /note="15"
FT REPEAT 3023..3041
FT /note="16"
FT REPEAT 3190..3208
FT /note="17"
FT REPEAT 3274..3292
FT /note="18"
FT REPEAT 3439..3457
FT /note="19"
FT REPEAT 3467..3485
FT /note="20"
FT REPEAT 3632..3650
FT /note="21"
FT REPEAT 3799..3817
FT /note="22"
FT REPEAT 4106..4124
FT /note="23"
FT REPEAT 4273..4291
FT /note="24"
FT REPEAT 4522..4540
FT /note="25"
FT REPEAT 4550..4568
FT /note="26"
FT REPEAT 4715..4733
FT /note="27"
FT REPEAT 4743..4761
FT /note="28"
FT DOMAIN 5116..5154
FT /note="EGF-like"
FT DOMAIN 5168..5275
FT /note="SEA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT REGION 212..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..4761
FT /note="28 X 19 AA approximate tandem repeats of E-E-S-X-X-
FT X-H-X-X-P-X-X-T-X-T-X-X-X-P"
FT REGION 749..4847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4887..5034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5048..5071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5093..5112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 5226..5233
FT /note="Cleavage motif"
FT /evidence="ECO:0000250"
FT COMPBIAS 749..3967
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3974..4847
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 5229..5230
FT /note="Cleavage"
FT /evidence="ECO:0000250"
FT CARBOHYD 154
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 170
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 176
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 382
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 738
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1793
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3350
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4433
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4571
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5169
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5182
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5197
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5228
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5264
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 5144..5153
FT /evidence="ECO:0000250"
FT VAR_SEQ 23..165
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_056721"
FT VARIANT 4775
FT /note="T -> R (in dbSNP:rs11766125)"
FT /id="VAR_042906"
FT CONFLICT 3283..3286
FT /note="PGST -> RNRP (in Ref. 2; AAD55679)"
FT /evidence="ECO:0000305"
FT CONFLICT 3556
FT /note="S -> N (in Ref. 2; AAD55679)"
FT /evidence="ECO:0000305"
FT CONFLICT 3686
FT /note="S -> P (in Ref. 2; AAD55679)"
FT /evidence="ECO:0000305"
FT CONFLICT 3697
FT /note="S -> P (in Ref. 2; AAD55679)"
FT /evidence="ECO:0000305"
FT CONFLICT 3790
FT /note="P -> T (in Ref. 2; AAD55679)"
FT /evidence="ECO:0000305"
FT CONFLICT 3809
FT /note="G -> S (in Ref. 2; AAD55679)"
FT /evidence="ECO:0000305"
FT CONFLICT 3966
FT /note="R -> G (in Ref. 2; AAD55679)"
FT /evidence="ECO:0000305"
FT CONFLICT 4037
FT /note="K -> T (in Ref. 2; AAD55679)"
FT /evidence="ECO:0000305"
FT CONFLICT 4137
FT /note="T -> K (in Ref. 2; AAD55679)"
FT /evidence="ECO:0000305"
FT CONFLICT 4214
FT /note="T -> A (in Ref. 2; AAD55679)"
FT /evidence="ECO:0000305"
FT CONFLICT 4238..4239
FT /note="ST -> GP (in Ref. 2; AAD55679)"
FT /evidence="ECO:0000305"
FT CONFLICT 4901
FT /note="T -> R (in Ref. 2; AAD55678)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 5478 AA; 558164 MW; 6157CF28FEDDA0E5 CRC64;
MLVIWILTLA LRLCASVTTV TPEGSAVHKA ISQQGTLWTG EVLEKQTVEQ GKSTLRRQKN
HFHRSAGELR CRNALKDEGA SAGWSVMFAG ESVVVLVHLW MTGARVKNLG LVEFASPGDD
GDGRAEGFSL GLPLSEQARA AGAREKERQE TVINHSTFSG FSQITGSTVN TSIGGNTTSA
STPSSSDPFT TFSDYGVSVT FITGSTATKH FLDSSTNSGH SEESTVSHSG PGATGTTLFP
SHSATSVFVG EPKTSPITSA SMETTALPGS TTTAGLSEKS TTFYSSPRSP DRTLSPARTT
SSGVSEKSTT SHSRPGPTHT IAFPDSTTMP GVSQESTASH SIPGSTDTTL SPGTTTPSSL
GPESTTFHSS PGYTKTTRLP DNTTTSGLLE ASTPVHSSTG SPHTTLSPSS STTHEGEPTT
FQSWPSSKDT SPAPSGTTSA FVKLSTTYHS SPSSTPTTHF SASSTTLGHS EESTPVHSSP
VATATTPPPA RSATSGHVEE STAYHRSPGS TQTMHFPESS TTSGHSEESA TFHGSTTHTK
SSTPSTTAAL AHTSYHSSLG STETTHFRDS STISGRSEES KASHSSPDAM ATTVLPAGST
PSVLVGDSTP SPISSGSMET TALPGSTTKP GLSEKSTTFY SSPRSPDTTH LPASMTSSGV
SEESTTSHSR PGSTHTTAFP GSTTMPGLSQ ESTASHSSPG PTDTTLSPGS TTASSLGPEY
TTFHSRPGST ETTLLPDNTT ASGLLEASMP VHSSTRSPHT TLSPAGSTTR QGESTTFHSW
PSSKDTRPAP PTTTSAFVEP STTSHGSPSS IPTTHISARS TTSGLVEEST TYHSSPGSTQ
TMHFPESDTT SGRGEESTTS HSSTTHTISS APSTTSALVE EPTSYHSSPG STATTHFPDS
STTSGRSEES TASHSSQDAT GTIVLPARST TSVLLGESTT SPISSGSMET TALPGSTTTP
GLSERSTTFH SSPRSPATTL SPASTTSSGV SEESTTSRSR PGSTHTTAFP DSTTTPGLSR
HSTTSHSSPG STDTTLLPAS TTTSGPSQES TTSHSSSGST DTALSPGSTT ALSFGQESTT
FHSNPGSTHT TLFPDSTTSS GIVEASTRVH SSTGSPRTTL SPASSTSPGL QGESTAFQTH
PASTHTTPSP PSTATAPVEE STTYHRSPGS TPTTHFPASS TTSGHSEKST IFHSSPDASG
TTPSSAHSTT SGRGESTTSR ISPGSTEITT LPGSTTTPGL SEASTTFYSS PRSPTTTLSP
ASMTSLGVGE ESTTSRSQPG STHSTVSPAS TTTPGLSEES TTVYSSSRGS TETTVFPHST
TTSVHGEEPT TFHSRPASTH TTLFTEDSTT SGLTEESTAF PGSPASTQTG LPATLTTADL
GEESTTFPSS SGSTGTKLSP ARSTTSGLVG ESTPSRLSPS STETTTLPGS PTTPSLSEKS
TTFYTSPRSP DATLSPATTT SSGVSEESST SHSQPGSTHT TAFPDSTTTS DLSQEPTTSH
SSQGSTEATL SPGSTTASSL GQQSTTFHSS PGDTETTLLP DDTITSGLVE ASTPTHSSTG
SLHTTLTPAS STSAGLQEES TTFQSWPSSS DTTPSPPGTT AAPVEVSTTY HSRPSSTPTT
HFSASSTTLG RSEESTTVHS SPGATGTALF PTRSATSVLV GEPTTSPISS GSTETTALPG
STTTAGLSEK STTFYSSPRS PDTTLSPAST TSSGVSEEST TSHSRPGSTH TTAFPGSTTM
PGVSQESTAS HSSPGSTDTT LSPGSTTASS LGPESTTFHS SPGSTETTLL PDNTTASGLL
EASTPVHSST GSPHTTLSPA GSTTRQGEST TFQSWPSSKD TMPAPPTTTS AFVELSTTSH
GSPSSTPTTH FSASSTTLGR SEESTTVHSS PVATATTPSP ARSTTSGLVE ESTAYHSSPG
STQTMHFPES STASGRSEES RTSHSSTTHT ISSPPSTTSA LVEEPTSYHS SPGSTATTHF
PDSSTTSGRS EESTASHSSQ DATGTIVLPA RSTTSVLLGE STTSPISSGS METTALPGST
TTPGLSEKST TFHSSPRSPA TTLSPASTTS SGVSEESTTS HSRPGSTHTT AFPDSTTTPG
LSRHSTTSHS SPGSTDTTLL PASTTTSGPS QESTTSHSSP GSTDTALSPG STTALSFGQE
STTFHSSPGS THTTLFPDST TSSGIVEAST RVHSSTGSPR TTLSPASSTS PGLQGESTAF
QTHPASTHTT PSPPSTATAP VEESTTYHRS PGSTPTTHFP ASSTTSGHSE KSTIFHSSPD
ASGTTPSSAH STTSGRGEST TSRISPGSTE ITTLPGSTTT PGLSEASTTF YSSPRSPTTT
LSPASMTSLG VGEESTTSRS QPGSTHSTVS PASTTTPGLS EESTTVYSSS PGSTETTVFP
RTPTTSVRGE EPTTFHSRPA STHTTLFTED STTSGLTEES TAFPGSPAST QTGLPATLTT
ADLGEESTTF PSSSGSTGTT LSPARSTTSG LVGESTPSRL SPSSTETTTL PGSPTTPSLS
EKSTTFYTSP RSPDATLSPA TTTSSGVSEE SSTSHSQPGS THTTAFPDST TTPGLSRHST
TSHSSPGSTD TTLLPASTTT SGPSQESTTS HSSPGSTDTA LSPGSTTALS FGQESTTFHS
SPGSTHTTLF PDSTTSSGIV EASTRVHSST GSPRTTLSPA SSTSPGLQGE STTFQTHPAS
THTTPSPPST ATAPVEESTT YHRSPGSTPT THFPASSTTS GHSEKSTIFH SSPDASGTTP
SSAHSTTSGR GESTTSRISP GSTEITTLPG STTTPGLSEA STTFYSSPRS PTTTLSPASM
TSLGVGEEST TSRSQPGSTH STVSPASTTT PGLSEESTTV YSSSPGSTET TVFPRSTTTS
VRGEEPTTFH SRPASTHTTL FTEDSTTSGL TEESTAFPGS PASTQTGLPA TLTTADLGEE
STTFPSSSGS TGTTLSPARS TTSGLVGEST PSRLSPSSTE TTTLPGSPTT PSLSEKSTTF
YTSPRSPDAT LSPATTTSSG VSEESSTSHS QPGSTHTTAF PDSTTTSGLS QEPTASHSSQ
GSTEATLSPG STTASSLGQQ STTFHSSPGD TETTLLPDDT ITSGLVEAST PTHSSTGSLH
TTLTPASSTS AGLQEESTTF QSWPSSSDTT PSPPGTTAAP VEVSTTYHSR PSSTPTTHFS
ASSTTLGRSE ESTTVHSSPG ATGTALFPTR SATSVLVGEP TTSPISSGST ETTALPGSTT
TAGLSEKSTT FYSSPRSPDT TLSPASTTSS GVSEESTTSH SRPGSTHTTA FPGSTTMPGV
SQESTASHSS PGSTDTTLSP GSTTASSLGP ESTTFHSGPG STETTLLPDN TTASGLLEAS
TPVHSSTGSP HTTLSPAGST TRQGESTTFQ SWPNSKDTTP APPTTTSAFV ELSTTSHGSP
SSTPTTHFSA SSTTLGRSEE STTVHSSPVA TATTPSPARS TTSGLVEEST TYHSSPGSTQ
TMHFPESDTT SGRGEESTTS HSSTTHTISS APSTTSALVE EPTSYHSSPG STATTHFPDS
STTSGRSEES TASHSSQDAT GTIVLPARST TSVLLGESTT SPISSGSMET TALPGSTTTP
GLSEKSTTFH SSPRSPATTL SPASTTSSGV SEESTTSHSR PGSTHTTAFP DSTTTPGLSR
HSTTSHSSPG STDTTLLPAS TTTSGSSQES TTSHSSSGST DTALSPGSTT ALSFGQESTT
FHSSPGSTHT TLFPDSTTSS GIVEASTRVH SSTGSPRTTL SPASSTSPGL QGESTAFQTH
PASTHTTPSP PSTATAPVEE STTYHRSPGS TPTTHFPASS TTSGHSEKST IFHSSPDASG
TTPSSAHSTT SGRGESTTSR ISPGSTEITT LPGSTTTPGL SEASTTFYSS PRSPTTTLSP
ASMTSLGVGE ESTTSRSQPG STHSTVSPAS TTTPGLSEES TTVYSSSPGS TETTVFPRST
TTSVRREEPT TFHSRPASTH TTLFTEDSTT SGLTEESTAF PGSPASTQTG LPATLTTADL
GEESTTFPSS SGSTGTKLSP ARSTTSGLVG ESTPSRLSPS STETTTLPGS PTTPSLSEKS
TTFYTSPRSP DATLSPATTT SSGVSEESST SHSQPGSTHT TAFPDSTTTS GLSQEPTTSH
SSQGSTEATL SPGSTTASSL GQQSTTFHSS PGDTETTLLP DDTITSGLVE ASTPTHSSTG
SLHTTLTPAS STSTGLQEES TTFQSWPSSS DTTPSPPSTT AVPVEVSTTY HSRPSSTPTT
HFSASSTTLG RSEESTTVHS SPGATGTALF PTRSATSVLV GEPTTSPISS GSTETTALPG
STTTAGLSEK STTFYSSPRS PDTTLSPAST TSSGVSEEST TSHSRPGSMH TTAFPSSTTM
PGVSQESTAS HSSPGSTDTT LSPGSTTASS LGPESTTFHS SPGSTETTLL PDNTTASGLL
EASTPVHSST GSPHTTLSPA GSTTRQGEST TFQSWPNSKD TTPAPPTTTS AFVELSTTSH
GSPSSTPTTH FSASSTTLGR SEESTTVHSS PVATATTPSP ARSTTSGLVE ESTTYHSSPG
STQTMHFPES NTTSGRGEES TTSHSSTTHT ISSAPSTTSA LVEEPTSYHS SPGSTATTHF
PDSSTTSGRS EESTASHSSQ DATGTIVLPA RSTTSVLLGE STTSPISSGS METTALPGST
TTPGLSEKST TFHSSPSSTP TTHFSASSTT LGRSEESTTV HSSPVATATT PSPARSTTSG
LVEESTAYHS SPGSTQTMHF PESSTASGRS EESRTSHSST THTISSPPST TSALVEEPTS
YHSSPGSIAT THFPESSTTS GRSEESTASH SSPDTNGITP LPAHFTTSGR IAESTTFYIS
PGSMETTLAS TATTPGLSAK STILYSSSRS PDQTLSPASM TSSSISGEPT SLYSQAESTH
TTAFPASTTT SGLSQESTTF HSKPGSTETT LSPGSITTSS FAQEFTTPHS QPGSALSTVS
PASTTVPGLS EESTTFYSSP GSTETTAFSH SNTMSIHSQQ STPFPDSPGF THTVLPATLT
TTDIGQESTA FHSSSDATGT TPLPARSTAS DLVGEPTTFY ISPSPTYTTL FPASSSTSGL
TEESTTFHTS PSFTSTIVST ESLETLAPGL CQEGQIWNGK QCVCPQGYVG YQCLSPLESF
PVETPEKLNA TLGMTVKVTY RNFTEKMNDA SSQEYQNFST LFKNRMDVVL KGDNLPQYRG
VNIRRLLNGS IVVKNDVILE ADYTLEYEEL FENLAEIVKA KIMNETRTTL LDPDSCRKAI
LCYSEEDTFV DSSVTPGFDF QEQCTQKAAE GYTQFYYVDV LDGKLACVNK CTKGTKSQMN
CNLGTCQLQR SGPRCLCPNT NTHWYWGETC EFNIAKSLVY GIVGAVMAVL LLALIILIIL
FSLSQRKRHR EQYDVPQEWR KEGTPGIFQK TAIWEDQNLR ESRFGLENAY NNFRPTLETV
DSGTELHIQR PEMVASTV
