MUC15_MOUSE
ID MUC15_MOUSE Reviewed; 331 AA.
AC Q8C6Z1; Q3UQC4; Q6XYQ9; Q7TMH6; Q8CE82;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Mucin-15;
DE Short=MUC-15;
DE Flags: Precursor;
GN Name=Muc15;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lactating mammary gland;
RA Bierie B., Cui K., Miyoshi K., Tang W., Hennighausen L.;
RT "Cloning and characterization of two mouse MUC15 splice forms.";
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland, and Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 195-331.
RC STRAIN=C57BL/6J; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- PTM: Highly glycosylated (N- and O-linked carbohydrates).
CC {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAO45176.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAO45177.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AY198336; AAO45176.1; ALT_FRAME; mRNA.
DR EMBL; AY198337; AAO45177.1; ALT_FRAME; mRNA.
DR EMBL; AK028832; BAC26143.1; -; mRNA.
DR EMBL; AK052840; BAC35171.1; -; mRNA.
DR EMBL; AK142590; BAE25118.1; -; mRNA.
DR EMBL; BC055469; AAH55469.1; -; mRNA.
DR CCDS; CCDS16513.1; -.
DR RefSeq; NP_001277715.1; NM_001290786.1.
DR RefSeq; NP_766567.1; NM_172979.3.
DR AlphaFoldDB; Q8C6Z1; -.
DR STRING; 10090.ENSMUSP00000106645; -.
DR GlyGen; Q8C6Z1; 12 sites.
DR iPTMnet; Q8C6Z1; -.
DR PhosphoSitePlus; Q8C6Z1; -.
DR PaxDb; Q8C6Z1; -.
DR PRIDE; Q8C6Z1; -.
DR ProteomicsDB; 287520; -.
DR Antibodypedia; 12684; 143 antibodies from 28 providers.
DR DNASU; 269328; -.
DR Ensembl; ENSMUST00000090332; ENSMUSP00000087805; ENSMUSG00000050808.
DR Ensembl; ENSMUST00000111016; ENSMUSP00000106645; ENSMUSG00000050808.
DR GeneID; 269328; -.
DR KEGG; mmu:269328; -.
DR UCSC; uc008lmz.2; mouse.
DR CTD; 143662; -.
DR MGI; MGI:2442110; Muc15.
DR VEuPathDB; HostDB:ENSMUSG00000050808; -.
DR eggNOG; ENOG502S7P0; Eukaryota.
DR GeneTree; ENSGT00390000001698; -.
DR HOGENOM; CLU_054055_0_0_1; -.
DR InParanoid; Q8C6Z1; -.
DR OMA; PDEWLTT; -.
DR OrthoDB; 1169762at2759; -.
DR PhylomeDB; Q8C6Z1; -.
DR TreeFam; TF338656; -.
DR Reactome; R-MMU-913709; O-linked glycosylation of mucins.
DR Reactome; R-MMU-977068; Termination of O-glycan biosynthesis.
DR BioGRID-ORCS; 269328; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q8C6Z1; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8C6Z1; protein.
DR Bgee; ENSMUSG00000050808; Expressed in epithelium of cochlear duct and 61 other tissues.
DR ExpressionAtlas; Q8C6Z1; baseline and differential.
DR Genevisible; Q8C6Z1; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR031371; Mucin-15.
DR PANTHER; PTHR45427; PTHR45427; 1.
DR Pfam; PF15672; Mucin15; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..331
FT /note="Mucin-15"
FT /id="PRO_0000019289"
FT TOPO_DOM 23..233
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..331
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 124..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 302..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..178
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 30
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 44
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 54
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 59
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 75
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 84
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 120
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 136
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 145
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 152
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 215
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 222
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 308
FT /note="M -> L (in Ref. 3; AAH55469)"
FT /evidence="ECO:0000305"
FT CONFLICT 327
FT /note="L -> F (in Ref. 3; AAH55469)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 331 AA; 36383 MW; A53CC7F6265591D0 CRC64;
MLTLAKIALI SSLFISLPFA RPQKQNPRRN VTQHTIEDVK IMRNNSIHLE RSINVTSENG
SDISNLMVTT PSPLNLSTTF RTTNSTRTWL MTSSSESSRP SSTYSVPPLV QGFVSKLPLN
SSTADANPLQ VSEHSNSTNS PSPENFTWSL DNDTMNSPED ISTTVRPFPP PPKTTPVTPF
TAEPTEWLPT NNDNFAGFTP YQEKTTLQPT LKFTNNSKLF PNTSDTPKEN KNTGIVFGAI
LGAILGASLL SLVGYLLCGQ RKTDSFSHRR LYDDRNEPVL RLDNAPEPYD VNFGNSSYYN
PAVSDSSMPE GGESLQDGIP MDAIPPLRPS I
