MUC19_HUMAN
ID MUC19_HUMAN Reviewed; 8384 AA.
AC Q7Z5P9; G3CIG0; Q8NA85;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-JUN-2016, sequence version 3.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Mucin-19;
DE Short=MUC-19;
DE Flags: Precursor;
GN Name=MUC19;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Salivary gland;
RX PubMed=21075863; DOI=10.1165/rcmb.2010-0312oc;
RA Zhu L., Lee P., Yu D., Tao S., Chen Y.;
RT "Cloning and Characterization of Human MUC19 Gene.";
RL Am. J. Respir. Cell Mol. Biol. 45:348-358(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 7684-8384 (ISOFORM 1), AND TISSUE
RP SPECIFICITY.
RX PubMed=12882755; DOI=10.1165/rcmb.2003-0103oc;
RA Chen Y., Zhao Y.H., Kalaslavadi T.B., Hamati E., Nehrke K., Le A.D.,
RA Ann D.K., Wu R.;
RT "Genome-wide search and identification of a novel gel-forming mucin
RT MUC19/Muc19 in glandular tissues.";
RL Am. J. Respir. Cell Mol. Biol. 30:155-165(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7684-8384 (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=17667140; DOI=10.1097/mlg.0b013e31806db531;
RA Kerschner J.E.;
RT "Mucin gene expression in human middle ear epithelium.";
RL Laryngoscope 117:1666-1676(2007).
RN [6]
RP FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=18184611; DOI=10.1016/j.exer.2007.11.013;
RA Yu D.F., Chen Y., Han J.M., Zhang H., Chen X.P., Zou W.J., Liang L.Y.,
RA Xu C.C., Liu Z.G.;
RT "MUC19 expression in human ocular surface and lacrimal gland and its
RT alteration in Sjogren syndrome patients.";
RL Exp. Eye Res. 86:403-411(2008).
CC -!- FUNCTION: May function in ocular mucus homeostasis.
CC {ECO:0000269|PubMed:18184611}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7Z5P9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7Z5P9-2; Sequence=VSP_034521, VSP_034522;
CC -!- TISSUE SPECIFICITY: Expressed corneal epithelial cells, conjunctival
CC goblet and epithelial cells and lacrimal gland cells (at protein
CC level). Expressed by mucous cells of the submandibular gland and
CC submucosal gland of the trachea. Expressed by middle ear epithelial
CC cells. {ECO:0000269|PubMed:12882755, ECO:0000269|PubMed:17667140,
CC ECO:0000269|PubMed:18184611}.
CC -!- INDUCTION: Down-regulated in Sjoegren syndrome patients (at protein
CC level). {ECO:0000269|PubMed:18184611}.
CC -!- CAUTION: According to the Genome Reference Consortium, the reference
CC genome GRCh38/hg38 is in conflict with the sequence shown here.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC04041.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Mucin database;
CC URL="http://www.medkem.gu.se/mucinbiology/databases/";
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DR EMBL; HM801842; AEM63682.1; -; mRNA.
DR EMBL; AC024935; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC074030; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC107023; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY236870; AAP41817.1; -; mRNA.
DR EMBL; AK093065; BAC04041.1; ALT_INIT; mRNA.
DR RefSeq; NP_775871.2; NM_173600.2. [Q7Z5P9-1]
DR SMR; Q7Z5P9; -.
DR IntAct; Q7Z5P9; 1.
DR iPTMnet; Q7Z5P9; -.
DR PhosphoSitePlus; Q7Z5P9; -.
DR BioMuta; HGNC:14362; -.
DR EPD; Q7Z5P9; -.
DR jPOST; Q7Z5P9; -.
DR MassIVE; Q7Z5P9; -.
DR PaxDb; Q7Z5P9; -.
DR PeptideAtlas; Q7Z5P9; -.
DR PRIDE; Q7Z5P9; -.
DR ProteomicsDB; 69340; -. [Q7Z5P9-1]
DR ProteomicsDB; 69341; -. [Q7Z5P9-2]
DR DNASU; 283463; -.
DR GeneID; 283463; -.
DR KEGG; hsa:283463; -.
DR CTD; 283463; -.
DR DisGeNET; 283463; -.
DR GeneCards; MUC19; -.
DR HGNC; HGNC:14362; MUC19.
DR MIM; 612170; gene.
DR neXtProt; NX_Q7Z5P9; -.
DR InParanoid; Q7Z5P9; -.
DR OrthoDB; 12226at2759; -.
DR PathwayCommons; Q7Z5P9; -.
DR Reactome; R-HSA-5083625; Defective GALNT3 causes HFTC.
DR Reactome; R-HSA-5083632; Defective C1GALT1C1 causes TNPS.
DR Reactome; R-HSA-5083636; Defective GALNT12 causes CRCS1.
DR Reactome; R-HSA-5621480; Dectin-2 family.
DR Reactome; R-HSA-913709; O-linked glycosylation of mucins.
DR Reactome; R-HSA-977068; Termination of O-glycan biosynthesis.
DR BioGRID-ORCS; 283463; 1 hit in 148 CRISPR screens.
DR ChiTaRS; MUC19; human.
DR GenomeRNAi; 283463; -.
DR Pharos; Q7Z5P9; Tdark.
DR PRO; PR:Q7Z5P9; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q7Z5P9; protein.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005796; C:Golgi lumen; TAS:Reactome.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR014853; Unchr_dom_Cys-rich.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR Pfam; PF08742; C8; 3.
DR Pfam; PF01826; TIL; 1.
DR Pfam; PF00094; VWD; 3.
DR SMART; SM00832; C8; 2.
DR SMART; SM00041; CT; 1.
DR SMART; SM00214; VWC; 3.
DR SMART; SM00215; VWC_out; 2.
DR SMART; SM00216; VWD; 3.
DR SUPFAM; SSF57567; SSF57567; 3.
DR PROSITE; PS01185; CTCK_1; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS50184; VWFC_2; 1.
DR PROSITE; PS51233; VWFD; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Disulfide bond; Reference proteome; Repeat; Secreted;
KW Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..8384
FT /note="Mucin-19"
FT /id="PRO_0000342664"
FT DOMAIN 478..649
FT /note="VWFD 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 815..995
FT /note="VWFD 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 1274..1447
FT /note="VWFD 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 8159..8225
FT /note="VWFC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 8288..8376
FT /note="CTCK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT REGION 33..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1680..1699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1732..2464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2238..6086
FT /note="Approximate repeats of G-V-T-G-T-T-G-P-S-A"
FT /evidence="ECO:0000305"
FT REGION 2484..2526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2540..2827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2850..2917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2984..3027
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3075..3368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3386..3428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3585..3628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3667..3736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4105..4147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4187..4251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4315..4390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4414..4455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4510..4583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4790..4843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4895..4930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5130..5161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5429..5452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5464..5494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5880..5918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6069..6403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6440..6918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6953..7223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7250..7749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7783..7975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8020..8133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..79
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..412
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..457
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1740..1757
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1777..1865
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1873..1939
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1955..2337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2346..2464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2484..2525
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2541..2614
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2631..2827
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2870..2913
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3585..3622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3669..3732
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4187..4240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4510..4579
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4790..4839
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6069..6125
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6132..6364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6371..6403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6440..6543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6554..6916
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6953..7180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7191..7223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7250..7331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7342..7358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7366..7520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7544..7626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7639..7672
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7686..7749
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 502..648
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 817..952
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 838..994
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 857..865
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 1276..1411
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 1298..1446
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 1307..1408
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 1323..1330
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 8288..8339
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 8306..8353
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 8315..8369
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 8319..8371
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT VAR_SEQ 8049..8066
FT /note="GNTPGSTGVTSSQEGTTV -> DSPSFPLFLICSYRGHNF (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034521"
FT VAR_SEQ 8067..8384
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034522"
FT VARIANT 717
FT /note="G -> E (in dbSNP:rs7955308)"
FT /id="VAR_056617"
FT VARIANT 783
FT /note="T -> K (in dbSNP:rs11564170)"
FT /id="VAR_056618"
FT VARIANT 790
FT /note="V -> I (in dbSNP:rs7958987)"
FT /id="VAR_056619"
FT VARIANT 791
FT /note="R -> L (in dbSNP:rs17467284)"
FT /id="VAR_056620"
FT VARIANT 803
FT /note="D -> H (in dbSNP:rs11564245)"
FT /id="VAR_056621"
FT VARIANT 843
FT /note="V -> I (in dbSNP:rs10506156)"
FT /id="VAR_056622"
FT VARIANT 869
FT /note="V -> I (in dbSNP:rs28365246)"
FT /id="VAR_056623"
FT VARIANT 883
FT /note="V -> I (in dbSNP:rs11564125)"
FT /id="VAR_056624"
FT VARIANT 1010
FT /note="L -> F (in dbSNP:rs12317988)"
FT /id="VAR_056625"
FT VARIANT 1151
FT /note="I -> T (in dbSNP:rs11176635)"
FT /id="VAR_056626"
FT VARIANT 1226
FT /note="S -> F (in dbSNP:rs4768261)"
FT /id="VAR_056627"
FT VARIANT 1278
FT /note="I -> M (in dbSNP:rs7966110)"
FT /id="VAR_056628"
FT VARIANT 1296
FT /note="G -> S (in dbSNP:rs4768264)"
FT /id="VAR_056629"
FT VARIANT 1315
FT /note="R -> H (in dbSNP:rs7312154)"
FT /id="VAR_056630"
FT VARIANT 1327
FT /note="G -> W (in dbSNP:rs12369002)"
FT /id="VAR_056631"
FT VARIANT 1367
FT /note="A -> T (in dbSNP:rs11564141)"
FT /id="VAR_056632"
FT VARIANT 1411
FT /note="C -> Y (in dbSNP:rs11564109)"
FT /id="VAR_056633"
FT VARIANT 1451
FT /note="A -> T (in dbSNP:rs11176666)"
FT /id="VAR_056634"
FT VARIANT 1493
FT /note="A -> V (in dbSNP:rs10784621)"
FT /id="VAR_056635"
FT VARIANT 1621
FT /note="N -> S (in dbSNP:rs17128169)"
FT /id="VAR_056636"
FT VARIANT 1688
FT /note="T -> A (in dbSNP:rs17128233)"
FT /id="VAR_056637"
FT VARIANT 1762
FT /note="E -> A (in dbSNP:rs2933353)"
FT /id="VAR_056638"
FT VARIANT 1770
FT /note="S -> R (in dbSNP:rs7956459)"
FT /id="VAR_056639"
FT VARIANT 2029
FT /note="A -> S (in dbSNP:rs1492333)"
FT /id="VAR_056640"
FT CONFLICT 8091
FT /note="T -> S (in Ref. 3; AAP41817)"
FT /evidence="ECO:0000305"
FT CONFLICT 8327
FT /note="Y -> H (in Ref. 3; AAP41817)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 8384 AA; 805253 MW; D4FFE16047237C93 CRC64;
MKLILWYLVV ALWCFFKDVE ALLYRQKSDG KIAASRSGGF SYGSSSSGDL DRKKPLFSLE
FGSPGETEDK SRQRQDAGSP KSEDTPAGGF FNSSSSSGDS DRTKPFFSLG LGAPGKAEDK
SGDSQDAGGS KSEDTPPGGF FYGSSSSGDS DKKKPLFSFE FGATGEDEDK SRERWDAGNS
RSEDSPADST NTRYGAGFSS SGASLDVGFG WGISDEKGLE VSKADGRETR GSGSAGGETI
VFGPDAGSSV GTGSSGLKLG AGKGDAAFGF EVSDSNSFGD TGISSKTVEG NQTSSSGGSV
SIDLGDTSFR SENQFVGGGS LNSISNLWDS GQEGFGINEI GGNGMSGSVS AEAGFKGFGS
DSSSSGDSSA RNGFENSSGI SEDSGVILGS SDQHEVELSR TGGNRKRSSD PDEAGNLSPG
SDVSDSGGNT WSSDSGSGGG GVTSSSEYST SGPLNTPEKG SHIPEATPKY SETNAIIGEI
STWSKGAYKS FNGRIFFFES SCPYTFCRHC IESGGDFNIE IKRNNDSEIE KITVLIDNND
VSIFGDTILV NGESVQIPYN NKLIHIKKYG EHNVLNSRRG ILTLMWDKNN KLSLTLHKQY
PTCGLCGNFN STPGQDINEH IANSKIPGDC PNAVGKSYEV CEDGIQHCNK IIGTYFEKCG
KVAALSNDYK MICIDEYCQT RDKTSTCDTY SELSRLCASD GPGTFESWRS DSDVVCGTQR
CPEQHIYKEC GPSNPATCSN VAPFQDSECV SGCTCPEGYL LDDIGEKGKC VLKAECPCES
SGTVYQPGEV REGPCGSQCT CQDAKWSCTE ALCPGRCKVE GSSLTTFDGV KYNFPGNCHF
LAVHNEDWSI SVELRPCPSG QTGTCLNSVT LLLNSSVPVD KYVFNSDGTV TNDKIRNQGY
YYSDKIQIFN ASSSYLQVET YFHVKLQIQI VPVMQLYVSM PPNQFTDTVG LCGSYNNKAE
DDFMSSQNIL EKTSQAFANS WEMMSCPKGN PSSCISIEKE KFAERHCGIL LDSSGPLASC
HPIVNPKPYH EECKKYTCTC ENSQDCLCTI LGNYVKACAE KETYIVGWRT GLCEHSCPSG
LVFKYNVKAC NSSCRSLSER DRSCDVEDVP VDGCTCPDAM YQNNEGNCVL KSQCDCYIND
EVMQPGKLIH IDDNKCVCRD GILLCQIPID LTLQNCSGGA EYVDCSDPKA QRRTNRTCST
RNIPVFDENL PCKRGCFCPE GMVRNSKGIC VFPNDCPCSF GGREYDEGSV TSVGCNECTC
IKGSWSCTQN ECQTICHIYG EGHVRTFDGK SYSFDGLCQY SFLEDYCGHE NGTFRILTES
VPCCEDGLTC SRKIIVAFQD QNIVLQDGKV TAVKSTESKK CELNANAYSI HTVGLYLILK
FQNGIIVIWD KNTRLSVILD PNWNGKVCGL CGNNNGDLKD DFTTRYSSVA SGALEFGNSW
KTSQECSDTV AQTFPCDSNP YCKAWAVRKC EILRDSTFRD CHNKVDPSAY HDACIEEACA
CDMEGKYLGF CTAVAMYAEA CSAVGVCVSW RKPNLCPVYC DYYNAPGECR WHYEPCGTVT
AKTCKDQLVG QKFSSLLEGC YAKCPDSAPY LDENTMKCVS LSECSCFYND VIPAGGVIED
NCGRTCYCIA GQLECSETAP TNSTFAVSTT TATTILSTGA AITLVTGGPS TAASIPAITT
SSSETTGTTL GPLTEPFTTG ITETSVPIIS TSGNAGMTGV VSPTVTGASG MAGTTGGVDA
ATTGAASENT SERAGTPRVS GETPAVGGGS TPGEAGPGAT VSGSTGVSAG SITASPGASA
TSSESSKSGT TGPSVGGKTG ATSSEATSSE GMSGVTGQSL GSTAGSDSEI TAKTSFTGSS
PPGKLTRPSP GSPGHFSGGT TEWGNVATTG AAGENTSGAL GSTEGSVEAT TSAGSGNTAG
TSGTGDTGPG NTAVSGTPVV SPGATPGAPG SSTPGEADIG NTSFGKSGTP TVSAASTTSS
PVSKHTDAAS ATAVTISGSK PGTPGTPGGA TSGGKITSGW SSSGTSTGAS NTPGATGSST
GQTDTSGPSA KVTGNYGQSS EIPGTIKSSS DVSGTMGQSD TTSGPSVAVT RTSEQSSGVT
VASEPSVGVS GTTGPLAEIS GTTRPLVSGL RTTGSSAEGS GTTGPSSRES VTTRPLAEGS
GTSGQSVTGS RATGLSATEL GTTVSFTGGL GTSRSSARET RTTGPSADGS GTTGPSVVRS
GTTRLSVGVT RATESSPGVT GTTTPSAEES RTTGPSVLVT GTTGQSGQGS GTTGKSFIES
GPSVVGSGTT GPTSAGLGTT APSTRRSSTT KPSVGRTGTT GQSGAESGTT EPSARVAGVT
GTSAEVSGRI EPSATESSTS RPLGETTGTT IPSMEGSEAT GPSVIGSETT RLSVIGSGTT
GTSSGGSGAT RSSGGGMGTT GQSTARSETT GPLFGLTGTF GQSATVTGTS SNSAGVTTPE
KSPGVAMTTG LLVEGSATTQ PRILESETTE SSAGVIVTSG QSARVTGATG PSAGETGTTE
PSTEGSVAAV LFVIGSETTR PLDIGSGTTG TLSGGSSTTR SSDGTTGTTR KSTARSETTG
LSGLTGTSGQ LAGVTGTSSK SAGVTVTSEK SAGVAVITGS FVERPVTTGP PLLESETTRP
SGGVTVTSGQ SARVTETVGA SAGVTGTTGP STEGSGATGP SVVGSGTTRP LAGESGTTES
SAGVTGTRPS SSRESATTGP SDEGSGTTGL SAGVTVTSGQ SVRKTGTTGA PAGVTETTRP
SVVKSGTTGP SVIGTRTTGT SSGGSGATRS SGGETETTGQ SAVKSGTTES FTRLTRTSGQ
SAGMTGTSAQ SAGVALTSPF VEGLVTTGSS TVGLETTRPS AVGSGKTGPP VVKAQTTGPS
AGVTVTSGQS ARMTGASGPS VGVTGTTGPA SKGLGTIRPS VVGLETTELS AEGSGTTGPP
IVGETTVPSA GVTVTSGYSD RVTGATEPLA GVTGTIKPSV AGSVTTGPSV TGVETTAKTT
SGGLSTTISS VGGTGTTGQS PERSGTTGPF TGLTGTSAQS AGVTMTSIQS AGVLVTTGLN
VDGLGTTGKA LIGSGTTGLS AEATGTIGPS TEGLEKTGPS ITGSGTTRPL VTESWTAGTS
SGGHSTTSPS VRGTETTGQS AAESVTTGPV TGYTETSGPS AGVTVTPRQS PTVTQTTGSS
AAVSGTTVQS LTVSGTTRPS SGQTEITGSS VKESGTTESS AVRSGTTGPT AGVTGTNGPS
SAGVTGITGS SPGVTGTTGS SPGVTGTTGS SARSGTSIPS VGKTGTTRTS VEESRTTRPS
AGITGTNGLS AEVTGTTGPL AGVTGTTGPS AGVTRTTGLS AGETGTTGLS PGVTRTTRSS
AGLTGKTGLS AGVTGKTGLS AEVTGTTRLS AGVTGTTGPS PGVTGTTGTP AGVTGTTELS
AGVTGKTGLS SEVTETTGLS YGVKRTIGLS AGSTGTSGQS AGVAGTTTLS AEVTGTTRPS
AGVTGTTGLS AEVTEITGIS AVVTGTTGPS AGVTETTGSS AGVAGTTRLS AGVTGITGLS
AGVTGTTGLS TEVTGTTGPS AGATGTTGLS VGVTGITGLS DVVTETTGSS ARSGTGIPSV
GETRTTSTSV EESRTTRPSA GIMGTNGLPA EVTGTTEPLA GGTGTTGILA GVTGTTGLSA
GETGKIGSSA GVTGKTGSSA RVTGKTGPSA EVTGKTGLSA GVTGTTGLSP GVTGTSGLSA
EVTGTTGPSA EATGLPGVSA GVTGTTGSLA GGTGTIGLSA GVTGTTGSSA GVTGTTGLSA
GVTGIAGLSA GVTGITGPSA GVTGTTTVSA GVTGTTGLSA EATEITGLSA GVTGTTGLSA
GVTETIRLSA GVTGTIRSSA GVTGITGLSA GVTGTTGPSA GVTGSTGLLA GVTETTGQSA
KVTGTTGQSV GVTGTTRSSG GVTGITGLSA GVTGTNGLSA VTGMTGLSAE VTGTTGLSVG
VTGIAGLSAG VTGITGPSAG ITGTTTISAG VTGTSGLSAE ATGITGLSAG VTGKTGLSAG
VTETIGLSAE ATGTIGSSPG VTGTTGSSTG VTGITGLSAG VTGTTGLSTE VTGTTGPSAG
VTRTTGLSAG VTGITGLSAI VTETTGSSAR SGTSIPSVGE TGTTRTSVEE SRTTRPSAGI
TGTNGLSAEV TGTIGPLAGG TGTTGLSAGV TGTVGSSAVV TGTTGLSAGV TGTTGPSAEE
TGATGPSAEV TETTGPSAGV TGTGRLSAEV TGTTGPSAEV TGLPGESAEV TGTIGSPAGV
TGTTQLSAVV TGITGLSAEV TGTTGLSAGV TGITGLSAEV TRTTGLSAGV TGTIGLSAGV
TGTTRPSAGV TGTTGQSAEV TGTTEPSAGL TETTGSSTGV TGATGPLAGV TGTTGISTEV
TGTTGPSARV TGTTVLSAGV TGITGLSAIV TETTGSSARS GTSTPSVGET GTTRTSVEES
RATRPSAGIT GTNGQSAEVT WITGPLAGVT GTTGISAGVT GTTGLSAGVT GTIGSSAVVT
GINGLSAGVT GTTGPSAEET GATGPSAEVT GTTGPSAEET GATGPSAEVT GTTGPSGGVT
GTNGLSAEVT GTTGPSAEVT GLPGVSAGVT GTIGSPAAVT GTIRPSAVVT GITGLSAEVT
GTTGLSAWVT GIAGLSAGVT ETIGSSAGVT GTNGLSAEAT GTTGPSAGVT GTTGLSAGVT
GTAGLSARVT ESTGLSAGVT GTTGLSAGVT GTTGPSAGIT GTNGLSAEVT GTTGPLAGVT
GTIGLSAGVT GIAGLSAGVT ESTGLSAGVT GTIRSSAVVT GINGLSAGVT GTTGPSAEET
GATGPSAEVT GTTGPSGGVT GTSGISAEVT GTTGPSAEVT GLPGVSAGVT GTIGSPAAVT
GTTRPSAVVT GISGLSAEVT GTTGLSAGVT ETIGSSAGVT GTNGLSAEAT ETTGPSAGVT
GTTGLSAGVT GTTGPSAGIA GTNGLSAGVT GTTGLSARVT ESTGLSAGVT GTIGSSAVVT
ETTRLSSGVT GTIGPSAEET GATGLSAEVT GTTGSLAEVT GTTGLSAGVT GTIGSSAVVT
GTTGLSAGIT GTNGLSAEVT GTAGPLAGVT GTTGLSAGVT GTTGLSAGVT ETTGQSAGVT
ESTGLSPGVT GTIGSSAVVT GIKGLSAGVT GTTGPSAEET GATGPSAEVT GTTGPSGGVT
GTSVLSVEVT GTTGPSAEVT GLPGVSAGLT GTIGSPAAVR GTTWPSAVVT GISGLSGEVT
GTTGLSAGVT GIGGLSAGVT GTIGSSAGVT GTNALSAEAT GTTGPSAGVT GTTGLSAGVT
GTTGLSAGVT GTIRSSAVVT ETTGLSAGVT GTTGPSAGIA GTNGLSAEVT GTTGLSAGMT
GTTGLSARVT ESTGLSAGVT GTIGSSAVVT ETTRLSAGVT GTIGPSAEET GATGLSAEVT
RTTGSLAGVT GTTGPSAVVT GKTELSAEVT GTTELSAEVT EKTGPSAEVT GKTGLSAGVM
ETTGPSAEVT GTTGSSAGVT GTTGPSAGVT GTTGPSAEAT GLPGVSAGVT GTIGSPAGVT
GTARLSAVVT GISGLSAEVT GTTGLSTGVT GIAGHSAAVT GITRPSAGVT GTTTVSAGVT
GTIGLSAEAT GITLPSAGVT ETTGLSAGVT ETIGLSAGVT GTIGSSAGVT EITGLSAGVT
GTTGPSAGVT GSTVLSAGVT ATTGQSVGVT GTTGPSAGVT GTTGLSAGVT GIAGLSAGVT
GITGPSAGVT GTTTVSAGVT GTTGLSAEAT EITGLSAGVT GTTGLSAGVT GIAGLSAGVT
ETIGSSAGVT GTNGLSAEAT GKTGPSAGVT GTTGLSAGVT GTTGLSAGVT ETIGLSAGVT
GTIGSSAGVK GTTGQSAEVT GATGQSVGVT GTTRSSGGVT GITGLSAGLR GTTVSSAKAG
TSIPLTGKTG TTRTSVEEST TTGPSAGITG TNGLSAEMTG TNELSAGVTG TIGSSAGVTG
TTGLSVEATV TTGLSAGVTG TTVPLAGVTW TPGPSAGVTG IAALSAGVTG KSGLSAGVTG
KTGLSAGVTG TTGPSAEATG KTGLSAGVTG ITGPFAEVTG TTGLSAGVIG TTGSSAEVTG
ITGLSAGVTG KTRSSAGVTG TTGLSAKSGT SIPSAGKTGT TKTSVEESRT TRPSAGITAT
TGVPAATSPG AEGESIASTS VATGAIPRST IAPGSTTTGT TGVTTGTTLA PRSFNIGTSG
GISGKTLKPG SYVSEATTAT GTPGAGPSGG TTISSPEVST ISEVSNTGIT GVGSETSIET
GISNTATTGV APGTTLAPGS SSTEATTSIG GSASTRGGIA TEATGSTRGV RTTGSEAPEG
TSGEFSGTTI SSGGFHTEAT TLTGGRGSIG TESRAESTTS LPQSAKTRGG ILTEATSSTG
RIRATGSEAP GGTSRKFSGT TISSGGSHTE ATTLAGGRDS TESEFRTATI GVVPATTVAP
GSSKTEATTF LGVSGTTSVG RATGATTSIA GSDTSQAEHP GGTSGEFPGT TITSGDSHTE
ATALTGSRGS IGTESTVETT TYIGESGTTR GGLATATTGA FSGKTLEPGN DNTEATGSTG
GIRATRTEAP GGTSGEFPGT TFTSGGSHTE ATTFTGGKGS TGTESRAATT RAAPGTTLVP
GSSNTGATAS PGGSATTRGR ITTATTGAFS GKTLESENDN TEATSSTRGV RTTRSEAPGG
TSGEFPGTRI TSGGSYTATT RAAPGTTLAP GSSNTGATAS LGGSAMTRGR ITTATTGAFS
GKTLEPGNNN TEATSSTRGV RTTRSEAPGE ATTLTGDRSS TGSESRTATT GVAPGTTVAP
GSSKTEATTF LGVSGTTNIG RATGATTSIV GSDTSQAERP GGTTVVSPGA SSTSQSSRPG
TSVTPDSSAS ESETVTTKEF SGTTAISRTS HTGTPAASGG QATGSLTATT GVAPGTTVAP
GSSNTEATTS VGERETTKAE IITGDTGELS GTTIISENST TAGITAATGK QAGTSEVAPS
TTVAPGSFST AATTSPGASG TTGVTTTTKT TTSLGGSGTT GAEIKSATTG APGSRTGTAG
VPSATTVSPG SSNSEATTSV GESGKTGAET ITEATTSTEG TGTSGTGFKT GTSEVAPATT
VAPGSFSTAA TTSPGASGMT GVTTTTKTTT SLGGSGTTGA KIKLVGTTTT APESRTAGVP
SGTRVTPGSS NSEATTSVEE SRITRAEVIT EATTFSGGSG ATRAGLPRGT TGEFSGTNFI
SGSSNTEATT STEGTGTSGT GFKIAGITSA PGKQAGTSGV SLATTVAPGS FSTATTSSGA
SGITRAGPTS ETTTSLGGSG TTGAEIKSAA VPSGTTVAPG SSNSEATTSV GENGKTRGEI
ITDTTEGTSG KVLEPGSAHT EATTFPGGSG TTRAGPPGGT TGELSRMTII PGSSNTEATT
STKGTGTSGT GFKTGTSWVA PGTTVSPGSF STATISPGAS RTTGAAPAAE TTTSLEGGGT
TGAEIKSGAT SGVPGSKTGT AGVPSATTIA PGSSNSEATT SLGESGKTRV ETITGTTEGK
TLAAGSAHTE ATTFSGGSGS TRAGPLGGAS GTSGGYVPGR ETEPTTSIEE TGTSRTIFKT
VGITSAPGRQ AGTSVVAPST TVAPGSFSTA ATTSPGASGM TGVRTTSKTT TSLGGTGTTR
TEIKSGATTG APGIKTDIMG ESSRTTILSG SSNTEATNSI EETGTSGTGF KTAGITAAPG
KQAGTSGVAP GTTVAPGSFS TAATTSPGAS GVTGTGPTAE TTTFLGGSST TGAEIKSGAT
TGAPGSKTGT AKVLSGTTVA SGSSNSEATT FSGITEAVTV PSKNGSMTTA LGSQLSSSQT
VIPGSSGTIS HTTVAPGSSV TGTTTGASDD QVTGSKTGTT GVALSTTVAP GSSSTEATTS
TGVHRTTVVG QKTGATTRGS AKQGTRSTIE ATTSFRGTGT TGSGMNTGTT GVVSGNTISP
SSFNTEATSG TSERPNPGSE IGTTGIVSGT TVAPGSSNTE ATTSLGNGGT TEAGSKIVTT
GITTGTTIVP GSFNTKATTS TDVGVATGVG MATGITNIIS GRSQPTGSKT GYTVTGSGTT
ALPGGFRTGN TPGSTGVTSS QEGTTVVSSG ITGIPETSIS GPSKEASDKT TAPGPPTTVT
ASTGVKETSE TGVQTGSTLV TAGVPTRPQV SQPETTVVAT REVETENKTE CLASLPPAPV
CHGPLGEEKS PGDIWTANCH RGTCTDAKTI DCKPEECPSP PTCKTGEKLV KFQSNDTCCE
IGYCEPRTCL FNNTDYEIGA SFDDPSNPCV SYSCKDTGFA AVVQDCPKQT WCAEANRIYD
SKKCCYTCKN NCRSSLVNVT VIYSGCKKRV QMAKCTGECE KTAKYNYDIL LLEHSCLCCR
EENYELRDIV LDCPDGSTIP YQYKHITTCS CLDICQLYTT FMYS
