MUC1_XENLA
ID MUC1_XENLA Reviewed; 662 AA.
AC Q05049;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Integumentary mucin C.1;
DE AltName: Full=FIM-C.1;
DE Flags: Fragment;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6 AND 7).
RC TISSUE=Skin;
RX PubMed=1447205; DOI=10.1016/s0021-9258(18)35809-5;
RA Hauser F., Hoffmann W.;
RT "P-domains as shuffled cysteine-rich modules in integumentary mucin C.1
RT (FIM-C.1) from Xenopus laevis. Polydispersity and genetic polymorphism.";
RL J. Biol. Chem. 267:24620-24624(1992).
CC -!- FUNCTION: Could be involved in defense against microbial infections.
CC Protects the epithelia from external environment.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=7;
CC Comment=Additional isoforms seem to exist. Experimental confirmation
CC may be lacking for some isoforms.;
CC Name=1;
CC IsoId=Q05049-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q05049-2; Sequence=VSP_004650;
CC Name=3;
CC IsoId=Q05049-3; Sequence=VSP_004651;
CC Name=4;
CC IsoId=Q05049-4; Sequence=VSP_004647, VSP_004648;
CC Name=5;
CC IsoId=Q05049-5; Sequence=VSP_004646, VSP_004649, VSP_004650;
CC Name=6;
CC IsoId=Q05049-6; Sequence=VSP_004646, VSP_004648;
CC Name=7;
CC IsoId=Q05049-7; Sequence=VSP_004647;
CC -!- TISSUE SPECIFICITY: Skin.
CC -!- PTM: Extensively O-glycosylated.
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DR EMBL; L02115; AAA74725.1; -; mRNA.
DR PIR; A45155; A45155.
DR AlphaFoldDB; Q05049; -.
DR SMR; Q05049; -.
DR Proteomes; UP000186698; Genome assembly.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR CDD; cd00111; Trefoil; 5.
DR Gene3D; 4.10.110.10; -; 6.
DR InterPro; IPR017994; P_trefoil_chordata.
DR InterPro; IPR017957; P_trefoil_CS.
DR InterPro; IPR000519; P_trefoil_dom.
DR InterPro; IPR044913; P_trefoil_dom_sf.
DR PANTHER; PTHR13826; PTHR13826; 5.
DR Pfam; PF00088; Trefoil; 6.
DR PRINTS; PR00680; PTREFOIL.
DR SMART; SM00018; PD; 6.
DR SUPFAM; SSF57492; SSF57492; 6.
DR PROSITE; PS00025; P_TREFOIL_1; 6.
DR PROSITE; PS51448; P_TREFOIL_2; 6.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Reference proteome;
KW Repeat; Secreted.
FT CHAIN <1..662
FT /note="Integumentary mucin C.1"
FT /id="PRO_0000162379"
FT REPEAT 81..88
FT /note="1-1"
FT REPEAT 89..96
FT /note="1-2"
FT REPEAT 97..104
FT /note="1-3"
FT REPEAT 105..112
FT /note="1-4"
FT REPEAT 113..120
FT /note="1-5"
FT REPEAT 121..128
FT /note="1-6"
FT REPEAT 129..136
FT /note="1-7"
FT REPEAT 137..144
FT /note="1-8"
FT DOMAIN 160..203
FT /note="P-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT REPEAT 218..224
FT /note="2-1"
FT REPEAT 225..239
FT /note="2-2"
FT REPEAT 240..249
FT /note="2-3"
FT REPEAT 250..259
FT /note="2-4"
FT REPEAT 260..275
FT /note="2-5"
FT REPEAT 276..287
FT /note="2-6"
FT REPEAT 288..294
FT /note="2-7"
FT REPEAT 295..301
FT /note="2-8"
FT DOMAIN 305..348
FT /note="P-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DOMAIN 352..395
FT /note="P-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT REPEAT 402..411
FT /note="3-1"
FT REPEAT 412..419
FT /note="3-2"
FT REPEAT 420..431
FT /note="3-3"
FT REPEAT 432..443
FT /note="3-4"
FT REPEAT 444..453
FT /note="3-5"
FT REPEAT 454..460
FT /note="3-6"
FT REPEAT 461..472
FT /note="3-7"
FT REPEAT 473..479
FT /note="3-8"
FT REPEAT 480..491
FT /note="3-9"
FT REPEAT 492..498
FT /note="3-10"
FT REPEAT 499..515
FT /note="3-11"
FT REPEAT 516..522
FT /note="3-12"
FT DOMAIN 524..567
FT /note="P-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DOMAIN 571..614
FT /note="P-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DOMAIN 619..662
FT /note="P-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT REGION 27..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 81..144
FT /note="8 X 8 AA approximate tandem repeats, Ala/Thr-rich"
FT REGION 122..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..301
FT /note="8 X approximate tandem repeats, Thr-rich"
FT REGION 231..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..522
FT /note="12 X approximate tandem repeats, Thr-rich"
FT REGION 404..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..170
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 162..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 172..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 182..199
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 307..333
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 317..332
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 327..344
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 354..380
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 364..379
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 374..391
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 526..552
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 536..551
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 546..563
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 573..599
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 583..598
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 593..610
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 621..647
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 631..646
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DISULFID 641..658
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT VAR_SEQ 240..259
FT /note="Missing (in isoform 5 and isoform 6)"
FT /evidence="ECO:0000303|PubMed:1447205"
FT /id="VSP_004646"
FT VAR_SEQ 250..259
FT /note="Missing (in isoform 4 and isoform 7)"
FT /evidence="ECO:0000303|PubMed:1447205"
FT /id="VSP_004647"
FT VAR_SEQ 276..294
FT /note="Missing (in isoform 4 and isoform 6)"
FT /evidence="ECO:0000303|PubMed:1447205"
FT /id="VSP_004648"
FT VAR_SEQ 278
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:1447205"
FT /id="VSP_004649"
FT VAR_SEQ 306..350
FT /note="Missing (in isoform 2 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:1447205"
FT /id="VSP_004650"
FT VAR_SEQ 420..498
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:1447205"
FT /id="VSP_004651"
FT VARIANT 276
FT /note="K -> E"
FT VARIANT 354
FT /note="C -> R"
FT VARIANT 415
FT /note="T -> A"
FT NON_TER 1
SQ SEQUENCE 662 AA; 67775 MW; F085277F1ED2FD40 CRC64;
APTTAAAVAA TGKDTTAAAE GSAAAEKTAA AGEVSAPPTA AVAATGEDAT TAAATAAAET
TAAAGEAPTT TTAPATTAAG KAPTTAAATA PTTAAAGAPT TATGKAPATA AAPVPTTAAS
KAPTTAAAAT HSTAAAAAPT TAASAAKSKE RSTSSSSEEE HCHVKPSKRE MCGSKGITKK
QCKKKNCCFD PKGHGGIHCF HRKPKGHSHE EHTTTTTKAP TTIQIATTTT TPTTTTTTTK
ATPTTTTTTK ATPTTTTTTK ATTTTTTPTT TTTTTKATTT PTTTTTTTPT TTTTKATTTT
TTTSGECKME PSKREDCGYS GITESQCRTK GCCFDSSIPQ TKWCFYTLSQ VADCKVEPSQ
RVDCGFRGIT ADQCRQKNCC FDSSISGTKW CFYSTSQVAA TKTTTTPTTT TTPTTTTTTK
ATTTTPTTTT TTPTTTTTTT TTTKATTTTP TTTTPTTTTT KATTTTPTTT TTTPTTTTTK
ATTTTPTTTT TTPTTTTTKA TTTTPTTTTT TTTTTKATTT TTSGECKMEP SKRADCGYPG
ITESQCRSKG CCFDSSIPQT KWCFYSLPQV ADCKVAPSSR VDCGFGGITA DQCRQRNCCF
DSSISGTKWC FYSTSQGNAM CSGPPTKRRD CGYPGISSSV CINRGCCWDN SVMNVPWCFY
RT
