MUC21_HUMAN
ID MUC21_HUMAN Reviewed; 566 AA.
AC Q5SSG8; B0UZT7; B4DQ55; C9JMK2; D9N007; Q0VGF1; Q3B7T2; Q5SS94; Q6UXC5;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Mucin-21;
DE Short=MUC-21;
DE AltName: Full=Epiglycanin;
DE Flags: Precursor;
GN Name=MUC21; Synonyms=C6orf205; ORFNames=UNQ697/PRO1342;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ALA-98.
RC TISSUE=Esophagus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, GLYCOSYLATION, AND VARIANT ALA-98.
RC TISSUE=Cervix adenocarcinoma;
RX PubMed=17977904; DOI=10.1093/glycob/cwm118;
RA Itoh Y., Kamata-Sakurai M., Denda-Nagai K., Nagai S., Tsuiji M.,
RA Ishii-Schrade K., Okada K., Goto A., Fukayama M., Irimura T.;
RT "Identification and expression of human epiglycanin/MUC21: a novel
RT transmembrane mucin.";
RL Glycobiology 18:74-83(2008).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANTS ALA-98;
RP GLU-139; GLY-161; ASP-244; SER-253; ALA-285; ASP-289; SER-313; VAL-315;
RP GLU-319; PRO-323 AND ASN-328.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS ALA-98;
RP GLU-139; GLY-161; ASP-244; SER-253; ALA-285; ASP-289; SER-313; VAL-315;
RP GLU-319; PRO-323 AND ASN-328.
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), AND VARIANT
RP ALA-98.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17977904};
CC Single-pass type I membrane protein {ECO:0000269|PubMed:17977904};
CC Extracellular side {ECO:0000269|PubMed:17977904}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q5SSG8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5SSG8-2; Sequence=VSP_034188;
CC Name=3;
CC IsoId=Q5SSG8-3; Sequence=VSP_034189;
CC -!- TISSUE SPECIFICITY: Expressed in lung, large intestine, thymus, and
CC testis. Expressed in normal and malignant bronchial epithelial cells.
CC {ECO:0000269|PubMed:17977904}.
CC -!- PTM: O-glycosylated. {ECO:0000269|PubMed:17977904}.
CC -!- MISCELLANEOUS: Could be considered as a marker for lung carcinomas.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI05737.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Mucin database;
CC URL="http://www.medkem.gu.se/mucinbiology/databases/";
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DR EMBL; AK298642; BAG60817.1; -; mRNA.
DR EMBL; AB242595; BAF92842.1; -; mRNA.
DR EMBL; HM596784; ADJ96647.1; -; mRNA.
DR EMBL; AY358415; AAQ88781.1; -; mRNA.
DR EMBL; AL663093; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL669830; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CT009610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03353.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC105735; AAI05736.1; -; mRNA.
DR EMBL; BC105736; AAI05737.1; ALT_INIT; mRNA.
DR EMBL; BC105737; AAI05738.1; -; mRNA.
DR EMBL; BC107478; AAI07479.1; -; mRNA.
DR CCDS; CCDS34388.1; -. [Q5SSG8-1]
DR RefSeq; NP_001010909.2; NM_001010909.3. [Q5SSG8-1]
DR RefSeq; NP_001309299.1; NM_001322370.1.
DR AlphaFoldDB; Q5SSG8; -.
DR BioGRID; 134350; 1.
DR STRING; 9606.ENSP00000365473; -.
DR GlyGen; Q5SSG8; 1 site.
DR iPTMnet; Q5SSG8; -.
DR PhosphoSitePlus; Q5SSG8; -.
DR BioMuta; MUC21; -.
DR DMDM; 296439229; -.
DR MassIVE; Q5SSG8; -.
DR PaxDb; Q5SSG8; -.
DR PeptideAtlas; Q5SSG8; -.
DR PRIDE; Q5SSG8; -.
DR Antibodypedia; 65411; 7 antibodies from 6 providers.
DR DNASU; 394263; -.
DR Ensembl; ENST00000376296.3; ENSP00000365473.3; ENSG00000204544.5. [Q5SSG8-1]
DR Ensembl; ENST00000549059.2; ENSP00000447840.1; ENSG00000227506.5. [Q5SSG8-3]
DR GeneID; 394263; -.
DR KEGG; hsa:394263; -.
DR MANE-Select; ENST00000376296.3; ENSP00000365473.3; NM_001010909.5; NP_001010909.2.
DR UCSC; uc003nsh.3; human. [Q5SSG8-1]
DR CTD; 394263; -.
DR DisGeNET; 394263; -.
DR GeneCards; MUC21; -.
DR HGNC; HGNC:21661; MUC21.
DR HPA; ENSG00000204544; Group enriched (esophagus, vagina).
DR MIM; 616991; gene.
DR neXtProt; NX_Q5SSG8; -.
DR OpenTargets; ENSG00000204544; -.
DR PharmGKB; PA162396305; -.
DR VEuPathDB; HostDB:ENSG00000204544; -.
DR eggNOG; ENOG502RKVF; Eukaryota.
DR GeneTree; ENSGT00940000164618; -.
DR HOGENOM; CLU_036156_1_0_1; -.
DR InParanoid; Q5SSG8; -.
DR OMA; ESHIEST; -.
DR OrthoDB; 1589631at2759; -.
DR PathwayCommons; Q5SSG8; -.
DR Reactome; R-HSA-5083625; Defective GALNT3 causes HFTC.
DR Reactome; R-HSA-5083632; Defective C1GALT1C1 causes TNPS.
DR Reactome; R-HSA-5083636; Defective GALNT12 causes CRCS1.
DR Reactome; R-HSA-5621480; Dectin-2 family.
DR Reactome; R-HSA-913709; O-linked glycosylation of mucins.
DR Reactome; R-HSA-977068; Termination of O-glycan biosynthesis.
DR BioGRID-ORCS; 394263; 7 hits in 1061 CRISPR screens.
DR ChiTaRS; MUC21; human.
DR GenomeRNAi; 394263; -.
DR Pharos; Q5SSG8; Tbio.
DR PRO; PR:Q5SSG8; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q5SSG8; protein.
DR Bgee; ENSG00000204544; Expressed in lower esophagus mucosa and 68 other tissues.
DR ExpressionAtlas; Q5SSG8; baseline and differential.
DR GO; GO:0005796; C:Golgi lumen; TAS:Reactome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0022408; P:negative regulation of cell-cell adhesion; IBA:GO_Central.
DR InterPro; IPR033534; MUC21.
DR InterPro; IPR028199; Mucin_dom.
DR InterPro; IPR008519; Tandem-repeating_mucin.
DR PANTHER; PTHR39408; PTHR39408; 5.
DR Pfam; PF14654; Epiglycanin_C; 1.
DR Pfam; PF05647; Epiglycanin_TR; 8.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Glycoprotein; Membrane;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..566
FT /note="Mucin-21"
FT /id="PRO_0000340102"
FT TOPO_DOM 25..479
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 480..500
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 501..566
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 31..44
FT /note="1"
FT REPEAT 45..59
FT /note="2"
FT REPEAT 60..74
FT /note="3"
FT REPEAT 75..89
FT /note="4"
FT REPEAT 90..104
FT /note="5"
FT REPEAT 105..119
FT /note="6"
FT REPEAT 120..134
FT /note="7"
FT REPEAT 135..149
FT /note="8"
FT REPEAT 150..164
FT /note="9"
FT REPEAT 165..179
FT /note="10"
FT REPEAT 180..194
FT /note="11"
FT REPEAT 195..209
FT /note="12"
FT REPEAT 210..224
FT /note="13"
FT REPEAT 225..239
FT /note="14"
FT REPEAT 244..254
FT /note="15"
FT REPEAT 255..269
FT /note="16"
FT REPEAT 270..284
FT /note="17"
FT REPEAT 285..299
FT /note="18"
FT REPEAT 300..314
FT /note="19"
FT REPEAT 315..329
FT /note="20"
FT REPEAT 330..344
FT /note="21"
FT REPEAT 345..359
FT /note="22"
FT REPEAT 360..374
FT /note="23"
FT REPEAT 375..389
FT /note="24"
FT REPEAT 390..404
FT /note="25"
FT REPEAT 405..419
FT /note="26"
FT REPEAT 420..434
FT /note="27"
FT REPEAT 435..449
FT /note="28"
FT REGION 25..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 31..435
FT /note="28 X 15 AA approximate tandem repeats"
FT REGION 106..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..566
FT /note="Cytoplasmic tail"
FT SITE 502..503
FT /note="Cleavage"
FT /evidence="ECO:0000255"
FT CARBOHYD 25
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 134
FT /note="T -> TVTNSGSSVTSSGASTATNSESSTVSSRAST (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_034188"
FT VAR_SEQ 188..337
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034189"
FT VARIANT 98
FT /note="V -> A (in dbSNP:rs1634730)"
FT /evidence="ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:14574404, ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17977904"
FT /id="VAR_060457"
FT VARIANT 139
FT /note="D -> E (in dbSNP:rs9262324)"
FT /evidence="ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:14574404"
FT /id="VAR_043995"
FT VARIANT 161
FT /note="E -> G (in dbSNP:rs9262337)"
FT /evidence="ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:14574404"
FT /id="VAR_043996"
FT VARIANT 244
FT /note="E -> D (in dbSNP:rs113760893)"
FT /evidence="ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:14574404"
FT /id="VAR_043997"
FT VARIANT 253
FT /note="G -> S (in dbSNP:rs11756238)"
FT /evidence="ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:14574404"
FT /id="VAR_043998"
FT VARIANT 282
FT /note="I -> T (in dbSNP:rs9262368)"
FT /id="VAR_060458"
FT VARIANT 282
FT /note="I -> V (in dbSNP:rs9262367)"
FT /id="VAR_060459"
FT VARIANT 285
FT /note="V -> A (in dbSNP:rs9262370)"
FT /evidence="ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:14574404"
FT /id="VAR_043999"
FT VARIANT 289
FT /note="E -> D (in dbSNP:rs41288665)"
FT /evidence="ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:14574404"
FT /id="VAR_044000"
FT VARIANT 313
FT /note="N -> S (in dbSNP:rs9262379)"
FT /evidence="ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:14574404"
FT /id="VAR_044001"
FT VARIANT 315
FT /note="A -> V (in dbSNP:rs41288675)"
FT /evidence="ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:14574404"
FT /id="VAR_044002"
FT VARIANT 319
FT /note="D -> E (in dbSNP:rs9262380)"
FT /evidence="ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:14574404"
FT /id="VAR_044003"
FT VARIANT 323
FT /note="T -> P (in dbSNP:rs41288679)"
FT /evidence="ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:14574404"
FT /id="VAR_044004"
FT VARIANT 328
FT /note="S -> N (in dbSNP:rs41288681)"
FT /evidence="ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:14574404"
FT /id="VAR_044005"
FT CONFLICT 143
FT /note="T -> L (in Ref. 3; AAQ88781 and 4; CT009610)"
FT /evidence="ECO:0000305"
FT CONFLICT 180
FT /note="A -> V (in Ref. 4; CR759772)"
FT /evidence="ECO:0000305"
FT CONFLICT 248
FT /note="P -> V (in Ref. 3; AAQ88781 and 4; CT009610)"
FT /evidence="ECO:0000305"
FT CONFLICT 268
FT /note="G -> S (in Ref. 3; AAQ88781 and 4; CT009610)"
FT /evidence="ECO:0000305"
FT CONFLICT 278
FT /note="V -> T (in Ref. 3; AAQ88781 and 4; CT009610)"
FT /evidence="ECO:0000305"
FT CONFLICT 282
FT /note="I -> A (in Ref. 3; AAQ88781 and 4; CT009610)"
FT /evidence="ECO:0000305"
FT CONFLICT 293
FT /note="P -> T (in Ref. 3; AAQ88781 and 4; CT009610)"
FT /evidence="ECO:0000305"
FT CONFLICT 298
FT /note="N -> G (in Ref. 3; AAQ88781 and 4; CT009610)"
FT /evidence="ECO:0000305"
FT CONFLICT 308
FT /note="T -> V (in Ref. 3; AAQ88781 and 4; CT009610)"
FT /evidence="ECO:0000305"
FT CONFLICT 312
FT /note="A -> I (in Ref. 3; AAQ88781 and 4; CT009610)"
FT /evidence="ECO:0000305"
FT CONFLICT 343
FT /note="S -> N (in Ref. 3; AAQ88781 and 4; CT009610)"
FT /evidence="ECO:0000305"
FT CONFLICT 353
FT /note="T -> V (in Ref. 3; AAQ88781 and 4; CT009610)"
FT /evidence="ECO:0000305"
FT CONFLICT 364
FT /note="G -> E (in Ref. 3; AAQ88781 and 4; CT009610)"
FT /evidence="ECO:0000305"
FT CONFLICT 372
FT /note="T -> V (in Ref. 3; AAQ88781 and 4; CT009610)"
FT /evidence="ECO:0000305"
FT CONFLICT 383
FT /note="V -> T (in Ref. 3; AAQ88781 and 4; CT009610)"
FT /evidence="ECO:0000305"
FT CONFLICT 392
FT /note="T -> N (in Ref. 3; AAQ88781 and 4; CT009610)"
FT /evidence="ECO:0000305"
FT CONFLICT 394
FT /note="E -> D (in Ref. 3; AAQ88781 and 4; CT009610)"
FT /evidence="ECO:0000305"
FT CONFLICT 401
FT /note="G -> E (in Ref. 3; AAQ88781 and 4; CT009610)"
FT /evidence="ECO:0000305"
FT CONFLICT 417
FT /note="A -> I (in Ref. 3; AAQ88781 and 4; CT009610)"
FT /evidence="ECO:0000305"
FT CONFLICT 420
FT /note="A -> V (in Ref. 3; AAQ88781 and 4; CT009610)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 566 AA; 54228 MW; 196A43738C47F9C7 CRC64;
MKMQKGNVLL MFGLLLHLEA ATNSNETSTS ANTGSSVISS GASTATNSGS SVTSSGVSTA
TISGSSVTSN GVSIVTNSEF HTTSSGISTA TNSEFSTVSS GISIATNSES STTSSGASTA
TNSESSTPSS GASTATNSDS STTSSGASTA TNSDSSTTSS EASTATNSES STTSSGASTA
TNSESSTVSS RASTATNSES STTSSGASTA TNSESRTTSN GAGTATNSES STTSSGASTA
TNSESSTPSS GAGTATNSES STTSSGAGTA TNSESSTVSS GISTVTNSES STPSSGANTA
TNSESSTTSS GANTATNSDS STTSSGASTA TNSESSTTSS GASTATNSES STTSSGASTA
TNSGSSTTSS GTSTATNSES STVSSGASTA TTSESSTTSS GASTATNSES STVSSGASTA
TNSESSTTSS GANTATNSGS SVTSAGSGTA ALTGMHTTSH SASTAVSEAK PGGSLVPWEI
FLITLVSVVA AVGLFAGLFF CVRNSLSLRN TFNTAVYHPH GLNHGLGPGP GGNHGAPHRP
RWSPNWFWRR PVSSIAMEMS GRNSGP
