MUC22_HUMAN
ID MUC22_HUMAN Reviewed; 1773 AA.
AC E2RYF6; H3BQR8;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Mucin-22;
DE AltName: Full=Panbronchiolitis-related mucin-like protein 1;
DE Flags: Precursor;
GN Name=MUC22; Synonyms=G4, PBMUCL1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, TISSUE SPECIFICITY, AND VARIANT
RP ASP-1712.
RC TISSUE=Lung;
RX PubMed=20981447; DOI=10.1007/s00439-010-0906-4;
RA Hijikata M., Matsushita I., Tanaka G., Tsuchiya T., Itoh H., Tokunaga K.,
RA Ohashi J., Homma S., Kobashi Y., Taguchi Y., Azuma A., Kudoh S., Keicho N.;
RT "Molecular cloning of two novel mucin-like genes in the disease-
RT susceptibility locus for diffuse panbronchiolitis.";
RL Hum. Genet. 129:117-128(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in lung by serous cells of the submucosal
CC gland (at protein level). Detected in the placenta, lung and testis.
CC {ECO:0000269|PubMed:20981447}.
CC -!- INDUCTION: Up-regulated by poly(I:C). {ECO:0000269|PubMed:20981447}.
CC -!- WEB RESOURCE: Name=Mucin database;
CC URL="http://www.medkem.gu.se/mucinbiology/databases/";
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DR EMBL; AB560770; BAJ24154.1; -; mRNA.
DR EMBL; AB600271; BAJ33462.1; -; mRNA.
DR EMBL; AB600272; BAJ33463.1; -; mRNA.
DR EMBL; AL669830; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS59003.1; -.
DR RefSeq; NP_001185744.1; NM_001198815.1.
DR RefSeq; NP_001305413.1; NM_001318484.1.
DR AlphaFoldDB; E2RYF6; -.
DR SMR; E2RYF6; -.
DR STRING; 9606.ENSP00000455906; -.
DR iPTMnet; E2RYF6; -.
DR PhosphoSitePlus; E2RYF6; -.
DR BioMuta; MUC22; -.
DR PaxDb; E2RYF6; -.
DR PeptideAtlas; E2RYF6; -.
DR PRIDE; E2RYF6; -.
DR DNASU; 100507679; -.
DR Ensembl; ENST00000561890.1; ENSP00000455906.1; ENSG00000261272.1.
DR GeneID; 100507679; -.
DR KEGG; hsa:100507679; -.
DR MANE-Select; ENST00000561890.1; ENSP00000455906.1; NM_001395414.1; NP_001382343.1.
DR UCSC; uc063mxr.1; human.
DR CTD; 100507679; -.
DR DisGeNET; 100507679; -.
DR GeneCards; MUC22; -.
DR HGNC; HGNC:39755; MUC22.
DR HPA; ENSG00000261272; Tissue enriched (esophagus).
DR MIM; 613917; gene.
DR neXtProt; NX_E2RYF6; -.
DR OpenTargets; ENSG00000261272; -.
DR VEuPathDB; HostDB:ENSG00000261272; -.
DR eggNOG; ENOG502RYA8; Eukaryota.
DR GeneTree; ENSGT00940000164570; -.
DR HOGENOM; CLU_239049_0_0_1; -.
DR InParanoid; E2RYF6; -.
DR OMA; VYTTGSE; -.
DR OrthoDB; 1320016at2759; -.
DR BioGRID-ORCS; 100507679; 10 hits in 1060 CRISPR screens.
DR GenomeRNAi; 100507679; -.
DR Pharos; E2RYF6; Tdark.
DR PRO; PR:E2RYF6; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; E2RYF6; protein.
DR Bgee; ENSG00000261272; Expressed in lower esophagus mucosa and 13 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR028199; Mucin_dom.
DR Pfam; PF14654; Epiglycanin_C; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..1773
FT /note="Mucin-22"
FT /id="PRO_0000410470"
FT TOPO_DOM 27..1660
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1661..1681
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1682..1773
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 61..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 153..1514
FT /note="124 X 10 AA approximate repeats"
FT REGION 176..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 372..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 434..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 590..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..1026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1064..1485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1603..1639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 1712
FT /note="N -> D (in dbSNP:rs4248153)"
FT /evidence="ECO:0000269|PubMed:20981447"
FT /id="VAR_065357"
FT CONFLICT 57
FT /note="S -> T (in Ref. 1; BAJ24154/BAJ33462/BAJ33463)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1773 AA; 173478 MW; A25C9C6C4A5AC924 CRC64;
MRRGNISPAF WFLWLLLFGL LGPSSENTTA FTKGSDTTTA SITGSETTMA STMASTSALT
TGSKITTDST TGSETTSAST MASTAAFTTG SETNTASTTD SGTTIASTRT FTTGSDTTTG
STAGSETIVA STTVSGTTTT FTIASTTVPE TTMASSTTST AGSEKTMASS IISETTMAST
TGSETATVST TGSETTTTST ASSEATKVST TGSETTTAST AGSETTTTST SMAGSEATTT
STADSKVITA SSMSSETTVA PAAGSNTTTA STTGSETTTI LIKASETTTA STAGSETTTP
SPTGSQTTIV SISGSEITTT STAGSENTTV SSAGSGTTTA SMAGSETTVS TAGSETTTVS
ITGTETTMVS AMGSETTTNS TTSSETTVTS TAGSETTTVS TVGSETTTAY TADSETTAAS
TTGSEMTTVF TAGSETITPS TAGSETTTVS TAGSETTTVS TTGSETTTAS TAHSETTAAS
TMGSETTKVS TAGSETTVST AGSETTAAST EDSETNTAFT EDSKTTTAST TGFETTAAST
TGSEPTMAST MGSETTMAST IGPETTKVST ASSEVTTVFA AGSETIRAST VGSETTTVST
TGSETTTASI MGSETSTDST TGSETTTAST EGSETTTAST EGSEATTVST TGSETTTVSI
TDSETTTTCT EGSEMTAVST TVFETTTAST EGSEITIAST SDSETTTAST EGSETTTVTT
AGSETKTAYT TGSETTTASN TGLETTTVFT IGSDTTTAST EGSETTAVSA TGSEMTTVST
EGSENTTVST TGSETTTVST TGLETTTTST EGSEMTTVST TGAETTTDST EGSGTTAAST
AGSETTTVST ADSENTTAST ADSETTSAST TGSETTTAST TSSETTTAST EGSETTTVST
TDSETTMVST TGSERTITST EGSETTTVSA TGSETTVSTE GSGTTTVSIT GSETTKVSTT
GSETTTTSTE GSEITTASIT GSETTTASTE GSETTTASTE GSETTSASTT GSETTTASTT
SSETTMASIM GSETTMASTI GSETTKVSTA SSKMTTVFTE NSETTIASTT ASETTTVSTA
GSETIPASTA GSETTTTTST EGSETTTAST EGSETTTAST ESSETTTATT IGSETTTAST
EGSETTTTST EGSETTTAST EGSEITTVST TGSETTTAST EGSETTTAST EGSELTTVST
TGSETITVSA EGSETTTVTT MGSETTTAST AGSETTTVST AGSETTTASI EGSETTTVSS
TGSETTTVST TGTETTITST EGSETTTVTT AGSETTAVYT TGSETTTTST EGSETTTVST
TGSETTTAST ADLETTTVST SGSGTTTAST AGSETTTVYI TGSKTTTAST EGSEATTVST
TSSETTTAST TGSEMTTVFT TVSETTTVST IGSEATTSSA AGSEATTTST EGSETTTAST
AGSETTTAST AGSETTTAST SGSETNTACT TGSETSTPSS AGSETNTAFI IGSESTIAST
ASLEPTATSL TGSETTTVSI TASGATAAST TVSSTTFVLT KATDVSIQPI TNTPMSGTRT
TGTRLTASSS VTMAPGMDFT ASAASHTVPG IVLNTSGLGT STMGASSTTS AHGVRTTTGS
TREPTSSTFQ ETGPVSMGTN TVSMSHTPTN VIKPSGYLQP WAIILISLAA VVAAVGLSVG
LSFCLRNLFF PLRYCGIYYP HGHSHSLGLD LNLGLGSGTF HSLGNALVHG GELEMGHGGT
HGFGYGVGHG LSHIHGDGYG VNHGGHYGHG GGH
