MUC24_BOVIN
ID MUC24_BOVIN Reviewed; 198 AA.
AC Q2YDH0;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Sialomucin core protein 24;
DE Short=MUC-24;
DE AltName: Full=Endolyn;
DE AltName: CD_antigen=CD164;
DE Flags: Precursor;
GN Name=CD164;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sialomucin that may play a key role in hematopoiesis. May be
CC involved in cell adhesion. Promotes myogenesis by enhancing CXCR4-
CC dependent cell motility. Positively regulates myoblast migration and
CC promotes myoblast fusion into myotubes (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CXCR4. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000305}; Single-pass type
CC I membrane protein {ECO:0000305}. Endosome membrane {ECO:0000250};
CC Single-pass type I membrane protein {ECO:0000250}. Cell membrane
CC {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
CC -!- PTM: Highly N- and O-glycosylated; contains sialic acid. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CD164 family. {ECO:0000305}.
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DR EMBL; BC110225; AAI10226.1; -; mRNA.
DR RefSeq; NP_001039506.1; NM_001046041.1.
DR AlphaFoldDB; Q2YDH0; -.
DR SMR; Q2YDH0; -.
DR STRING; 9913.ENSBTAP00000023937; -.
DR PaxDb; Q2YDH0; -.
DR Ensembl; ENSBTAT00000023937; ENSBTAP00000023937; ENSBTAG00000017992.
DR GeneID; 509820; -.
DR KEGG; bta:509820; -.
DR CTD; 8763; -.
DR VEuPathDB; HostDB:ENSBTAG00000017992; -.
DR VGNC; VGNC:27004; CD164.
DR eggNOG; ENOG502S7HA; Eukaryota.
DR GeneTree; ENSGT00530000063929; -.
DR HOGENOM; CLU_101414_0_0_1; -.
DR InParanoid; Q2YDH0; -.
DR OMA; CYWIECK; -.
DR OrthoDB; 1643926at2759; -.
DR TreeFam; TF333380; -.
DR Proteomes; UP000009136; Chromosome 9.
DR Bgee; ENSBTAG00000017992; Expressed in spermatocyte and 108 other tissues.
DR ExpressionAtlas; Q2YDH0; baseline and differential.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IEA:Ensembl.
DR GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR InterPro; IPR007947; CD164_MGC24.
DR PANTHER; PTHR11337; PTHR11337; 1.
DR Pfam; PF05283; MGC-24; 1.
DR PRINTS; PR01701; CD164ANTIGEN.
PE 2: Evidence at transcript level;
KW Cell adhesion; Cell membrane; Endosome; Glycoprotein; Lysosome; Membrane;
KW Myogenesis; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..198
FT /note="Sialomucin core protein 24"
FT /id="PRO_0000383340"
FT TOPO_DOM 25..163
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..198
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 32..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 192..198
FT /note="Required for endosomal and lysosomal localization"
FT /evidence="ECO:0000250"
FT CARBOHYD 26
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 32
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 79
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 96
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 106
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 122
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 147
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 198 AA; 20347 MW; E05B2E0852D70579 CRC64;
MSGLSRPLLL AVGCLAALCV ITAAGNTTLA PNVTTASSPP PTTTTVPVSP TTLSPLPVTT
PAPDICGSRN SCVSCVDGNA TCFWIECKGK SYCSDNSTAG DCKVVNTTGF CSVPTTTPTP
TNSTAKTTTL PSTTTTSTTA TTSGTTNTTL SPTIQPTRKS TFDAASFIGG IVLVLGVQAV
IFFLYKFCKS KERNYHTL
