MUC24_RAT
ID MUC24_RAT Reviewed; 195 AA.
AC Q9QX82;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Sialomucin core protein 24;
DE Short=MUC-24;
DE AltName: Full=Endolyn;
DE AltName: Full=Multi-glycosylated core protein 24;
DE Short=MGC-24;
DE Short=MGC-24v;
DE Flags: Precursor;
GN Name=Cd164;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 102-112 AND 189-195,
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RX PubMed=10620506; DOI=10.1042/bj3450287;
RA Ihrke G., Gray S.R., Luzio J.P.;
RT "Endolyn is a mucin-like type I membrane protein targeted to lysosomes by
RT its cytoplasmic tail.";
RL Biochem. J. 345:287-296(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Sialomucin that may play a key role in hematopoiesis. May be
CC involved in cell adhesion. Promotes myogenesis by enhancing CXCR4-
CC dependent cell motility. Positively regulates myoblast migration and
CC promotes myoblast fusion into myotubes (By similarity).
CC {ECO:0000250|UniProtKB:Q9R0L9}.
CC -!- SUBUNIT: Interacts with CXCR4. {ECO:0000250|UniProtKB:Q04900}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q04900};
CC Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q04900}.
CC Lysosome membrane {ECO:0000269|PubMed:10620506}; Single-pass type I
CC membrane protein {ECO:0000269|PubMed:10620506}. Endosome membrane
CC {ECO:0000269|PubMed:10620506}; Single-pass type I membrane protein
CC {ECO:0000269|PubMed:10620506}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. Expressed at highest levels in the
CC liver, kidney, lung and intestine. {ECO:0000269|PubMed:10620506}.
CC -!- PTM: Highly N- and O-glycosylated; contains sialic acid. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CD164 family. {ECO:0000305}.
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DR EMBL; AJ238574; CAB66090.1; -; mRNA.
DR EMBL; CH474025; EDL99731.1; -; Genomic_DNA.
DR EMBL; BC062064; AAH62064.1; -; mRNA.
DR RefSeq; NP_114000.1; NM_031812.1.
DR AlphaFoldDB; Q9QX82; -.
DR SMR; Q9QX82; -.
DR STRING; 10116.ENSRNOP00000000334; -.
DR GlyGen; Q9QX82; 8 sites.
DR PaxDb; Q9QX82; -.
DR Ensembl; ENSRNOT00000101562; ENSRNOP00000092693; ENSRNOG00000000304.
DR GeneID; 83689; -.
DR KEGG; rno:83689; -.
DR CTD; 8763; -.
DR RGD; 70942; Cd164.
DR eggNOG; ENOG502S7HA; Eukaryota.
DR GeneTree; ENSGT00530000063929; -.
DR HOGENOM; CLU_101414_0_0_1; -.
DR InParanoid; Q9QX82; -.
DR OMA; CYWIECK; -.
DR OrthoDB; 1643926at2759; -.
DR PhylomeDB; Q9QX82; -.
DR TreeFam; TF333380; -.
DR PRO; PR:Q9QX82; -.
DR Proteomes; UP000002494; Chromosome 20.
DR Proteomes; UP000234681; Chromosome 20.
DR Bgee; ENSRNOG00000000304; Expressed in liver and 19 other tissues.
DR ExpressionAtlas; Q9QX82; baseline and differential.
DR Genevisible; Q9QX82; RN.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0005768; C:endosome; IDA:RGD.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IDA:RGD.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0007155; P:cell adhesion; ISO:RGD.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; ISO:RGD.
DR GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR InterPro; IPR007947; CD164_MGC24.
DR PANTHER; PTHR11337; PTHR11337; 1.
DR Pfam; PF05283; MGC-24; 1.
DR PRINTS; PR01701; CD164ANTIGEN.
PE 1: Evidence at protein level;
KW Cell adhesion; Cell membrane; Direct protein sequencing; Endosome;
KW Glycoprotein; Lysosome; Membrane; Myogenesis; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..195
FT /note="Sialomucin core protein 24"
FT /id="PRO_5000065184"
FT TOPO_DOM 24..160
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 182..195
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 27..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 114..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..195
FT /note="Required for endosomal and lysosomal localization"
FT CARBOHYD 26
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 32
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 68
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 74
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 86
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 118
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 144
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 195 AA; 20476 MW; 6DB7F015B4238C45 CRC64;
MSGASRGLFW AATCLAALCL SAAQSNSSAS PNVTDPPTTT SKVVPTTLTT TKPPETCESF
NSCVSCVNAT LTNNITCVWL DCHEANKTYC SSELVSNCTQ KTSTDSCSVI PTTPVPTNST
AKPTTRPSSP TPTPSVVTSA GATNTTVTPT SQPERKSTFD AASFIGGIVL VLGVQAVIFF
LYKFCKSKER NYHTL
