MUC3A_HUMAN
ID MUC3A_HUMAN Reviewed; 3323 AA.
AC Q02505; A6NP22; O14650; O14651; O43418; O43421; Q02506; Q6W763; Q9H3Q7;
AC Q9UKW9; Q9UN93; Q9UN94; Q9UN95;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2016, sequence version 3.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Mucin-3A {ECO:0000305};
DE Short=MUC-3A {ECO:0000305};
DE AltName: Full=Intestinal mucin-3A {ECO:0000305|PubMed:12958310};
DE Flags: Precursor;
GN Name=MUC3A {ECO:0000312|HGNC:HGNC:7513};
GN Synonyms=MUC3 {ECO:0000303|PubMed:10405327};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-340 (ISOFORM 1).
RX PubMed=12958310; DOI=10.1074/jbc.m305769200;
RA Gum J.R. Jr., Hicks J.W., Crawley S.C., Dahl C.M., Yang S.C.,
RA Roberton A.M., Kim Y.S.;
RT "Initiation of transcription of the MUC3A human intestinal mucin from a
RT TATA-less promoter and comparison with the MUC3B amino terminus.";
RL J. Biol. Chem. 278:49600-49609(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1003-1515 AND 1530-1969 (ISOFORM 1), AND
RP NUCLEOTIDE SEQUENCE [MRNA] OF 2097-3323 (ISOFORM 2).
RX PubMed=9334251; DOI=10.1074/jbc.272.42.26678;
RA Gum J.R. Jr., Ho J.J.L., Pratt W.S., Hicks J.W., Hill A.S., Vinall L.E.,
RA Roberton A.M., Swallow D.M., Kim Y.S.;
RT "MUC3 human intestinal mucin. Analysis of gene structure, the carboxyl
RT terminus, and a novel upstream repetitive region.";
RL J. Biol. Chem. 272:26678-26686(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2097-3323 (ISOFORM 1), ALTERNATIVE
RP SPLICING (ISOFORMS 2; 3 AND 4), VARIANT ASN-3299, AND SUBCELLULAR LOCATION.
RC TISSUE=Intestine;
RX PubMed=10512748; DOI=10.1006/bbrc.1999.1466;
RA Crawley S.C., Gum J.R. Jr., Hicks J.W., Pratt W.S., Aubert J.-P.,
RA Swallow D.M., Kim Y.S.;
RT "Genomic organization and structure of the 3' region of human MUC3:
RT alternative splicing predicts membrane-bound and soluble forms of the
RT mucin.";
RL Biochem. Biophys. Res. Commun. 263:728-736(1999).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2447-3323 (ISOFORM 1), TISSUE
RP SPECIFICITY, AND VARIANTS ALA-3120; ASN-3299 AND HIS-3299.
RX PubMed=11289722; DOI=10.1007/s100380170118;
RA Kyo K., Muto T., Nagawa H., Lathrop G.M., Nakamura Y.;
RT "Associations of distinct variants of the intestinal mucin gene MUC3A with
RT ulcerative colitis and Crohn's disease.";
RL J. Hum. Genet. 46:5-20(2001).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 2958-3323 (ISOFORMS 1; 2 AND 5), AND
RP FUNCTION.
RC TISSUE=Colon mucosa, and Small intestine;
RX PubMed=10405327; DOI=10.1006/bbrc.1999.1001;
RA Williams S.J., Munster D.J., Quin R.J., Gotley D.C., McGuckin M.A.;
RT "The MUC3 gene encodes a transmembrane mucin and is alternatively
RT spliced.";
RL Biochem. Biophys. Res. Commun. 261:83-89(1999).
RN [7]
RP PARTIAL NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Small intestine;
RX PubMed=2393399; DOI=10.1016/0006-291x(90)91408-k;
RA Gum J.R. Jr., Hicks J.W., Swallow D.M., Lagace R.L., Byrd J.C.,
RA Lamport D.T.A., Siddiki B., Kim Y.S.;
RT "Molecular cloning of cDNAs derived from a novel human intestinal mucin
RT gene.";
RL Biochem. Biophys. Res. Commun. 171:407-415(1990).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC -!- FUNCTION: Major glycoprotein component of a variety of mucus gels.
CC Thought to provide a protective, lubricating barrier against particles
CC and infectious agents at mucosal surfaces. May be involved in ligand
CC binding and intracellular signaling. {ECO:0000269|PubMed:10405327}.
CC -!- SUBCELLULAR LOCATION: [Isoform 1]: Membrane; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- SUBCELLULAR LOCATION: [Isoform 2]: Secreted
CC {ECO:0000303|PubMed:10512748}.
CC -!- SUBCELLULAR LOCATION: [Isoform 3]: Secreted
CC {ECO:0000303|PubMed:10512748}.
CC -!- SUBCELLULAR LOCATION: [Isoform 4]: Secreted
CC {ECO:0000303|PubMed:10512748}.
CC -!- SUBCELLULAR LOCATION: [Isoform 5]: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Comment=Additional isoforms seem to exist.;
CC Name=1;
CC IsoId=Q02505-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q02505-2; Sequence=VSP_023229, VSP_023231;
CC Name=3;
CC IsoId=Q02505-3; Sequence=VSP_023230, VSP_023233;
CC Name=4;
CC IsoId=Q02505-4; Sequence=VSP_023232, VSP_023234;
CC Name=5;
CC IsoId=Q02505-5; Sequence=VSP_023235;
CC -!- TISSUE SPECIFICITY: Broad specificity; small intestine, colon, colonic
CC tumors, heart, liver, thymus, prostate, pancreas and gall bladder.
CC {ECO:0000269|PubMed:11289722}.
CC -!- PTM: Highly O-glycosylated and probably also N-glycosylated.
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA63772.1; Type=Miscellaneous discrepancy; Note=This sequence is incomplete at 5' and 3' ends and extensively differs from that shown.; Evidence={ECO:0000305};
CC Sequence=AAA63773.1; Type=Miscellaneous discrepancy; Note=This sequence is incomplete at 5' and 3' ends and extensively differs from that shown.; Evidence={ECO:0000305};
CC Sequence=AAC02271.1; Type=Frameshift; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Mucin database;
CC URL="http://www.medkem.gu.se/mucinbiology/databases/";
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DR EMBL; AC105446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC118759; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC254629; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY307930; AAQ73824.1; -; Genomic_DNA.
DR EMBL; AF007190; AAC02268.1; -; mRNA.
DR EMBL; AF007193; AAC02271.1; ALT_FRAME; mRNA.
DR EMBL; AF007194; AAC02272.1; -; mRNA.
DR EMBL; AF113616; AAF13032.1; -; Genomic_DNA.
DR EMBL; AB038782; BAB12116.1; -; Genomic_DNA.
DR EMBL; AF143371; AAD45882.1; -; mRNA.
DR EMBL; AF143372; AAD45883.1; -; mRNA.
DR EMBL; AF143373; AAD45884.1; -; mRNA.
DR EMBL; M55405; AAA63772.1; ALT_SEQ; mRNA.
DR EMBL; M55406; AAA63773.1; ALT_SEQ; mRNA.
DR CCDS; CCDS78262.1; -. [Q02505-1]
DR PIR; A35690; A35690.
DR PIR; B35690; B35690.
DR RefSeq; NP_005951.1; NM_005960.1. [Q02505-1]
DR IntAct; Q02505; 1.
DR STRING; 9606.ENSP00000368771; -.
DR MEROPS; S71.002; -.
DR iPTMnet; Q02505; -.
DR PhosphoSitePlus; Q02505; -.
DR BioMuta; MUC3A; -.
DR DMDM; 126302571; -.
DR jPOST; Q02505; -.
DR MassIVE; Q02505; -.
DR PaxDb; Q02505; -.
DR PeptideAtlas; Q02505; -.
DR PRIDE; Q02505; -.
DR Antibodypedia; 1458; 370 antibodies from 21 providers.
DR DNASU; 4584; -.
DR Ensembl; ENST00000379458.9; ENSP00000368771.5; ENSG00000169894.18. [Q02505-1]
DR Ensembl; ENST00000483366.5; ENSP00000483541.1; ENSG00000169894.18. [Q02505-5]
DR GeneID; 4584; -.
DR KEGG; hsa:4584; -.
DR MANE-Select; ENST00000379458.9; ENSP00000368771.5; NM_005960.2; NP_005951.1.
DR UCSC; uc033aad.2; human.
DR UCSC; uc064gjo.1; human. [Q02505-1]
DR CTD; 4584; -.
DR DisGeNET; 4584; -.
DR GeneCards; MUC3A; -.
DR HGNC; HGNC:7513; MUC3A.
DR HPA; ENSG00000169894; Tissue enhanced (gallbladder, intestine).
DR MIM; 158371; gene.
DR neXtProt; NX_Q02505; -.
DR OpenTargets; ENSG00000169894; -.
DR VEuPathDB; HostDB:ENSG00000169894; -.
DR eggNOG; ENOG502SKUJ; Eukaryota.
DR GeneTree; ENSGT00940000154419; -.
DR HOGENOM; CLU_299695_0_0_1; -.
DR InParanoid; Q02505; -.
DR OMA; DTTHPPA; -.
DR PathwayCommons; Q02505; -.
DR Reactome; R-HSA-5083625; Defective GALNT3 causes HFTC.
DR Reactome; R-HSA-5083632; Defective C1GALT1C1 causes TNPS.
DR Reactome; R-HSA-5083636; Defective GALNT12 causes CRCS1.
DR Reactome; R-HSA-5621480; Dectin-2 family.
DR Reactome; R-HSA-913709; O-linked glycosylation of mucins.
DR Reactome; R-HSA-977068; Termination of O-glycan biosynthesis.
DR SignaLink; Q02505; -.
DR BioGRID-ORCS; 4584; 0 hits in 144 CRISPR screens.
DR ChiTaRS; MUC3A; human.
DR GenomeRNAi; 4584; -.
DR Pharos; Q02505; Tbio.
DR PRO; PR:Q02505; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q02505; protein.
DR Bgee; ENSG00000169894; Expressed in mucosa of transverse colon and 117 other tissues.
DR ExpressionAtlas; Q02505; baseline and differential.
DR Genevisible; Q02505; HS.
DR GO; GO:0005576; C:extracellular region; NAS:UniProtKB.
DR GO; GO:0005796; C:Golgi lumen; TAS:Reactome.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0030197; F:extracellular matrix constituent, lubricant activity; NAS:UniProtKB.
DR GO; GO:0005201; F:extracellular matrix structural constituent; NAS:UniProtKB.
DR CDD; cd00055; EGF_Lam; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00200; SEA; 1.
DR SUPFAM; SSF82671; SSF82671; 1.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS50024; SEA; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Disulfide bond; EGF-like domain; Glycoprotein;
KW Membrane; Reference proteome; Repeat; Secreted; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..15
FT /evidence="ECO:0000255"
FT CHAIN 16..3323
FT /note="Mucin-3A"
FT /id="PRO_0000158955"
FT TRANSMEM 3227..3247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 1893..1910
FT /note="1"
FT REPEAT 1911..1927
FT /note="2"
FT REPEAT 1928..1944
FT /note="3"
FT REPEAT 1945..1961
FT /note="4"
FT REPEAT 1962..1978
FT /note="5"
FT REPEAT 1979..1995
FT /note="6"
FT REPEAT 1996..2012
FT /note="7"
FT REPEAT 2013..2029
FT /note="8"
FT REPEAT 2030..2046
FT /note="9"
FT REPEAT 2047..2062
FT /note="10"
FT REPEAT 2063..2079
FT /note="11"
FT REPEAT 2080..2096
FT /note="12"
FT REPEAT 2097..2113
FT /note="13"
FT REPEAT 2114..2130
FT /note="14"
FT REPEAT 2131..2147
FT /note="15"
FT REPEAT 2148..2164
FT /note="16"
FT REPEAT 2165..2191
FT /note="17"
FT REPEAT 2192..2208
FT /note="18"
FT REPEAT 2209..2225
FT /note="19"
FT REPEAT 2226..2242
FT /note="20"
FT REPEAT 2243..2259
FT /note="21"
FT REPEAT 2260..2276
FT /note="22"
FT REPEAT 2277..2293
FT /note="23"
FT REPEAT 2294..2310
FT /note="24"
FT REPEAT 2311..2327
FT /note="25"
FT REPEAT 2328..2344
FT /note="26"
FT REPEAT 2345..2361
FT /note="27"
FT REPEAT 2362..2378
FT /note="28"
FT REPEAT 2379..2395
FT /note="29"
FT REPEAT 2396..2412
FT /note="30"
FT REPEAT 2413..2429
FT /note="31"
FT REPEAT 2430..2446
FT /note="32"
FT DOMAIN 2976..3009
FT /note="EGF-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 3018..3143
FT /note="SEA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT REGION 218..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 270..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 325..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 539..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 734..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 909..991
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1170..1201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1318..1356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1380..1442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1484..1509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1714..1746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1793..1844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1893..2446
FT /note="32 X approximate tandem repeats, Ser/Thr-rich"
FT REGION 1900..2056
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2100..2447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2464..2508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2578..2608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2631..2656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2834..2858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2897..2937
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 2980..2986
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2999..3008
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT VAR_SEQ 3019..3063
FT /note="VVETEVGMEVSVDQQFSPDLNDNTSQAYRDFNKTFWNQMQKIFAD -> AED
FT FCRHAGLHLQGCGDPVPEEWQHRGGLPGPAGDALQPPAGERV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10405327,
FT ECO:0000303|PubMed:9334251"
FT /id="VSP_023229"
FT VAR_SEQ 3057..3080
FT /note="MQKIFADMQGFTFKGVEILSLRNG -> EWQHRGGLPGPAGDALQPPAGERV
FT (in isoform 3)"
FT /evidence="ECO:0000305|PubMed:10512748"
FT /id="VSP_023230"
FT VAR_SEQ 3064..3323
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10405327,
FT ECO:0000303|PubMed:9334251"
FT /id="VSP_023231"
FT VAR_SEQ 3078..3081
FT /note="RNGS -> SPVF (in isoform 4)"
FT /evidence="ECO:0000305|PubMed:10512748"
FT /id="VSP_023232"
FT VAR_SEQ 3081..3323
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305|PubMed:10512748"
FT /id="VSP_023233"
FT VAR_SEQ 3082..3323
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000305|PubMed:10512748"
FT /id="VSP_023234"
FT VAR_SEQ 3204..3261
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:10405327"
FT /id="VSP_023235"
FT VARIANT 3120
FT /note="V -> A (in dbSNP:rs6960868)"
FT /evidence="ECO:0000269|PubMed:11289722"
FT /id="VAR_030722"
FT VARIANT 3299
FT /note="Y -> H (may be associated with Crohn disease;
FT dbSNP:rs10258821)"
FT /evidence="ECO:0000269|PubMed:11289722"
FT /id="VAR_030724"
FT VARIANT 3299
FT /note="Y -> N (in dbSNP:rs10258821)"
FT /evidence="ECO:0000269|PubMed:10512748,
FT ECO:0000269|PubMed:11289722"
FT /id="VAR_030723"
FT CONFLICT 258
FT /note="P -> S (in Ref. 1; AAQ73824)"
FT /evidence="ECO:0000305"
FT CONFLICT 337
FT /note="T -> P (in Ref. 1; AAQ73824)"
FT /evidence="ECO:0000305"
FT CONFLICT 1149
FT /note="L -> H (in Ref. 3; AAC02268)"
FT /evidence="ECO:0000305"
FT CONFLICT 1234
FT /note="T -> K (in Ref. 3; AAC02268)"
FT /evidence="ECO:0000305"
FT CONFLICT 1542
FT /note="P -> L (in Ref. 3; AAC02271)"
FT /evidence="ECO:0000305"
FT CONFLICT 1570
FT /note="G -> D (in Ref. 3; AAC02271)"
FT /evidence="ECO:0000305"
FT CONFLICT 1587
FT /note="S -> T (in Ref. 3; AAC02271)"
FT /evidence="ECO:0000305"
FT CONFLICT 1640
FT /note="P -> S (in Ref. 3; AAC02271)"
FT /evidence="ECO:0000305"
FT CONFLICT 1966..1969
FT /note="ETTS -> DSIV (in Ref. 3; AAC02271)"
FT /evidence="ECO:0000305"
FT CONFLICT 2099
FT /note="T -> I (in Ref. 4; AAF13032 and 3; AAC02272)"
FT /evidence="ECO:0000305"
FT CONFLICT 2110
FT /note="F -> Y (in Ref. 3; AAC02272 and 4; AAF13032)"
FT /evidence="ECO:0000305"
FT CONFLICT 2112
FT /note="S -> T (in Ref. 3; AAC02272 and 4; AAF13032)"
FT /evidence="ECO:0000305"
FT CONFLICT 2117
FT /note="S -> T (in Ref. 3; AAC02272 and 4; AAF13032)"
FT /evidence="ECO:0000305"
FT CONFLICT 2119
FT /note="M -> T (in Ref. 3; AAC02272 and 4; AAF13032)"
FT /evidence="ECO:0000305"
FT CONFLICT 2127
FT /note="F -> Y (in Ref. 3; AAC02272 and 4; AAF13032)"
FT /evidence="ECO:0000305"
FT CONFLICT 2129
FT /note="S -> T (in Ref. 3; AAC02272 and 4; AAF13032)"
FT /evidence="ECO:0000305"
FT CONFLICT 2136..2138
FT /note="NAT -> TPS (in Ref. 3; AAC02272 and 4; AAF13032)"
FT /evidence="ECO:0000305"
FT CONFLICT 2143
FT /note="N -> S (in Ref. 3; AAC02272 and 4; AAF13032)"
FT /evidence="ECO:0000305"
FT CONFLICT 2164..2166
FT /note="LIT -> SIR (in Ref. 3; AAC02272 and 4; AAF13032)"
FT /evidence="ECO:0000305"
FT CONFLICT 2169..2178
FT /note="Missing (in Ref. 3; AAC02272 and 4; AAF13032)"
FT /evidence="ECO:0000305"
FT CONFLICT 2322
FT /note="H -> R (in Ref. 3; AAC02272 and 4; AAF13032)"
FT /evidence="ECO:0000305"
FT CONFLICT 2393
FT /note="T -> P (in Ref. 3; AAC02272)"
FT /evidence="ECO:0000305"
FT CONFLICT 2956
FT /note="G -> GC (in Ref. 5; BAB12116)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 3323 AA; 345127 MW; 8C6E21ADD26637EF CRC64;
MQLLGLLGLL WMLKASPWAT GTLSTATSIS QVPFPRAEAA SAVLSNSPHS RDLAGWPLGV
PQLASPAPGH RENAPMTLTT SPHDTLISET LLNSPVSSNT STTPTSKFAF KVETTPPTVL
VYSATTECVY PTSFIITISH PTSICVTTTQ VAFTSSYTST PVTQKPVTTV TSTYSMTTTE
KGTSAMTSSP STTTARETPI VTVTPSSVSA TDTTFHTTIS STTRTTERTP LPTGSIHTTT
SPTPVFTTLK TAVTSTSPIT SSITSTNTVT SMTTTASQPT ATNTLSSPTR TILSSTPVLS
TETITSGITN TTPLSTLVTT LPTTISRSTP TSETTYTTSP TSTVTDSTTK IAYSTSMTGT
LSTETSLPPT SSSLPTTETA TTPMTNLVTT TTEISSHSTP SFSSSTIYST VSTSTTAISS
LPPTSGTMVT STTMTPSSLS TDIPFTTPTT ITHHSVGSTG FLTTATDLTS TFTVSSSSAM
STSVIPSSPS IQNTETSSLV SMTSATTPNV RPTFVSTLST PTSSLLTTFP ATYSFSSSMS
ASSAGTTHTE SISSPPASTS TLHTTAESTL APTTTTSFTT STTMEPPSTT AATTGTGQTT
FTSSTATFPE TTTPTPTTDM STESLTTAMT SPPITSSVTS TNTVTSMTTT TSPPTTTNSF
TSLTSMPLSS TPVPSTEVVT SGTINTIPPS ILVTTLPTPN ASSMTTSETT YPNSPTGPGT
NSTTEITYPT TMTETSSTAT SLPPTSPLVS TAKTAKTPTT NLVTTTTKTT SHSTTSFTSS
TVYSTASTYT TAITSVPTTL GTMVTSTSMI SSTVSTGIPT SQPTTITPSS VGISGSLPMM
TDLTSVYTVS NMSARPTTVI PSSPTVQNTE ISISVSMTSA TTPSGGPTFT STENTPTRSL
LTSFPMTHSF SSSMSESSAG TTHTESISSP RGTTSTLHTT VESTPSPTTT TSFTTSTMME
PPSSTVSTTG RGQTTFPSST ATFPETTTLT PTTDISTVSL TTAMTSPPPV SSSITPTNTM
TSMRTTTYWP TATNTLSPLT SSILSSTPVP STEMITSHTT NTTPLSTLVT TLLTTITRST
PTSETTYPTS PTSIVSDSTT EITYSTSITG TLSTATTLPP TSSSLPTTET ATMTPTTTLI
TTTPNTTSLS TPSFTSSTIY STVSTSTTAI SSASPTSGTM VTSTTMTPSS LSTDTPSTTP
TTITYPSVGS TGFLTTATDL TSTFTVSSSS AMSTSVIPSS PSIQNTETSS LVSMTSATTP
SLRPTITSTD STLTSSLLTT FPSTYSFSSS MSASSAGTTH TETISSLPAS TNTIHTTAES
ALAPTTTTSF TTSPTMEPPS TTVATTGTGQ TTFPSSTATF LETTTLTPTT DFSTESLTTA
MTSTPPITSS ITPTDTMTSM RTTTSWPTAT NTLSPLTSSI LSSTPVPSTE VTTSHTTNTN
PVSTLVTTLP ITITRSTLTS ETAYPSSPTS TVTESTTEIT YPTTMTETSS TATSLPPTSS
LVSTAETAKT PTTNLVTTTT KTTSHSTTSF TSSTIYSTAS TPTTAITSVP TTLGTMVTST
SMIPSTVSTG IPTSQPTTIT PSSVGISGSL PMMTDLTSVY TVSSMSARPT SVIPSSPTVQ
NTETSIFVSM MSATTPSGGP TFTSTENTPT RSLLTSFPVT HSFSSSMSAS SVGTTHTQSI
SSPPAITSTL HTTAESTPSP TTTMSFTTFT KMETPSSTVA TTGTGQTTFT SSTATSPKTT
TLTPTSDIST GSFKTAVSST PPITSSITST YTVTSMTTTT PLGPTATNTL PSFTSSVSSS
TPVPSTEAIT SGTTNTTPLS TLVTTFSNSD TSSTPTSETT YPTSLTSALT DSTTRTTYST
NMTGTLSTVT SLRPTSSSLL TTVTATVPTT NLVTTTTKIT SHSTPSFTSS IATTETPSHS
TPRFTSSITT TETPSHSTPR FTSSITNTKT TSHSSPSFTS SITTTETTSH NTPSLTSSIT
TTKTTSHSTP SYTSLITTTT TTSHSTPSFT SSITTTETTS HNTPSLTSSI TTTETTSHST
PSFTSSITTE TTSHSTPSFT SLITITEITS HSTLSYTTSI TTTETPSHST LSFTSSITTT
ETTSHSTPSF TSSITTSEMP SHSTPSFTSS ITTTENATHS TPNFTSSITT TETTSHSTPS
FTSLITTTET TSHRWGTTET TSYSTPSFTS SNTITETTSH STPSYITSIT TTETPSSSTP
SFSSSITTTE TTSHSTPGFT SSITTTETTS HSTPSFTSSI TTTETTSHDT PSFTSSITTS
ETPSHSTPSS TSLITTTKTT SHSTPSFTSS ITTTETTSHS AHSFTSSITT TETTSHNTRS
FTSSITTTET NSHSTTSFTS SITTTETTSH STPSFSSSIT TTETPLHSTP GLTSWVTTTK
TTSHITPGLT SSITTTETTS HSTPGFTSSI TTTETTSEST PSLSSSTIYS TVSTSTTAIT
SHFTTSETAV TPTPVTPSSL STDIPTTSLR TLTPSSVGTS TSLTTTTDFP SIPTDISTLP
TRTHIISSSP SIQSTETSSL VGTTSPTMST VRMTLRITEN TPISSFSTSI VVIPETPTQT
PPVLTSATGT QTSPAPTTVT FGSTDSSTST LHTLTPSTAL STIVSTSQVP IPSTHSSTLQ
TTPSTPSLQT SLTSTSEFTT ESFTRGSTST NAILTSFSTI IWSSTPTIIM SSSPSSASIT
PVFSTTIHSV PSSPYIFSTE NVGSASITGF PSLSSSATTS TSSTSSSLTT ALTEITPFSY
ISLPSTTPCP GTITITIVPA SPTDPCVEMD PSTEATSPPT TPLTVFPFTT EMVTCPTSIS
IQTTLTTYMD TSSMMPESES SISPNASSST GTGTVPTNTV FTSTRLPTSE TWLSNSSVIP
LPLPGVSTIP LTMKPSSSLP TILRTSSKST HPSPPTTRTS ETPVATTQTP TTLTSRRTTR
ITSQMTTQST LTTTAGTCDN GGTWEQGQCA CLPGFSGDRC QLQTRCQNGG QWDGLKCQCP
STFYGSSCEF AVEQVDLDVV ETEVGMEVSV DQQFSPDLND NTSQAYRDFN KTFWNQMQKI
FADMQGFTFK GVEILSLRNG SIVVDYLVLL EMPFSPQLES EYEQVKTTLK EGLQNASQDV
NSCQDSQTLC FKPDSIKVNN NSKTELTPAA ICRRAAPTGY EEFYFPLVEA TRLRCVTKCT
SGVDNAIDCH QGQCVLETSG PTCRCYSTDT HWFSGPRCEV AVHWRALVGG LTAGAALLVL
LLLALGVRAV RSGWWGGQRR GRSWDQDRKW FETWDEEVVG TFSNWGFEDD GTDKDTNFYV
ALENVDTTMK VHIKRPEMTS SSV
