MUC4_MOUSE
ID MUC4_MOUSE Reviewed; 3470 AA.
AC Q8JZM8; Q4VAA3; Q9ERB8; Q9QXG0; Q9WV36;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 29-SEP-2021, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Mucin-4;
DE Short=MUC-4;
DE AltName: Full=Ascites sialoglycoprotein;
DE Short=ASGP;
DE AltName: Full=Pancreatic adenocarcinoma mucin;
DE AltName: Full=Testis mucin;
DE Contains:
DE RecName: Full=Mucin-4 alpha chain;
DE AltName: Full=Ascites sialoglycoprotein 1;
DE Short=ASGP-1;
DE Contains:
DE RecName: Full=Mucin-4 beta chain;
DE AltName: Full=Ascites sialoglycoprotein 2;
DE Short=ASGP-2;
DE Flags: Precursor;
GN Name=Muc4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=129/SvJ;
RX PubMed=12084055; DOI=10.1046/j.1432-1033.2002.02988.x;
RA Desseyn J.-L., Clavereau I., Laine A.;
RT "Cloning, chromosomal localization and characterization of the murine mucin
RT gene orthologous to human MUC4.";
RL Eur. J. Biochem. 269:3150-3159(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-231.
RC STRAIN=CD-1;
RA Bartman A.E., Shekels L.L., Anway R.E., Gipson I.K., Moccia R., Ho S.B.;
RT "Identification and structure of a mouse homolog to the human MUC4 gene.";
RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3103-3470.
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 3208-3378.
RX PubMed=12107190; DOI=10.1074/jbc.m206395200;
RA Lee C.G., Homer R.J., Cohn L., Link H., Jung S., Craft J.E., Graham B.S.,
RA Johnson T.R., Elias J.A.;
RT "Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus
RT metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent
RT and -independent pathways.";
RL J. Biol. Chem. 277:35466-35474(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 3370-3470.
RC STRAIN=CF-1; TISSUE=Uterine horn luminal epithelium;
RA DeSouza M.M., Carson D.D., Harris M.N., Julian J.;
RT "Cloning and expression analysis of mouse ascites sialoglycoprotein-2
RT (ASGP-2)/Mucin 4 (Muc4).";
RL Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Membrane-bound mucin, a family of highly glycosylated
CC proteins that constitute the major component of the mucus, the slimy
CC and viscous secretion covering epithelial surfaces. These glycoproteins
CC play important roles in the protection of the epithelium and are
CC implicated in epithelial renewal and differentiation. Regulates
CC cellular behavior through both anti-adhesive effects on cell-cell and
CC cell-extracellular matrix interactions and its ability to act as an
CC intramembrane ligand for ERBB2. Plays an important role in
CC proliferation and differentiation of epithelial cells by inducing
CC specific phosphorylation of ERBB2. In polarized epithelial cells,
CC segregates ERBB2 and other ERBB receptors and prevents ERBB2 from
CC acting as a coreceptor. The interaction with ERBB2 leads to enhanced
CC expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex
CC leads to down-regulation of CDKN1B, resulting in repression of
CC apoptosis and stimulation of proliferation. Its ability to promote
CC tumor growth may be mainly due to repression of apoptosis as opposed to
CC proliferation. {ECO:0000250|UniProtKB:Q99102}.
CC -!- SUBUNIT: A heterodimeric complex, composed of a mucin-4 alpha chain and
CC a cysteine-rich transmembrane mucin-4 beta chain. Mucin-4 beta chain
CC interacts with ERBB2 via the EGF-like domain 1. In nonpolarized cells,
CC associates with ERBB2 and ERBB3. {ECO:0000250|UniProtKB:Q63661}.
CC -!- SUBCELLULAR LOCATION: [Mucin-4 beta chain]: Cell membrane
CC {ECO:0000250|UniProtKB:Q99102}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:Q99102}. Note=Isoforms lacking the Cys-rich
CC region, EGF-like domains and transmembrane region are secreted.
CC Secretion occurs by splicing or proteolytic processing.
CC {ECO:0000250|UniProtKB:Q99102}.
CC -!- SUBCELLULAR LOCATION: [Mucin-4 alpha chain]: Cell membrane
CC {ECO:0000250|UniProtKB:Q99102}. Secreted
CC {ECO:0000250|UniProtKB:Q99102}. Note=Forms a complex with Mucin-4 beta
CC chain at the cell membrane. {ECO:0000250|UniProtKB:Q99102}.
CC -!- TISSUE SPECIFICITY: Expressed in trachea, duodenum and intestine. Lower
CC expression in stomach, salivary glands, liver, gallbladder, and kidney.
CC {ECO:0000269|PubMed:12084055}.
CC -!- DOMAIN: [Mucin-4 alpha chain]: Essentially composed of an array of
CC serine- and threonine-rich tandem repeats which is highly polymorphic,
CC the variable number of tandem repeats (VNTR) region.
CC {ECO:0000250|UniProtKB:Q99102}.
CC -!- PTM: Proteolytically cleaved into 2 chains, mucin-4 alpha chain and
CC mucin-4 beta chain. {ECO:0000250|UniProtKB:Q99102}.
CC -!- PTM: [Mucin-4 alpha chain]: Highly O-glycosylated.
CC {ECO:0000250|UniProtKB:Q99102}.
CC -!- PTM: [Mucin-4 beta chain]: Predominantly N-glycosylated.
CC {ECO:0000250|UniProtKB:Q99102}.
CC -!- POLYMORPHISM: The variable number of tandem repeats (VNTR) region, an
CC array of serine- and threonine-rich tandem repeats, is encoded by a
CC single exon (exon 2) which is highly polymorphic. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG02256.1; Type=Miscellaneous discrepancy; Note=The sequence differs significantly from the reference genome sequence for various reasons.; Evidence={ECO:0000305};
CC Sequence=AAH96477.1; Type=Miscellaneous discrepancy; Note=The sequence differs significantly from the reference genome sequence for various reasons.; Evidence={ECO:0000305};
CC Sequence=AAM66254.1; Type=Miscellaneous discrepancy; Note=The sequence differs significantly from the reference genome sequence for various reasons.; Evidence={ECO:0000305};
CC Sequence=AAM66746.1; Type=Miscellaneous discrepancy; Note=The sequence differs significantly from the reference genome sequence for various reasons.; Evidence={ECO:0000305};
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DR EMBL; AC139244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC161755; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF441786; AAM66254.1; ALT_SEQ; mRNA.
DR EMBL; AF520422; AAM66746.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AF520421; AAM66746.1; JOINED; Genomic_DNA.
DR EMBL; AY007202; AAG02256.1; ALT_SEQ; mRNA.
DR EMBL; BC096477; AAH96477.1; ALT_SEQ; mRNA.
DR EMBL; AF218819; AAF25480.1; -; mRNA.
DR EMBL; AF161256; AAD43349.1; -; mRNA.
DR RefSeq; NP_536705.3; NM_080457.3.
DR GlyGen; Q8JZM8; 54 sites.
DR MaxQB; Q8JZM8; -.
DR PeptideAtlas; Q8JZM8; -.
DR PRIDE; Q8JZM8; -.
DR ProteomicsDB; 286084; -.
DR GeneID; 140474; -.
DR KEGG; mmu:140474; -.
DR CTD; 4585; -.
DR MGI; MGI:2153525; Muc4.
DR InParanoid; Q8JZM8; -.
DR PhylomeDB; Q8JZM8; -.
DR Reactome; R-MMU-913709; O-linked glycosylation of mucins.
DR Reactome; R-MMU-977068; Termination of O-glycan biosynthesis.
DR ChiTaRS; Muc4; mouse.
DR PRO; PR:Q8JZM8; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8JZM8; protein.
DR GO; GO:0016324; C:apical plasma membrane; ISO:MGI.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031528; C:microvillus membrane; ISO:MGI.
DR GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR GO; GO:0005176; F:ErbB-2 class receptor binding; ISO:MGI.
DR GO; GO:0044877; F:protein-containing complex binding; ISO:MGI.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IMP:MGI.
DR GO; GO:0030277; P:maintenance of gastrointestinal epithelium; ISO:MGI.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISO:MGI.
DR GO; GO:0022408; P:negative regulation of cell-cell adhesion; ISO:MGI.
DR GO; GO:0001953; P:negative regulation of cell-matrix adhesion; ISO:MGI.
DR GO; GO:0002853; P:negative regulation of T cell mediated cytotoxicity directed against tumor cell target; ISO:MGI.
DR GO; GO:0010469; P:regulation of signaling receptor activity; ISO:MGI.
DR InterPro; IPR005533; AMOP_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR003886; NIDO_dom.
DR InterPro; IPR001846; VWF_type-D.
DR Pfam; PF06119; NIDO; 1.
DR Pfam; PF00094; VWD; 1.
DR SMART; SM00723; AMOP; 1.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00539; NIDO; 1.
DR SMART; SM00216; VWD; 1.
DR PROSITE; PS50856; AMOP; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS51220; NIDO; 1.
DR PROSITE; PS51233; VWFD; 1.
PE 2: Evidence at transcript level;
KW Cell adhesion; Cell membrane; Disulfide bond; EGF-like domain;
KW Glycoprotein; Membrane; Reference proteome; Repeat; Secreted; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..3470
FT /note="Mucin-4"
FT /id="PRO_0000274227"
FT CHAIN 29..2745
FT /note="Mucin-4 alpha chain"
FT /evidence="ECO:0000250|UniProtKB:Q99102"
FT /id="PRO_0000274228"
FT CHAIN 2746..3470
FT /note="Mucin-4 beta chain"
FT /evidence="ECO:0000250|UniProtKB:Q99102"
FT /id="PRO_0000274229"
FT TRANSMEM 3432..3452
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 2458..2613
FT /note="NIDO"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00570"
FT DOMAIN 2614..2726
FT /note="AMOP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00347"
FT DOMAIN 2738..2937
FT /note="VWFD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 3173..3212
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 3382..3421
FT /note="EGF-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REGION 32..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 43..2501
FT /note="Variable number of tandem repeats (VNTR)"
FT /evidence="ECO:0000250|UniProtKB:Q99102"
FT REGION 199..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 691..925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 938..1219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1232..1400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1413..1524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1537..1647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1660..1992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2037..2107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2139..2185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2205..2237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2262..2368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 2745..2746
FT /note="Cleavage"
FT /evidence="ECO:0000250|UniProtKB:Q99102"
FT CARBOHYD 42
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 44
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 65
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 68
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 87
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 91
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 96
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 97
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 98
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 99
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 100
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 103
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 104
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 106
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 117
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 130
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 131
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 132
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 145
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 146
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 150
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 151
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 152
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 155
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 188
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 236
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 241
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 278
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 286
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 297
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 311
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 357
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 370
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 371
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 372
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 385
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 423
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 465
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 494
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 513
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 517
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 542
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 545
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 550
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 551
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 584
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 585
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 586
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 587
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 588
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 592
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 594
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 599
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 605
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 618
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 619
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 620
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 633
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 634
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 639
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 640
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 655
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 674
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 702
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 708
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 709
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 710
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 711
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 716
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 718
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 743
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 744
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 757
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 758
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 798
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 826
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 832
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 833
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 834
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 839
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 840
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 842
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 846
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 853
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 875
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 901
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 902
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 922
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 950
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 952
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 956
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 957
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 958
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 959
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 963
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 964
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 966
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 990
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 991
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 992
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1005
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1006
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1011
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1012
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1015
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1024
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1025
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1026
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1027
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1029
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1038
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1046
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1072
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1091
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1125
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1126
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1127
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1128
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1132
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1133
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1135
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1140
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1174
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1198
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1207
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1215
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1243
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1245
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1249
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1250
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1251
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1252
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1256
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1257
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1259
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1263
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1270
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1283
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1284
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1285
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1298
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1299
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1304
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1305
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1318
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1319
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1339
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1341
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1342
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1355
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1356
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1365
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1368
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1372
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1375
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1376
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1377
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1379
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1396
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1426
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1430
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1431
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1440
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1451
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1453
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1464
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1465
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1466
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1471
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1479
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1480
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1499
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1512
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1520
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1554
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1555
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1557
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1562
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1588
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1589
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1590
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1604
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1609
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1627
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1635
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1636
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1644
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1672
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1674
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1678
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1679
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1680
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1681
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1685
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1686
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1688
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1699
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1714
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1721
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1770
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1838
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1839
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1840
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1854
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1873
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1874
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1888
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1889
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1891
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1896
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1930
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1931
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1932
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1933
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1937
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1938
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1940
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1964
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1965
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1966
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1980
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2022
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2056
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2057
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2090
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2091
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2092
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2105
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2106
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2148
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2182
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2225
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2264
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2352
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2354
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2359
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2360
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2755
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2773
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2801
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2827
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2844
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2853
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2888
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2909
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2916
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2932
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2958
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2985
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3003
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3014
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3054
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3079
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3102
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3109
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3157
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3174
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3240
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3247
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3353
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 3177..3188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 3182..3200
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 3202..3211
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 3385..3396
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 3390..3405
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 3407..3420
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT CONFLICT 3208
FT /note="D -> G (in Ref. 5; AAF25480)"
FT /evidence="ECO:0000305"
FT CONFLICT 3411
FT /note="T -> I (in Ref. 6; AAD43349)"
FT /evidence="ECO:0000305"
FT CONFLICT 3414
FT /note="S -> T (in Ref. 6; AAD43349)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 3470 AA; 368411 MW; E54B9CF74CCFA475 CRC64;
MRGPHWRVPW LCLSCLYSCL LLLPDALATT STQTPMSLSS STRTSQMSSQ ASTSSTSSDR
RTSKTEQTST RDTPSSITTV SQSHHTTSME TSKPQTTTTT EVTTSTPSAS SRDQIQTETS
SQRTISPDGT TTSHAPSISS SAPSTTHMLT TTSSTESTSV DSGHTTAITT QGLTPATAQV
SLTPSSQNMS TVSTPITSTL TQRQHTGSKQ TSSKSQVNIV TSTLSTSTSD STPAQTMSQV
TSSSDKRTKP STSGVSSTSL TTTEVLTQTS STDSAPGNTT LRITQNSTTH TTKVSTTSTP
QKLSPVSTLI NSSQKMSTLP QNQHTESMDT SRQPQTTTTI EVTTSTPSAS SLHQIQTETN
SPKTISPGET TTSHAPNMRS SPPKTSQILT TMPSTKSTSV DTKQTKAITT KVSTPDTTQV
SMTPSSQKLP THSTSTQELT SSYSQHIQSK GTSSKSQTTT NTKVNTSTPS ASSRDKIQTE
TSSQRTNSPG EKRTSHAPSM SSSAPSTTHM LSTTSSNQST SVDTGQTTSV TAQGSTPAIT
QTSLTPSSQN TSTVSTPITS THKLSTLSQS QHTGSKGTSS NPQTTTTTEV TTSTPSATTH
DQIQTETSSQ NTISPGETTT SYAPIMSSSA PSTTHMLSTT SSTQSTSVDT RHTTTLTNQG
STPATTQVSP SSQNMSTVSA PITSTQILST FPQSQHTGSK GTSSNPQTTT TPVVTTSNPS
ATSRDQIQTE TSSQRTISPG ETTTSYASIM SSSAPSTTHM LTTTSSTQST SVDTRHTIAV
RTQGSTPATT QVSPSSQNMS TVSTPITSTQ ILSTLPQSQH TGSKGTSSNP QTTTSPVVTT
STPSGTSGDQ IQTETSSQRT ISPGKTTTSH ALNINSSAPS TTHMLSTTSS TQSTSGDTRH
TTAGRTQGST PATTQVSPSS QNMSTVSAPI TSIQMLSTLP QSQHTESKST STNPQTTTTP
EVTTSNPSAT SHDQIETETS SQRTISPGET TTSYAPIMSS SAPSTTHMLS TTSSTQSTSV
DTRNTTTLTT QGSTPATTQV SPSSKNMSTV STPITSTHKL STLPQSQHTG SNGTSSSSST
PATHRSHLHP NMSTVSTPIT TTHKLSTLSQ SQHTGSKGTS SNPQTTTTPV MTTSTPSATT
HDQIQTETSS QRTISHGETT TSYAPIMSSS APSTTHMLST ASSTQITSVD TRHTTAITTQ
GSTPATTQVS PSSQNMSTVS APITSIQILS TLPQSQHTGS KGTSTNPQTT TTPEVTTSTP
SATSRDQIQT ETSSQRTISP GETTTSHAPI MSSSAPSTTH MLSTTSSTQS TSVDTRHTTA
GRTQGSTPAT TQVSPSSQNM TTTSHALMSS SAPSTTHMLS TTSSTQSTSV DTRHTTTVTT
QGSTPATTQV LPSSQNMSTV SAPITSTQIL STLPQSQHTG SKGTSTNPQT TTNAEVTTST
PSATSHDQIE TETSSQRTIS PGETTTSHAP NMSSSAPSTT HMLSSTSSTQ ITSVDTGHTS
AGRTQGSTPA TTQVSPSSQN MSTVSAPITS THILSTLPKS QHTGSKGTSS NPQTTITPVV
TTSTPSASSR DQIQTETSFQ RTISPGETTT SHAPSMSSSA PSSTHMLSTA SSTQITSVDT
RHTTAITTQG STPATTQVSP SSQNMSTVSA PITSIQMLST LPQSQHTESK STSTNPQTTT
TPRVTTSTPS ASSRDQIQTE TSSQRTISPG KTTTSHVPNM NSSAPSTTHI LSTTSSIQST
SGDTRHTTAV RTQGSTPATT QVSLAPSSQN MSTLSAPITS PQHFSTLPQN QHTGSMGTSS
NPQSTTIPEV TTSTLSASSR DQVQTETSSQ RTISPGETTT SHASSLSSSA PSSTHMLSTA
SSTEITSGDT RHTTAIVTQG STPATTQTTL TPSSQNMSTV STPITSTHKL SPLPQSQHTE
NMGTSSNPQT TTTPEVTTST PSATSYDQIQ TETSFQRTIS PGETTTSHAP SMSNSAPSST
HKLSTASSTE ITSVDTRHTI AITTQGSTLA TTQTSLTPSS QNMSTVSAPI TSSQILSTLR
QSQHTGSKGT SSNHQTTTTP VVTTSTSSAT SRDQIQTETS SLRTISPDGT TTSHASSMSS
SSPNTTHLLI TTSSTESTSV DTGYSTVITT HGSTLATTQV SLTPSSQNMS TVSMPSTSSQ
ELTSLPQRQH TGNMETSSQP QNITPTVVTT STLLSFSRGS TELQTMSWGT SSSGTINTLS
TPVRNTSPAS TSGILTSTLT TSGNTGYTGV TRSLGVITSR VTSTSLPGKS TVVHSTPAQP
LSAHSQSHQT YGTGTPSMSQ TSILPDMTSE KRVASSPGPT VTESFSHVSS SSGLTTKTDN
DRNTAVSATS STLTSPSPTT ASRSTVPLPS LLPDQGISLF PYGSEVGDQN LFARTVDFNS
PIFKILIGFP LGSSLRDSFY VTDNGQIIFP ESDYDVFSYP NPPQRGFTGR ERVAMVAPFW
ADADFSSSRG AIFYQEYVTF YNEHHQLIRE VETLINDFTS SWGYRAKWTL KVTWVNVPAY
TAQESFGTNT YQAILSTDGS RSYALFLYQN SGMRWDVTQE PYNRVLMGFS SGDGYFENSP
LTFRPAMEKY RPDRFLNSKL GIRGLQVYRL HREERPNYRL KCLQWLESQP QQPSWGWSSV
SCPCSWQQGQ RDFRFRPINP GWWDRQLCSF SSGRGGVCCS YGAWGEFREG WRMHSPWQFD
EEQEAQNWCC QWNDKPSFCV WYQLRRPRVS CAGYRPPRPA WTFGDPHITT LDNANFTFNG
LGDFLLVQAQ DRNSSFLLEG RTAQTGTAKA TNFIAFAAQY NTSSLKSPIT VQWFLEPSDK
IRVVYNNQTV AFNTRDTEVL PIFNTTGVLL TQNGSQVSAN FDGTVTISVI ARSNILHASS
SLSEEYRNHT EGLLGVWNDN PEDDFRMPNG STIPSNSSEE TLFYYGMTWH VNGTGLLGIR
ADPLPTKFTP IFLSQLLNQS ASGEDLASGC KGDRKCMFDI LATGNRTIGQ STNSILNEFQ
HMNDTLNQYP PSINCSSKIQ AYKGQTVTTE ITSNSKDATL SLSKKCSGFK LFENGSLQWT
PTSPEACTLE ILARDVRTNL SWVLQPKTVA CFCSKEEQCL YNETSKEGNS SLEVTSCKCD
GDTFGRLCER SKDPCDEPCF PNVNCIPGKG CEACPPNTTG DGRHCAALED SCPNRSCPMN
YCYNNGHCDI SEAPGCQPTC TCPPAFTDNR CFLAGNSFTP TISMELPLRT IVLSLREDEN
ASAADVNASV ANILENLDMR AFFSNSLVEL IRTSPGAQPS SKSIHHWKVT SHFKYRPRGP
LIHYLNNQLI GAVMEAFLLQ ARQERQKRSG EARKDVHFFP ISRADVQDQM ALNLSMLEEY
FTCDGYKGYH LVYSPQDGVT CVSPCSEGYC HNGGQCKHLP DGPQCSCASF TIYSSSGEHC
EHLSVKLGAF YGILFGTLGA LLLLGILAFM IFHFCGCSKN KFSYPLDSEL
