MUC5B_HUMAN
ID MUC5B_HUMAN Reviewed; 5762 AA.
AC Q9HC84; O00447; O00573; O14985; O15494; O95291; O95451; Q14881; Q7M4S5;
AC Q99552; Q9UE28;
DT 10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 3.
DT 03-AUG-2022, entry version 181.
DE RecName: Full=Mucin-5B;
DE Short=MUC-5B;
DE AltName: Full=Cervical mucin;
DE AltName: Full=High molecular weight salivary mucin MG1;
DE AltName: Full=Mucin-5 subtype B, tracheobronchial;
DE AltName: Full=Sublingual gland mucin;
DE Flags: Precursor;
GN Name=MUC5B; Synonyms=MUC5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-1593, INDUCTION, TISSUE SPECIFICITY,
RP AND VARIANT GLY-34.
RX PubMed=11713095; DOI=10.1165/ajrcmb.25.5.4298;
RA Chen Y., Zhao Y.H., Di Y.P., Wu R.;
RT "Characterization of human mucin 5B gene expression in airway epithelium
RT and the genomic clone of the amino-terminal and 5'-flanking region.";
RL Am. J. Respir. Cell Mol. Biol. 25:542-553(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-1324.
RX PubMed=9790959; DOI=10.1006/bbrc.1998.9469;
RA Offner G.D., Nunes D.P., Keates A.C., Afdhal N.H., Troxler R.F.;
RT "The amino-terminal sequence of MUC5B contains conserved multifunctional D
RT domains: implications for tissue-specific mucin functions.";
RL Biochem. Biophys. Res. Commun. 251:350-355(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 28-1323, AND VARIANT GLY-34.
RX PubMed=9804771; DOI=10.1074/jbc.273.46.30157;
RA Desseyn J.-L., Buisine M.P., Porchet N., Aubert J.-P., Laine A.;
RT "Genomic organization of the human mucin gene MUC5B: cDNA and genomic
RT sequences upstream of the large central exon.";
RL J. Biol. Chem. 273:30157-30164(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1325-4954, NUCLEOTIDE SEQUENCE [MRNA]
RP OF 4170-4791, AND VARIANTS SER-1805; LEU-1889; THR-2025; THR-2194;
RP PRO-2238; THR-2425; SER-3072; ALA-3284; PRO-3468; MET-3816; GLY-4404;
RP LEU-4440; PRO-4706; MET-4712; THR-4867 AND ALA-4882.
RC TISSUE=Placenta, and Tracheobronchial mucosa;
RX PubMed=9013550; DOI=10.1074/jbc.272.6.3168;
RA Desseyn J.-L., Guyonnet-Duperat V., Porchet N., Aubert J.-P., Laine A.;
RT "Human mucin gene MUC5B, the 10.7 kb large central exon encodes various
RT alternate subdomains resulting in a super-repeat. Structural evidence for a
RT 11p15.5 gene family.";
RL J. Biol. Chem. 272:3168-3178(1997).
RN [5]
RP PROTEIN SEQUENCE OF 2346-2358; 2903-2915; 3603-3615 AND 4160-4172.
RC TISSUE=Tracheobronchial mucosa;
RX PubMed=2656675; DOI=10.1016/s0021-9258(18)83168-4;
RA Rose M.C., Kaufman B., Martin B.M.;
RT "Proteolytic fragmentation and peptide mapping of human
RT carboxyamidomethylated tracheobronchial mucin.";
RL J. Biol. Chem. 264:8193-8199(1989).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 2301-3811, AND TISSUE SPECIFICITY.
RC TISSUE=Salivary gland;
RX PubMed=9147051; DOI=10.1093/glycob/7.3.413;
RA Nielsen P.A., Bennett E.P., Wandall H.H., Therkildsen M.H., Hannibal J.,
RA Clausen H.;
RT "Identification of a major human high molecular weight salivary mucin (MG1)
RT as tracheobronchial mucin MUC5B.";
RL Glycobiology 7:413-419(1997).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4780-5423, NUCLEOTIDE SEQUENCE [MRNA]
RP OF 5373-5762, AND TISSUE SPECIFICITY.
RC TISSUE=Gall bladder;
RX PubMed=9164870; DOI=10.1042/bj3240295;
RA Keates A.C., Nunes D.P., Afdhal N.H., Troxler R.F., Offner G.D.;
RT "Molecular cloning of a major human gall bladder mucin: complete C-terminal
RT sequence and genomic organization of MUC5B.";
RL Biochem. J. 324:295-303(1997).
RN [8]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 4868-5746, AND TISSUE SPECIFICITY.
RC TISSUE=Sublingual gland;
RX PubMed=8554565; DOI=10.1006/bbrc.1995.2884;
RA Troxler R.F., Offner G.D., Zhang F., Iontcheva I., Oppenheim F.G.;
RT "Molecular cloning of a novel high molecular weight mucin (MG1) from human
RT sublingual gland.";
RL Biochem. Biophys. Res. Commun. 217:1112-1119(1995).
RN [9]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4918-5762, AND VARIANT THR-5196.
RC TISSUE=Placenta;
RX PubMed=9201995; DOI=10.1074/jbc.272.27.16873;
RA Desseyn J.-L., Aubert J.-P., Porchet N., Laine A.;
RT "Genomic organization of the 3 region of the human MUC5B mucin.";
RL J. Biol. Chem. 272:16873-16883(1997).
RN [10]
RP STRUCTURE OF O-LINKED CARBOHYDRATES, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=11445551; DOI=10.1093/glycob/11.6.459;
RA Silverman H.S., Parry S., Sutton-Smith M., Burdick M.D., McDermott K.,
RA Reid C.J., Batra S.K., Morris H.R., Hollingsworth M.A., Dell A., Harris A.;
RT "In vivo glycosylation of mucin tandem repeats.";
RL Glycobiology 11:459-471(2001).
RN [11]
RP GLYCOSYLATION, AND MUTAGENESIS OF TRP-1790.
RX PubMed=14718370; DOI=10.1093/glycob/cwh041;
RA Perez-Vilar J., Randell S.H., Boucher R.C.;
RT "C-Mannosylation of MUC5AC and MUC5B Cys subdomains.";
RL Glycobiology 14:325-337(2004).
RN [12]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-145; ASN-254; ASN-1556;
RP ASN-4960; ASN-5017; ASN-5024; ASN-5046; ASN-5096; ASN-5111 AND ASN-5215.
RC TISSUE=Saliva;
RX PubMed=16740002; DOI=10.1021/pr050492k;
RA Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.;
RT "Identification of N-linked glycoproteins in human saliva by glycoprotein
RT capture and mass spectrometry.";
RL J. Proteome Res. 5:1493-1503(2006).
RN [13]
RP INVOLVEMENT IN ILD2.
RX PubMed=21506741; DOI=10.1056/nejmoa1013660;
RA Seibold M.A., Wise A.L., Speer M.C., Steele M.P., Brown K.K., Loyd J.E.,
RA Fingerlin T.E., Zhang W., Gudmundsson G., Groshong S.D., Evans C.M.,
RA Garantziotis S., Adler K.B., Dickey B.F., du Bois R.M., Yang I.V.,
RA Herron A., Kervitsky D., Talbert J.L., Markin C., Park J., Crews A.L.,
RA Slifer S.H., Auerbach S., Roy M.G., Lin J., Hennessy C.E., Schwarz M.I.,
RA Schwartz D.A.;
RT "A common MUC5B promoter polymorphism and pulmonary fibrosis.";
RL N. Engl. J. Med. 364:1503-1512(2011).
RN [14]
RP INVOLVEMENT IN ILD2.
RX PubMed=21506748; DOI=10.1056/nejmc1013504;
RA Zhang Y., Noth I., Garcia J.G., Kaminski N.;
RT "A variant in the promoter of MUC5B and idiopathic pulmonary fibrosis.";
RL N. Engl. J. Med. 364:1576-1577(2011).
CC -!- FUNCTION: Gel-forming mucin that is thought to contribute to the
CC lubricating and viscoelastic properties of whole saliva and cervical
CC mucus.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed on surface airway epithelia. Expressed
CC mainly in mucous cells of submucosal glands of airway tissues. Highly
CC expressed in the sublingual gland. Also found in submaxillary glands,
CC endocervix, gall bladder, and pancreas. {ECO:0000269|PubMed:11713095,
CC ECO:0000269|PubMed:8554565, ECO:0000269|PubMed:9147051,
CC ECO:0000269|PubMed:9164870}.
CC -!- INDUCTION: Regulated by all-trans-retinoic acid (ATRA) in a cell-type
CC specific manner. {ECO:0000269|PubMed:11713095}.
CC -!- DOMAIN: The cysteine residues in the Cys-rich subdomain repeats are not
CC involved in disulfide bonding.
CC -!- PTM: Highly glycosylated. C-, N- and O-glycosylated. C-mannosylated in
CC the Cys-rich subdomains probably on the first Trp residue of the WXXW
CC motif. Highly O-glycosylated in the Ser/Thr-rich tandem repeat (TR)
CC region. The repeat region is about 59% O-glycosylated with a high
CC abundance of NeuAc(2)Hex(1)HexNac1-ol. {ECO:0000269|PubMed:14718370,
CC ECO:0000269|PubMed:16740002}.
CC -!- DISEASE: Interstitial lung disease 2 (ILD2) [MIM:178500]: A form of
CC interstitial lung disease, a heterogeneous group of diseases affecting
CC the distal part of the lung and characterized by a progressive
CC remodeling of the alveolar interstitium. The disease spectrum ranges
CC from idiopathic interstitial pneumonia or pneumonitis to idiopathic
CC pulmonary fibrosis, that is associated with an increased risk of
CC developing lung cancer. Clinical features of interstitial lung disease
CC include dyspnea, clubbing of the fingers, and restrictive lung
CC capacity. ILD2 inheritance is autosomal dominant.
CC {ECO:0000269|PubMed:21506741, ECO:0000269|PubMed:21506748}.
CC Note=Disease susceptibility is associated with variants affecting the
CC gene represented in this entry. A common polymorphism in the promoter
CC of MUC5B is associated with familial interstitial pneumonia and
CC idiopathic pulmonary fibrosis, suggesting that dysregulated MUC5B
CC expression in the lung may be involved in the pathogenesis of pulmonary
CC fibrosis (PubMed:21506741). {ECO:0000269|PubMed:21506741}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA06167.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Mucin database;
CC URL="http://www.medkem.gu.se/mucinbiology/databases/";
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DR EMBL; AF107890; AAG33673.1; -; Genomic_DNA.
DR EMBL; AF086604; AAC67545.1; -; mRNA.
DR EMBL; AJ004862; CAA06167.1; ALT_INIT; Genomic_DNA.
DR EMBL; X74955; CAA52910.1; -; mRNA.
DR EMBL; Z72496; CAA96577.1; -; Genomic_DNA.
DR EMBL; U63836; AAB61398.1; -; mRNA.
DR EMBL; U78551; AAC51343.1; -; mRNA.
DR EMBL; AH006676; AAC51344.1; -; Genomic_DNA.
DR EMBL; U95031; AAB65151.1; -; mRNA.
DR EMBL; Y09788; CAA70926.1; -; Genomic_DNA.
DR CCDS; CCDS44515.2; -.
DR PIR; A33811; A33811.
DR PIR; T45025; T45025.
DR RefSeq; NP_002449.2; NM_002458.2.
DR SMR; Q9HC84; -.
DR BioGRID; 608337; 50.
DR IntAct; Q9HC84; 9.
DR STRING; 9606.ENSP00000436812; -.
DR MEROPS; I08.953; -.
DR GlyConnect; 1520; 15 N-Linked glycans (10 sites), 6 O-Linked glycans.
DR GlyConnect; 376; 10 O-Linked glycans.
DR GlyGen; Q9HC84; 39 sites, 14 N-linked glycans (9 sites), 27 O-linked glycans (1 site).
DR iPTMnet; Q9HC84; -.
DR PhosphoSitePlus; Q9HC84; -.
DR BioMuta; MUC5B; -.
DR DMDM; 308153579; -.
DR jPOST; Q9HC84; -.
DR MassIVE; Q9HC84; -.
DR MaxQB; Q9HC84; -.
DR PaxDb; Q9HC84; -.
DR PeptideAtlas; Q9HC84; -.
DR PRIDE; Q9HC84; -.
DR Antibodypedia; 1456; 341 antibodies from 33 providers.
DR DNASU; 727897; -.
DR Ensembl; ENST00000529681.5; ENSP00000436812.1; ENSG00000117983.17.
DR GeneID; 727897; -.
DR KEGG; hsa:727897; -.
DR MANE-Select; ENST00000529681.5; ENSP00000436812.1; NM_002458.3; NP_002449.2.
DR UCSC; uc001lta.4; human.
DR CTD; 727897; -.
DR DisGeNET; 727897; -.
DR GeneCards; MUC5B; -.
DR HGNC; HGNC:7516; MUC5B.
DR HPA; ENSG00000117983; Tissue enriched (salivary).
DR MalaCards; MUC5B; -.
DR MIM; 178500; phenotype.
DR MIM; 600770; gene.
DR neXtProt; NX_Q9HC84; -.
DR OpenTargets; ENSG00000117983; -.
DR Orphanet; 171700; Diffuse panbronchiolitis.
DR Orphanet; 2032; Idiopathic pulmonary fibrosis.
DR PharmGKB; PA31321; -.
DR VEuPathDB; HostDB:ENSG00000117983; -.
DR eggNOG; KOG1216; Eukaryota.
DR GeneTree; ENSGT00940000162219; -.
DR HOGENOM; CLU_000076_3_1_1; -.
DR InParanoid; Q9HC84; -.
DR OMA; STWILTE; -.
DR OrthoDB; 12226at2759; -.
DR TreeFam; TF300299; -.
DR PathwayCommons; Q9HC84; -.
DR Reactome; R-HSA-5083625; Defective GALNT3 causes HFTC.
DR Reactome; R-HSA-5083632; Defective C1GALT1C1 causes TNPS.
DR Reactome; R-HSA-5083636; Defective GALNT12 causes CRCS1.
DR Reactome; R-HSA-5621480; Dectin-2 family.
DR Reactome; R-HSA-913709; O-linked glycosylation of mucins.
DR Reactome; R-HSA-977068; Termination of O-glycan biosynthesis.
DR SignaLink; Q9HC84; -.
DR BioGRID-ORCS; 727897; 13 hits in 1067 CRISPR screens.
DR ChiTaRS; MUC5B; human.
DR GeneWiki; MUC5B; -.
DR GenomeRNAi; 727897; -.
DR Pharos; Q9HC84; Tbio.
DR PRO; PR:Q9HC84; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9HC84; protein.
DR Bgee; ENSG00000117983; Expressed in trachea and 120 other tissues.
DR ExpressionAtlas; Q9HC84; baseline and differential.
DR Genevisible; Q9HC84; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; HDA:UniProtKB.
DR GO; GO:0005796; C:Golgi lumen; TAS:Reactome.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR014853; Unchr_dom_Cys-rich.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR InterPro; IPR025155; WxxW_domain.
DR Pfam; PF08742; C8; 4.
DR Pfam; PF13330; Mucin2_WxxW; 7.
DR Pfam; PF01826; TIL; 2.
DR Pfam; PF00094; VWD; 4.
DR SMART; SM00832; C8; 4.
DR SMART; SM00041; CT; 1.
DR SMART; SM00214; VWC; 5.
DR SMART; SM00215; VWC_out; 3.
DR SMART; SM00216; VWD; 4.
DR SUPFAM; SSF57567; SSF57567; 4.
DR PROSITE; PS01185; CTCK_1; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS01208; VWFC_1; 2.
DR PROSITE; PS50184; VWFC_2; 2.
DR PROSITE; PS51233; VWFD; 4.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Glycoprotein;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..5762
FT /note="Mucin-5B"
FT /id="PRO_0000019283"
FT DOMAIN 75..245
FT /note="VWFD 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 329..385
FT /note="TIL 1"
FT DOMAIN 423..598
FT /note="VWFD 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 695..752
FT /note="TIL 2"
FT DOMAIN 805..855
FT /note="TIL 3"
FT DOMAIN 855..927
FT /note="VWFC 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 893..1062
FT /note="VWFD 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT REPEAT 1333..1432
FT /note="Cys-rich subdomain 1"
FT REPEAT 1503..1604
FT /note="Cys-rich subdomain 2"
FT REPEAT 1784..1885
FT /note="Cys-rich subdomain 3"
FT REPEAT 2313..2414
FT /note="Cys-rich subdomain 4"
FT REPEAT 2854..2886
FT /note="HAT 1"
FT REPEAT 2871..2971
FT /note="Cys-rich subdomain 5"
FT REPEAT 3554..3586
FT /note="HAT 2"
FT REPEAT 3571..3671
FT /note="Cys-rich subdomain 6"
FT REPEAT 4111..4143
FT /note="HAT 3"
FT REPEAT 4128..4228
FT /note="Cys-rich subdomain 7"
FT DOMAIN 5073..5261
FT /note="VWFD 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 5412..5484
FT /note="VWFC 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 5521..5587
FT /note="VWFC 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220"
FT DOMAIN 5653..5742
FT /note="CTCK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT REGION 27..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1333..4228
FT /note="7 X Cys-rich subdomain repeats"
FT REGION 1437..1462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1480..1502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1607..1783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1890..2199
FT /note="11 X approximate tandem repeats, Ser/Thr-rich"
FT REGION 1890..2019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2031..2100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2114..2211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2242..2302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2419..2756
FT /note="11 X approximate tandem repeats, Ser/Thr-rich"
FT REGION 2443..2462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2473..2522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2556..2861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2976..3456
FT /note="17 X approximate tandem repeats, Ser/Thr-rich"
FT REGION 3001..3049
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3256..3357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3371..3469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3481..3561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3676..4013
FT /note="11 X approximate tandem repeats, Ser/Thr-rich"
FT REGION 3699..3779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3813..3917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3956..4118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4233..4879
FT /note="23 X approximate tandem repeats, Ser/Thr-rich"
FT REGION 4259..4389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4428..4447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4458..4527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4541..4750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1442..1462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1611..1783
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4285..4389
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 145
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:16740002"
FT CARBOHYD 201
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 254
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:16740002"
FT CARBOHYD 401
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 515
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 805
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 929
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1276
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1292
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1340
FT /note="C-linked (Man) tryptophan"
FT /evidence="ECO:0000305"
FT CARBOHYD 1509
FT /note="C-linked (Man) tryptophan"
FT /evidence="ECO:0000305"
FT CARBOHYD 1556
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:16740002"
FT CARBOHYD 1774
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1790
FT /note="C-linked (Man) tryptophan"
FT /evidence="ECO:0000305"
FT CARBOHYD 2320
FT /note="C-linked (Man) tryptophan"
FT /evidence="ECO:0000305"
FT CARBOHYD 2749
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2877
FT /note="C-linked (Man) tryptophan"
FT /evidence="ECO:0000305"
FT CARBOHYD 3449
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3577
FT /note="C-linked (Man) tryptophan"
FT /evidence="ECO:0000305"
FT CARBOHYD 4006
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4134
FT /note="C-linked (Man) tryptophan"
FT /evidence="ECO:0000305"
FT CARBOHYD 4804
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4960
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:16740002"
FT CARBOHYD 5017
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:16740002"
FT CARBOHYD 5024
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:16740002"
FT CARBOHYD 5046
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:16740002"
FT CARBOHYD 5096
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:16740002"
FT CARBOHYD 5111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:16740002"
FT CARBOHYD 5215
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:16740002"
FT CARBOHYD 5486
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5526
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5565
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5566
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5602
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5612
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5663
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5677
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5721
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 77..207
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 99..244
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 425..562
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 447..597
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 469..477
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 895..1026
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 917..1061
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 926..1023
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 944..951
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 5075..5221
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 5097..5260
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 5121..5132
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 5653..5705
FT /evidence="ECO:0000250"
FT DISULFID 5672..5719
FT /evidence="ECO:0000250"
FT DISULFID 5681..5735
FT /evidence="ECO:0000250"
FT DISULFID 5685..5737
FT /evidence="ECO:0000250"
FT DISULFID ?..5741
FT /evidence="ECO:0000250"
FT VARIANT 34
FT /note="E -> G (in dbSNP:rs2672785)"
FT /evidence="ECO:0000269|PubMed:11713095,
FT ECO:0000269|PubMed:9804771"
FT /id="VAR_063616"
FT VARIANT 51
FT /note="R -> W (in dbSNP:rs2075853)"
FT /id="VAR_056588"
FT VARIANT 1360
FT /note="T -> M (in dbSNP:rs12363494)"
FT /id="VAR_059538"
FT VARIANT 1401
FT /note="R -> H (in dbSNP:rs10835639)"
FT /id="VAR_059539"
FT VARIANT 1805
FT /note="G -> S (in dbSNP:rs1541314)"
FT /evidence="ECO:0000269|PubMed:9013550"
FT /id="VAR_063617"
FT VARIANT 1889
FT /note="P -> L (in dbSNP:rs2943510)"
FT /evidence="ECO:0000269|PubMed:9013550"
FT /id="VAR_063618"
FT VARIANT 2025
FT /note="A -> T (in dbSNP:rs34739266)"
FT /evidence="ECO:0000269|PubMed:9013550"
FT /id="VAR_063619"
FT VARIANT 2027
FT /note="A -> T (in dbSNP:rs1554937069)"
FT /id="VAR_059540"
FT VARIANT 2194
FT /note="M -> T (in dbSNP:rs2943502)"
FT /evidence="ECO:0000269|PubMed:9013550"
FT /id="VAR_063620"
FT VARIANT 2238
FT /note="L -> P (in dbSNP:rs4963031)"
FT /evidence="ECO:0000269|PubMed:9013550"
FT /id="VAR_063621"
FT VARIANT 2425
FT /note="M -> T (in dbSNP:rs3965632)"
FT /evidence="ECO:0000269|PubMed:9013550"
FT /id="VAR_063622"
FT VARIANT 2559
FT /note="T -> M (in dbSNP:rs60787297)"
FT /id="VAR_059541"
FT VARIANT 3072
FT /note="F -> S (in dbSNP:rs55813014)"
FT /evidence="ECO:0000269|PubMed:9013550"
FT /id="VAR_063623"
FT VARIANT 3284
FT /note="T -> A (in dbSNP:rs2943531)"
FT /evidence="ECO:0000269|PubMed:9013550"
FT /id="VAR_063624"
FT VARIANT 3468
FT /note="R -> P (in dbSNP:rs2943529)"
FT /evidence="ECO:0000269|PubMed:9013550"
FT /id="VAR_063625"
FT VARIANT 3816
FT /note="T -> M (in dbSNP:rs201948297)"
FT /evidence="ECO:0000269|PubMed:9013550"
FT /id="VAR_063626"
FT VARIANT 4404
FT /note="A -> G (in dbSNP:rs2943517)"
FT /evidence="ECO:0000269|PubMed:9013550"
FT /id="VAR_063627"
FT VARIANT 4440
FT /note="P -> L (in dbSNP:rs2943516)"
FT /evidence="ECO:0000269|PubMed:9013550"
FT /id="VAR_063628"
FT VARIANT 4706
FT /note="T -> P (in dbSNP:rs2943512)"
FT /evidence="ECO:0000269|PubMed:9013550"
FT /id="VAR_063629"
FT VARIANT 4712
FT /note="T -> M (in dbSNP:rs2943511)"
FT /evidence="ECO:0000269|PubMed:9013550"
FT /id="VAR_063630"
FT VARIANT 4867
FT /note="A -> T (in dbSNP:rs3021155)"
FT /evidence="ECO:0000269|PubMed:9013550"
FT /id="VAR_063631"
FT VARIANT 4882
FT /note="T -> A (in dbSNP:rs3021156)"
FT /evidence="ECO:0000269|PubMed:9013550"
FT /id="VAR_063632"
FT VARIANT 5196
FT /note="S -> T (in dbSNP:rs2672788)"
FT /evidence="ECO:0000269|PubMed:9201995"
FT /id="VAR_014123"
FT MUTAGEN 1790
FT /note="W->A: Poorly secreted."
FT /evidence="ECO:0000269|PubMed:14718370"
FT CONFLICT 95..100
FT /note="FPGLCN -> LPCLCK (in Ref. 2; AAC67545)"
FT /evidence="ECO:0000305"
FT CONFLICT 104
FT /note="S -> C (in Ref. 2; AAC67545)"
FT /evidence="ECO:0000305"
FT CONFLICT 142
FT /note="E -> K (in Ref. 1; AAG33673)"
FT /evidence="ECO:0000305"
FT CONFLICT 225
FT /note="R -> S (in Ref. 2; AAC67545)"
FT /evidence="ECO:0000305"
FT CONFLICT 330..331
FT /note="PL -> T (in Ref. 2; AAC67545)"
FT /evidence="ECO:0000305"
FT CONFLICT 337
FT /note="E -> N (in Ref. 2; AAC67545)"
FT /evidence="ECO:0000305"
FT CONFLICT 356
FT /note="E -> K (in Ref. 2; AAC67545)"
FT /evidence="ECO:0000305"
FT CONFLICT 362
FT /note="G -> R (in Ref. 2; AAC67545)"
FT /evidence="ECO:0000305"
FT CONFLICT 368
FT /note="G -> GS (in Ref. 1; AAG33673)"
FT /evidence="ECO:0000305"
FT CONFLICT 373
FT /note="D -> N (in Ref. 2; AAC67545)"
FT /evidence="ECO:0000305"
FT CONFLICT 392..393
FT /note="RT -> TR (in Ref. 2; AAC67545)"
FT /evidence="ECO:0000305"
FT CONFLICT 467..468
FT /note="RK -> GR (in Ref. 2; AAC67545)"
FT /evidence="ECO:0000305"
FT CONFLICT 511
FT /note="L -> P (in Ref. 2; AAC67545)"
FT /evidence="ECO:0000305"
FT CONFLICT 584..586
FT /note="GAA -> AH (in Ref. 3; CAA06167)"
FT /evidence="ECO:0000305"
FT CONFLICT 600
FT /note="A -> S (in Ref. 3; CAA06167)"
FT /evidence="ECO:0000305"
FT CONFLICT 627..628
FT /note="DP -> RS (in Ref. 2; AAC67545)"
FT /evidence="ECO:0000305"
FT CONFLICT 632
FT /note="F -> L (in Ref. 2; AAC67545)"
FT /evidence="ECO:0000305"
FT CONFLICT 675
FT /note="A -> P (in Ref. 3; CAA06167)"
FT /evidence="ECO:0000305"
FT CONFLICT 700
FT /note="R -> P (in Ref. 3; CAA06167)"
FT /evidence="ECO:0000305"
FT CONFLICT 751
FT /note="E -> K (in Ref. 2; AAC67545)"
FT /evidence="ECO:0000305"
FT CONFLICT 811
FT /note="P -> L (in Ref. 2; AAC67545)"
FT /evidence="ECO:0000305"
FT CONFLICT 816..817
FT /note="LR -> DG (in Ref. 2; AAC67545)"
FT /evidence="ECO:0000305"
FT CONFLICT 859..860
FT /note="HN -> NK (in Ref. 2; AAC67545)"
FT /evidence="ECO:0000305"
FT CONFLICT 866
FT /note="P -> L (in Ref. 2; AAC67545)"
FT /evidence="ECO:0000305"
FT CONFLICT 872
FT /note="V -> F (in Ref. 2; AAC67545)"
FT /evidence="ECO:0000305"
FT CONFLICT 883
FT /note="R -> T (in Ref. 2; AAC67545)"
FT /evidence="ECO:0000305"
FT CONFLICT 889
FT /note="R -> G (in Ref. 3; CAA06167)"
FT /evidence="ECO:0000305"
FT CONFLICT 1020
FT /note="G -> A (in Ref. 2; AAC67545)"
FT /evidence="ECO:0000305"
FT CONFLICT 1082
FT /note="Q -> E (in Ref. 2; AAC67545)"
FT /evidence="ECO:0000305"
FT CONFLICT 1144
FT /note="S -> C (in Ref. 3; CAA06167)"
FT /evidence="ECO:0000305"
FT CONFLICT 1195
FT /note="G -> R (in Ref. 2; AAC67545)"
FT /evidence="ECO:0000305"
FT CONFLICT 1207
FT /note="Missing (in Ref. 2; AAC67545)"
FT /evidence="ECO:0000305"
FT CONFLICT 1291
FT /note="S -> T (in Ref. 3; CAA06167)"
FT /evidence="ECO:0000305"
FT CONFLICT 1317
FT /note="Missing (in Ref. 2; AAC67545)"
FT /evidence="ECO:0000305"
FT CONFLICT 1675..1677
FT /note="TTP -> RQS (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 1926..1927
FT /note="PT -> AS (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 1930..1931
FT /note="LR -> QA (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 1934..1940
FT /note="PPPKVLT -> GTPHVS (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 1956
FT /note="S -> F (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 1980..1982
FT /note="VTP -> FTA (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 2002
FT /note="T -> M (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 2017
FT /note="A -> V (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 2052
FT /note="P -> L (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 2069..2073
FT /note="TALTP -> RARTL (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 2102
FT /note="A -> P (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 2174
FT /note="N -> S (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 2203
FT /note="P -> S (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 2211
FT /note="R -> C (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 2233
FT /note="V -> G (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 2300
FT /note="S -> Q (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 2333
FT /note="P -> S (in Ref. 6; AAB61398)"
FT /evidence="ECO:0000305"
FT CONFLICT 2456..2497
FT /note="SSTPGTTWILTEPSTTATVTVPTGSTATASSTQATAGTPHVS -> TSTLRT
FT APPPKVLT (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 2461..2462
FT /note="TT -> DD (in Ref. 6; AAB61398)"
FT /evidence="ECO:0000305"
FT CONFLICT 2468..3695
FT /note="Missing (in Ref. 6; AAB61398)"
FT /evidence="ECO:0000305"
FT CONFLICT 2513
FT /note="F -> S (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 2537..2539
FT /note="FTA -> VTP (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 2574
FT /note="V -> A (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 2582
FT /note="T -> A (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 2609
FT /note="L -> P (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 2628..2630
FT /note="RTL -> LTP (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 2659
FT /note="P -> A (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 2713
FT /note="T -> R (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 2834
FT /note="R -> T (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 3028
FT /note="T -> Q (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 3080..3086
FT /note="LPEQTTT -> SQNRPPH (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 3148..3152
FT /note="TGPTA -> LPHG (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 3289
FT /note="Missing (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 3490
FT /note="V -> G (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 3500
FT /note="S -> G (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 3504
FT /note="H -> P (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 3716..3747
FT /note="PGTTWILTEPSTTATVTVPTGSTATASSTQAT -> QGPP (in Ref. 4;
FT CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 3811
FT /note="Q -> P (in Ref. 6; AAB61398)"
FT /evidence="ECO:0000305"
FT CONFLICT 3831
FT /note="A -> V (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 3845
FT /note="R -> G (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 3909
FT /note="V -> I (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 3924..3925
FT /note="TT -> QP (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 3975
FT /note="V -> E (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 4060..4061
FT /note="QH -> TT (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 4114
FT /note="S -> Q (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 4177
FT /note="Q -> T (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 4313
FT /note="S -> T (in Ref. 4; CAA52910)"
FT /evidence="ECO:0000305"
FT CONFLICT 4373
FT /note="Missing (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 4461..4463
FT /note="VPT -> APP (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 4567
FT /note="A -> T (in Ref. 4; CAA96577)"
FT /evidence="ECO:0000305"
FT CONFLICT 4780
FT /note="T -> P (in Ref. 7; AAC51344)"
FT /evidence="ECO:0000305"
FT CONFLICT 5134
FT /note="R -> A (in Ref. 8; AAB65151)"
FT /evidence="ECO:0000305"
FT CONFLICT 5164
FT /note="Q -> P (in Ref. 8; AAB65151)"
FT /evidence="ECO:0000305"
FT CONFLICT 5187
FT /note="R -> A (in Ref. 7; AAC51344 and 8; AAB65151)"
FT /evidence="ECO:0000305"
FT CONFLICT 5289
FT /note="P -> L (in Ref. 8; AAB65151)"
FT /evidence="ECO:0000305"
FT CONFLICT 5304..5306
FT /note="NLV -> TLL (in Ref. 8; AAB65151)"
FT /evidence="ECO:0000305"
FT CONFLICT 5333
FT /note="A -> R (in Ref. 7; AAC51344)"
FT /evidence="ECO:0000305"
FT CONFLICT 5397
FT /note="D -> N (in Ref. 7; AAC51343/AAC51344)"
FT /evidence="ECO:0000305"
FT CONFLICT 5474
FT /note="E -> R (in Ref. 9; CAA70926)"
FT /evidence="ECO:0000305"
FT CONFLICT 5475
FT /note="N -> T (in Ref. 8; AAB65151)"
FT /evidence="ECO:0000305"
FT CONFLICT 5620
FT /note="A -> S (in Ref. 8; AAB65151)"
FT /evidence="ECO:0000305"
FT CONFLICT 5632
FT /note="A -> D (in Ref. 7; AAC51343)"
FT /evidence="ECO:0000305"
FT CONFLICT 5660
FT /note="V -> C (in Ref. 8; AAB65151)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 5762 AA; 596340 MW; 1FEC7CDCD0ADA81C CRC64;
MGAPSACRTL VLALAAMLVV PQAETQGPVE PSWENAGHTM DGGAPTSSPT RRVSFVPPVT
VFPSLSPLNP AHNGRVCSTW GDFHYKTFDG DVFRFPGLCN YVFSEHCRAA YEDFNVQLRR
GLVGSRPVVT RVVIKAQGLV LEASNGSVLI NGQREELPYS RTGLLVEQSG DYIKVSIRLV
LTFLWNGEDS ALLELDPKYA NQTCGLCGDF NGLPAFNEFY AHNARLTPLQ FGNLQKLDGP
TEQCPDPLPL PAGNCTDEEG ICHRTLLGPA FAECHALVDS TAYLAACAQD LCRCPTCPCA
TFVEYSRQCA HAGGQPRNWR CPELCPRTCP LNMQHQECGS PCTDTCSNPQ RAQLCEDHCV
DGCFCPPGTV LDDITHSGCL PLGQCPCTHG GRTYSPGTSF NTTCSSCTCS GGLWQCQDLP
CPGTCSVQGG AHISTYDEKL YDLHGDCSYV LSKKCADSSF TVLAELRKCG LTDNENCLKA
VTLSLDGGDT AIRVQADGGV FLNSIYTQLP LSAANITLFT PSSFFIVVQT GLGLQLLVQL
VPLMQVFVRL DPAHQGQMCG LCGNFNQNQA DDFTALSGVV EATGAAFANT WKAQAACANA
RNSFEDPCSL SVENENYARH WCSRLTDPNS AFSRCHSIIN PKPFHSNCMF DTCNCERSED
CLCAALSSYV HACAAKGVQL SDWRDGVCTK YMQNCPKSQR YAYVVDACQP TCRGLSEADV
TCSVSFVPVD GCTCPAGTFL NDAGACVPAQ ECPCYAHGTV LAPGEVVHDE GAVCSCTGGK
LSCLGASLQK STGCAAPMVY LDCSNSSAGT PGAECLRSCH TLDVGCFSTH CVSGCVCPPG
LVSDGSGGCI AEEDCPCVHN EATYKPGETI RVDCNTCTCR NRRWECSHRL CLGTCVAYGD
GHFITFDGDR YSFEGSCEYI LAQDYCGDNT THGTFRIVTE NIPCGTTGTT CSKAIKLFVE
SYELILQEGT FKAVARGPGG DPPYKIRYMG IFLVIETHGM AVSWDRKTSV FIRLHQDYKG
RVCGLCGNFD DNAINDFATR SRSVVGDALE FGNSWKLSPS CPDALAPKDP CTANPFRKSW
AQKQCSILHG PTFAACRSQV DSTKYYEACV NDACACDSGG DCECFCTAVA AYAQACHDAG
LCVSWRTPDT CPLFCDFYNP HGGCEWHYQP CGAPCLKTCR NPSGHCLVDL PGLEGCYPKC
PPSQPFFNED QMKCVAQCGC YDKDGNYYDV GARVPTAENC QSCNCTPSGI QCAHSLEACT
CTYEDRTYSY QDVIYNTTDG LGACLIAICG SNGTIIRKAV ACPGTPATTP FTFTTAWVPH
STTSPALPVS TVCVREVCRW SSWYNGHRPE PGLGGGDFET FENLRQRGYQ VCPVLADIEC
RAAQLPDMPL EELGQQVDCD RMRGLMCANS QQSPPLCHDY ELRVLCCEYV PCGPSPAPGT
SPQPSLSAST EPAVPTPTQT TATEKTTLWV TPSIRSTAAL TSQTGSSSGP VTVTPSAPGT
TTCQPRCQWT EWFDEDYPKS EQLGGDVESY DKIRAAGGHL CQQPKDIECQ AESFPNWTLA
QVGQKVHCDV HFGLVCRNWE QEGVFKMCYN YRIRVLCCSD DHCRGRATTP PPTTELETAT
TTTTQALFST PQPTSSPGLT RAPPASTTAV PTLSEGLTSP RYTSTLGTAT TGGPTTPAGS
TEPTVPGVAT STLPTRSALP GTTGSLGTWR PSQPPTLAPT TMATSRARPT GTASTASKEP
LTTSLAPTLT SELSTSQAET STPRTETTMS PLTNTTTSQG TTRCQPKCEW TEWFDVDFPT
SGVAGGDMET FENIRAAGGK MCWAPKSIEC RAENYPEVSI DQVGQVLTCS LETGLTCKNE
DQTGRFNMCF NYNVRVLCCD DYSHCPSTPA TSSTATPSST PGTTWILTKP TTTATTTAST
GSTATPTSTL RTAPPPKVLT TTATTPTVTS SKATPSSSPG TATALPALRS TATTPTATSV
TPIPSSSLGT TWTRLSQTTT PTATMSTATP SSTPETAHTS TVLTATATTT GATGSVATPS
STPGTAHTTK VPTTTTTGFT ATPSSSPGTA LTPPVWISTT TTPTTRGSTV TPSSIPGTTH
TATVLTTTTT TVATGSMATP SSSTQTSGTP PSLTTTATTI TATGSTTNPS STPGTTPIPP
VLTTTATTPA ATSNTVTPSS ALGTTHTPPV PNTMATTHGR SLPPSSPHTV RTAWTSATSG
ILGTTHITEP STVTSHTLAA TTGTTQHSTP ALSSPHPSSR TTESPPSPGT TTPGHTTATS
RTTATATPSK TRTSTLLPSS PTSAPITTVV TMGCEPQCAW SEWLDYSYPM PGPSGGDFDT
YSNIRAAGGA VCEQPLGLEC RAQAQPGVPL RELGQVVECS LDFGLVCRNR EQVGKFKMCF
NYEIRVFCCN YGHCPSTPAT SSTAMPSSTP GTTWILTELT TTATTTESTG STATPSSTPG
TTWILTEPST TATVTVPTGS TATASSTQAT AGTPHVSTTA TTPTVTSSKA TPFSSPGTAT
ALPALRSTAT TPTATSFTAI PSSSLGTTWT RLSQTTTPTA TMSTATPSST PETVHTSTVL
TTTATTTGAT GSVATPSSTP GTAHTTKVLT TTTTGFTATP SSSPGTARTL PVWISTTTTP
TTRGSTVTPS SIPGTTHTPT VLTTTTTTVA TGSMATPSSS TQTSGTPPSL TTTATTITAT
GSTTNPSSTP GTTPIPPVLT TTATTPAATS STVTPSSALG TTHTPPVPNT TATTHGRSLS
PSSPHTVRTA WTSATSGTLG TTHITEPSTG TSHTPAATTG TTQHSTPALS SPHPSSRTTE
SPPSPGTTTP GHTRATSRTT ATATPSKTRT STLLPSSPTS APITTVVTMG CEPQCAWSEW
LDYSYPMPGP SGGDFDTYSN IRAAGGAVCE QPLGLECRAQ AQPGVPLREL GQVVECSLDF
GLVCRNREQV GKFKMCFNYE IRVFCCNYGH CPSTPATSST ATPSSTPGTT WILTEQTTAA
TTTATTGSTA IPSSTPGTAP PPKVLTSTAT TPTATSSKAT SSSSPRTATT LPVLTSTATK
STATSFTPIP SFTLGTTGTL PEQTTTPMAT MSTIHPSSTP ETTHTSTVLT TKATTTRATS
SMSTPSSTPG TTWILTELTT AATTTAATGP TATPSSTPGT TWILTEPSTT ATVTVPTGST
ATASSTRATA GTLKVLTSTA TTPTVISSRA TPSSSPGTAT ALPALRSTAT TPTATSVTAI
PSSSLGTAWT RLSQTTTPTA TMSTATPSST PETVHTSTVL TTTTTTTRAT GSVATPSSTP
GTAHTTKVPT TTTTGFTATP SSSPGTALTP PVWISTTTTP TTRGSTVTPS SIPGTTHTAT
VLTTTTTTVA TGSMATPSSS TQTSGTPPSL TTTATTITAT GSTTNPSSTP GTTPIPPVLT
TTATTPAATS STVTPSSALG TTHTPPVPNT TATTHGRSLP PSSPHTVRTA WTSATSGILG
TTHITEPSTV TSHTPAATTS TTQHSTPALS SPHPSSRTTE SPPSPGTTTP GHTRGTSRTT
ATATPSKTRT STLLPSSPTS APITTVVTTG CEPQCAWSEW LDYSYPMPGP SGGDFDTYSN
IRAAGGAVCE QPLGLECRAQ AQPGVPLREL GQVVECSLDF GLVCRNREQV GKFKMCFNYE
IRVFCCNYGH CPSTPATSST ATPSSTPGTT WILTKLTTTA TTTESTGSTA TPSSTPGTTW
ILTEPSTTAT VTVPTGSTAT ASSTQATAGT PHVSTTATTP TVTSSKATPF SSPGTATALP
ALRSTATTPT ATSFTAIPSS SLGTTWTRLS QTTTPTATMS TATPSSTPET AHTSTVLTTT
ATTTRATGSV ATPSSTPGTA HTTKVPTTTT TGFTVTPSSS PGTARTPPVW ISTTTTPTTS
GSTVTPSSVP GTTHTPTVLT TTTTTVATGS MATPSSSTQT SGTPPSLITT ATTITATGST
TNPSSTPGTT PIPPVLTTTA TTPAATSSTV TPSSALGTTH TPPVPNTTAT THGRSLSPSS
PHTVRTAWTS ATSGTLGTTH ITEPSTGTSH TPAATTGTTQ HSTPALSSPH PSSRTTESPP
SPGTTTPGHT TATSRTTATA TPSKTRTSTL LPSSPTSAPI TTVVTTGCEP QCAWSEWLDY
SYPMPGPSGG DFDTYSNIRA AGGAVCEQPL GLECRAQAQP GVPLGELGQV VECSLDFGLV
CRNREQVGKF KMCFNYEIRV FCCNYGHCPS TPATSSTAMP SSTPGTTWIL TELTTTATTT
ASTGSTATPS STPGTAPPPK VLTSPATTPT ATSSKATSSS SPRTATTLPV LTSTATKSTA
TSVTPIPSST LGTTGTLPEQ TTTPVATMST IHPSSTPETT HTSTVLTTKA TTTRATSSTS
TPSSTPGTTW ILTELTTAAT TTAATGPTAT PSSTPGTTWI LTELTTTATT TASTGSTATP
SSTPGTTWIL TEPSTTATVT VPTGSTATAS STQATAGTPH VSTTATTPTV TSSKATPSSS
PGTATALPAL RSTATTPTAT SFTAIPSSSL GTTWTRLSQT TTPTATMSTA TPSSTPETVH
TSTVLTATAT TTGATGSVAT PSSTPGTAHT TKVPTTTTTG FTATPSSSPG TALTPPVWIS
TTTTPTTTTP TTSGSTVTPS SIPGTTHTAR VLTTTTTTVA TGSMATPSSS TQTSGTPPSL
TTTATTITAT GSTTNPSSTP GTTPITPVLT STATTPAATS SKATSSSSPR TATTLPVLTS
TATKSTATSF TPIPSSTLWT TWTVPAQTTT PMSTMSTIHT SSTPETTHTS TVLTTTATMT
RATNSTATPS STLGTTRILT ELTTTATTTA ATGSTATLSS TPGTTWILTE PSTIATVMVP
TGSTATASST LGTAHTPKVV TTMATMPTAT ASTVPSSSTV GTTRTPAVLP SSLPTFSVST
VSSSVLTTLR PTGFPSSHFS TPCFCRAFGQ FFSPGEVIYN KTDRAGCHFY AVCNQHCDID
RFQGACPTSP PPVSSAPLSS PSPAPGCDNA IPLRQVNETW TLENCTVARC VGDNRVVLLD
PKPVANVTCV NKHLPIKVSD PSQPCDFHYE CECICSMWGG SHYSTFDGTS YTFRGNCTYV
LMREIHARFG NLSLYLDNHY CTASATAAAA RCPRALSIHY KSMDIVLTVT MVHGKEEGLI
LFDQIPVSSG FSKNGVLVSV LGTTTMRVDI PALGVSVTFN GQVFQARLPY SLFHNNTEGQ
CGTCTNNQRD DCLQRDGTTA ASCKDMAKTW LVPDSRKDGC WAPTGTPPTA SPAAPVSSTP
TPTPCPPQPL CDLMLSQVFA ECHNLVPPGP FFNACISDHC RGRLEVPCQS LEAYAELCRA
RGVCSDWRGA TGGLCDLTCP PTKVYKPCGP IQPATCNSRN QSPQLEGMAE GCFCPEDQIL
FNAHMGICVQ ACPCVGPDGF PKFPGERWVS NCQSCVCDEG SVSVQCKPLP CDAQGQPPPC
NRPGFVTVTR PRAENPCCPE TVCVCNTTTC PQSLPVCPPG QESICTQEEG DCCPTFRCRP
QLCSYNGTFY GVGATFPGAL PCHMCTCLSG DTQDPTVQCQ EDACNNTTCP QGFEYKRVAG
QCCGECVQTA CLTPDGQPVQ LNETWVNSHV DNCTVYLCEA EGGVHLLTPQ PASCPDVSSC
RGSLRKTGCC YSCEEDSCQV RINTTILWHQ GCETEVNITF CEGSCPGASK YSAEAQAMQH
QCTCCQERRV HEETVPLHCP NGSAILHTYT HVDECGCTPF CVPAPMAPPH TRGFPAQEAT
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