MUC6_MOUSE
ID MUC6_MOUSE Reviewed; 2850 AA.
AC Q80T03; Q80Z22;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 29-SEP-2021, entry version 93.
DE RecName: Full=Mucin-6;
DE Short=MUC-6;
DE AltName: Full=Gastric mucin-6;
DE AltName: Full=Secreted gel-forming mucin-6;
DE Flags: Precursor;
GN Name=Muc6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=12676567; DOI=10.1016/s0888-7543(03)00036-3;
RA Desseyn J.-L., Laine A.;
RT "Characterization of mouse muc6 and evidence of conservation of the gel-
RT forming mucin gene cluster between human and mouse.";
RL Genomics 81:433-436(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1436-2850, AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=14984930; DOI=10.1016/j.bbaexp.2004.01.001;
RA Escande F., Porchet N., Bernigaud A., Petitprez D., Aubert J.-P.,
RA Buisine M.-P.;
RT "The mouse secreted gel-forming mucin gene cluster.";
RL Biochim. Biophys. Acta 1676:240-250(2004).
CC -!- FUNCTION: May provide a mechanism for modulation of the composition of
CC the protective mucus layer related to acid secretion or the presence of
CC bacteria and noxious agents in the lumen. Plays an important role in
CC the cytoprotection of epithelial surfaces and are used as tumor markers
CC in a variety of cancers. May play a role in epithelial organogenesis.
CC -!- SUBUNIT: Multimer; disulfide-linked. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed in stomach, duodenum and small intestine.
CC {ECO:0000269|PubMed:12676567, ECO:0000269|PubMed:14984930}.
CC -!- PTM: O-glycosylated. {ECO:0000250}.
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DR EMBL; AY184388; AAO47735.1; -; Genomic_DNA.
DR EMBL; AY184385; AAO47735.1; JOINED; Genomic_DNA.
DR EMBL; AY184387; AAO47735.1; JOINED; Genomic_DNA.
DR EMBL; AY184386; AAO47735.1; JOINED; Genomic_DNA.
DR EMBL; AJ511869; CAD54411.1; -; Genomic_DNA.
DR SMR; Q80T03; -.
DR STRING; 10090.ENSMUSP00000140483; -.
DR MEROPS; I08.952; -.
DR GlyGen; Q80T03; 6 sites.
DR iPTMnet; Q80T03; -.
DR PhosphoSitePlus; Q80T03; -.
DR MaxQB; Q80T03; -.
DR PaxDb; Q80T03; -.
DR PRIDE; Q80T03; -.
DR ProteomicsDB; 287330; -.
DR UCSC; uc009klu.2; mouse.
DR MGI; MGI:2663233; Muc6.
DR eggNOG; KOG1216; Eukaryota.
DR InParanoid; Q80T03; -.
DR PhylomeDB; Q80T03; -.
DR Reactome; R-MMU-913709; O-linked glycosylation of mucins.
DR Reactome; R-MMU-977068; Termination of O-glycan biosynthesis.
DR PRO; PR:Q80T03; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q80T03; protein.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0030277; P:maintenance of gastrointestinal epithelium; IEA:InterPro.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR030124; MUC6.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR014853; Unchr_dom_Cys-rich.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR11339:SF264; PTHR11339:SF264; 6.
DR Pfam; PF08742; C8; 3.
DR Pfam; PF01826; TIL; 2.
DR Pfam; PF00094; VWD; 4.
DR SMART; SM00832; C8; 3.
DR SMART; SM00215; VWC_out; 2.
DR SMART; SM00216; VWD; 3.
DR SUPFAM; SSF57567; SSF57567; 3.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS51233; VWFD; 3.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..2850
FT /note="Mucin-6"
FT /id="PRO_0000259497"
FT DOMAIN 43..256
FT /note="VWFD 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 344..399
FT /note="TIL 1"
FT DOMAIN 437..621
FT /note="VWFD 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DOMAIN 806..869
FT /note="TIL 2"
FT DOMAIN 908..1080
FT /note="VWFD 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT REPEAT 1440..1555
FT /note="1"
FT REPEAT 1556..1712
FT /note="2"
FT REPEAT 1713..1885
FT /note="3"
FT REPEAT 1886..2054
FT /note="4"
FT REPEAT 2055..2227
FT /note="5"
FT REPEAT 2228..2396
FT /note="6"
FT REPEAT 2397..2563
FT /note="7"
FT REPEAT 2564..2671
FT /note="8"
FT DOMAIN 2760..2849
FT /note="CTCK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT REGION 160..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1263..1363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1377..1400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1440..2671
FT /note="Approximate repeats"
FT /evidence="ECO:0000250"
FT REGION 1466..1504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1580..1600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1626..1650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1705..1813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1877..1942
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1968..1992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2049..2119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2219..2254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2276..2295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2306..2338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2370..2473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2511..2621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2634..2674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2692..2761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1291..1319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1320..1334
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1335..1363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 94
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 310
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 528
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 701
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1017
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1221
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 45..218
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 67..255
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 439..575
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 461..620
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 910..1044
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 932..1079
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 941..1041
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 959..966
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 2760..2807
FT /evidence="ECO:0000250"
FT DISULFID 2774..2821
FT /evidence="ECO:0000250"
FT DISULFID 2783..2841
FT /evidence="ECO:0000250"
FT DISULFID 2787..2843
FT /evidence="ECO:0000250"
FT DISULFID ?..2848
FT /evidence="ECO:0000250"
FT CONFLICT 1436..1446
FT /note="DITKTQNLFST -> ILHRRTSTSTS (in Ref. 2; CAD54411)"
FT /evidence="ECO:0000305"
FT CONFLICT 2793
FT /note="Missing (in Ref. 2; CAD54411)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2850 AA; 300401 MW; 9CD95F0845C79C9D CRC64;
MLRVRQLLLL LLFRGPLIDA GAWTGDVTDS DTEDNLQSSP EKGWCSTWGA GHFSTFDGHE
YNFQGMCNYI FTATCGDDVP ATFSIQLRRD MEGNISRIIM ELGASVVTVN KETISVRDIG
VVSLPYTSNG LQITPYGQSV QLVAKQLELE LVITWGPDAH LTEGQGGDEV GTPGTLKQES
KGSPAWAGSS LCIPTETNST TPQVQVETKY MGKLCGLCGN FDGKIDNEFL SEDGKLLEAH
KYATLQKLDD PNEICAHEAI PSTIILKTRY AQICNQLLTL VSPGCDVPKE TLMLSCQADM
AACARPGQPN CSCATLSEYS RRCSMTGQPV RNWRTPALCP MSQCPANQVY QECGEVCIKT
CSNPQHSCSS PCTFGCFCPH GTLLDDISGN QSCVPVNQCP CMLNGMVYGP GEITKTACQT
CQCTMGRWTC TKQPCPGHCS LEGGSFVTTF DARPYRFHGT CTYTLLQSPQ LPNEGTLMAV
YDKSGYSHSE TSLVAIMYLS KKDKIVISED EVITNNGDTK LLPYKTHNIT IFRQTSTHLQ
MATTFGLELV FQMQPVFQVY ITVGPQFKGQ TRGLCGNFNG DTTDDFTTSM GIDEGTASLF
VDSWRAGNCP AALEREMDPC SMSQLNKVCA ETHCSMLLKK GSVFEKCHSV VNPQPFYKRC
VYQACNYEET FPHICSALGA YAHACSARGI LLWGWRNSVD NCTVPCTGNR TFSYDSQACD
RTCLSLSDRE TECHVSPVPV DGCNCPEGTY LNHKAECVHK AQCPCLLDDY KFVQADQSTM
INGVICHCIN GRLSCPRQAE MFFASCPEPK TFQSCSQSSE DKFGAACAPT CQMLATGIDC
VPTKCESGCV CPKGLYENSD GQCVPAEECP CDYAGVSYPG GFELHTDCKT CTCSQGRWTC
QLSTQCPSTC VLYGEGHIIT FDGQRFVFDG DCEYMLATDD CGANSSQPTF KVLTENVICG
KSGVTCSRAI KISLGGLFIT MADSNYTVSG EEPLVHLKVK PSPLNLVLDI DIPGRLNLTL
VWNKHMSVSI KIRRATQDAL CGLCGNANGN MKDDFETRSK YVASNELEFV NSWKESPLCG
DASYAVDPCS LNTFRRSWAE RKCNIINSQT FAACHSKVYH LPYYEACVRD ACGCDTGGDC
ECLCDAVAAY AKACLDKGVC VDWRTPDFCP IYCDFYNTHT LVGENEYQYA QESNCTWHYQ
PCLCPGSLGS FPDTNTEGCY NCSQNEYFDH SEGTCVPCAP PTTTLPPTTT GSQPTTETTI
STEFHSSTSA NTPVAPSYLP GLPTPPPSAP SSTEELTVWT TPKESTVSSG EYPQTTMAAT
PPTSPWPPTS IPKSTPTELP VTQATSKPTA SSLSSSTKTT AELTESTTVT LLTLMPGMST
SQEGTPTSKI PVTQTTTHRV PSRCITNQST TMFQTTTVQE AEITQTLAPS TYTTNDITKT
QNLFSTAPHL SETSAVTAHQ STPTAVSANS IKPTMSSTGT PVVHTTSGTS SSPQTPRTTH
PSTTVAVSGT VHTTGLPSGT SVHTTTNFPT HSGPQSSLST HLPLFSTLSV TPTTEGLNTQ
STPIPAITNS LMTTGGLTGT PPVHTTSGTT SSPQTPRTTH PFSTVAVSNT KHTTGVSLET
SVQTTIASPT PSAPQTSLAT HLPFSSTSSV TPTSEVIITP TPQHTLSSAS TSTTTGNILP
TTIGKTGSPH TSVPVIYTTS AITQTKTSFS TDRTSTSTSA PHLSETSAVT AHQSTPTAVS
ANSIKPTMSS TGTPVVHTTS GTTSSPQTPR TTHPSTTVAV SGTVHTTGLP SGTSVHTTTN
FPTHSGPQSS LSTHLPLFST LSVTPTTEGL NTPTSPHSLS VASTSMPLMT VLPTTLEGTR
PPHTSVPVTY TTTAATQTKS SFSTDRTSAP HLSQPSTVTP TQSTPIPATT NSLMTTGGLT
GTPPVHTTSG TTSSPQTPRT THPFSTVAVS NTKHTTGVSL ETSVQTTIAS PTPSAPQTSL
ATHLPFSSTS SVTPTSEVII TPTPQHTLSS ASTSTTTGNI LPTTIGQTGS PHTSVPVIYT
TSAITQTKTS FSTDRTSTST SAPHLSETSA VTAHQSTPTA VSANSIKPTM SSTGTPVVHT
TSGTTSSPQT PRTTHPSTTV AVSGTVHTTG LPSGTSVHTT TNFPTHSGPQ SSLSTHLPLF
STLSVTPTTE GLNTPTSPHS LSAASTSMPL MTVLPTTLEG TRPPHTSVPV TYTTTAATQT
KSSFSTDRTS TPHLSQSSTV TPTQPTPIPA TTNSPMTTVG LTGTPVVHTP SGTSSIAHTP
HTTHSLPTAA SSSTTLSTAP QFRTSEQSTT TFPTPSAPQT SLVTSLPPFS TSSVSPTDEI
HITSTNPHTV SSVSMSRPVS TILQTTIEVT TPPNTSTPVT HSTSATTEAQ GSFSTERTST
SYLSHPSSTT VHQSTAGPVI TSIKSTMGVT GTPPVHTTSG TTSSPQTPHS THPISTAAIS
RTTGISGTPF RTPMKTTITF PTPSSLQTSM ATLFPPFSTS VMSSTEIFNT PTNPHSVSSA
STSRPLSTSL PTTIKGTGTP QTPVSDINTT SATTQAHSSF PTTRTSTSHL SLPSSMTSTL
TPASRSASTL QYTPTPSSVS HSPLLTTPTA SPPSSAPTFV SPTAASTVIS SALPTIHMTP
TPSSRPTSST GLLSTSKTTS HVPTFSSFSS KSTTAHLTSL TTQAATSGLL SSTMGMTNLP
SSGSPDINHT TRPPGSSPLP TSAFLSRSTS PTGSSSPSTP VSSSNPDSSV SSPPSHPGTC
SLQEEEHQIT YQGCVANVTL TRCQGFCASS VSFNKDTLQL ESSCGCCQPL STYKKQLSLP
CPDPDAPGQQ LTLTLQVFSS CVCSPLQCKN
