ID   MUCEN_RAT               Reviewed;         250 AA.
AC   Q6AY82;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Endomucin;
DE   Flags: Precursor;
GN   Name=Emcn;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Endothelial sialomucin, also called endomucin or mucin-like
CC       sialoglycoprotein, which interferes with the assembly of focal adhesion
CC       complexes and inhibits interaction between cells and the extracellular
CC       matrix. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- PTM: Highly O-glycosylated. Sialic acid-rich glycoprotein (By
CC       similarity). {ECO:0000250}.
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DR   EMBL; BC079155; AAH79155.1; -; mRNA.
DR   RefSeq; NP_001004228.1; NM_001004228.1.
DR   AlphaFoldDB; Q6AY82; -.
DR   SMR; Q6AY82; -.
DR   STRING; 10116.ENSRNOP00000033031; -.
DR   GlyGen; Q6AY82; 3 sites.
DR   PaxDb; Q6AY82; -.
DR   PRIDE; Q6AY82; -.
DR   Ensembl; ENSRNOT00000035700; ENSRNOP00000033031; ENSRNOG00000022910.
DR   GeneID; 295490; -.
DR   KEGG; rno:295490; -.
DR   CTD; 51705; -.
DR   RGD; 1303218; Emcn.
DR   eggNOG; ENOG502S6VA; Eukaryota.
DR   GeneTree; ENSGT00390000012139; -.
DR   HOGENOM; CLU_092835_0_0_1; -.
DR   InParanoid; Q6AY82; -.
DR   OMA; XPQSDKE; -.
DR   OrthoDB; 1471475at2759; -.
DR   PhylomeDB; Q6AY82; -.
DR   TreeFam; TF337783; -.
DR   PRO; PR:Q6AY82; -.
DR   Proteomes; UP000002494; Chromosome 2.
DR   Bgee; ENSRNOG00000022910; Expressed in lung and 20 other tissues.
DR   Genevisible; Q6AY82; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:HGNC-UCL.
DR   GO; GO:0030246; F:carbohydrate binding; ISS:HGNC-UCL.
DR   GO; GO:0001525; P:angiogenesis; ISS:HGNC-UCL.
DR   GO; GO:0098609; P:cell-cell adhesion; ISS:HGNC-UCL.
DR   GO; GO:0061484; P:hematopoietic stem cell homeostasis; ISO:RGD.
DR   GO; GO:0030155; P:regulation of cell adhesion; ISS:HGNC-UCL.
DR   InterPro; IPR010740; Endomucin.
DR   PANTHER; PTHR15869; PTHR15869; 1.
DR   Pfam; PF07010; Endomucin; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..250
FT                   /note="Endomucin"
FT                   /id="PRO_0000249727"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          24..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          105..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          210..250
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..66
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        214..239
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         226
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9R0H2"
FT   CARBOHYD        46
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        115
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        119
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   250 AA;  26516 MW;  5E84CFC5CCEA4B30 CRC64;
     MRLLQVTALF FLLSNSLCRG ENSKALTETS TTKASATTPD MVSITNKSTG GTPPKGTTNS
     ATPKTPLMPA LDSPTTPKHE TTTRGVIKNE VSTIKTTVAN PTISNAVSTL SSPQNKTENQ
     SSIRTTEISG TNQLPDDQKP KTTETPSASL TTAKTISQIQ DTEDGKITAT TSTTPSYSSV
     ILPVVIALIV ITVLVFTLVG LYRICWKRDP GTPESGNDQP QSDKESVKLL TVKTISHESG
     EHSAQGKAKN