MUCK_ACIAD
ID MUCK_ACIAD Reviewed; 413 AA.
AC P94131;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Cis,cis-muconate transport protein;
GN Name=mucK; OrderedLocusNames=ACIAD1681;
OS Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter.
OX NCBI_TaxID=62977;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9294455; DOI=10.1128/jb.179.18.5935-5942.1997;
RA Williams P.A., Shaw L.E.;
RT "mucK, a gene in Acinetobacter calcoaceticus ADP1 (BD413), encodes the
RT ability to grow on exogenous cis,cis-muconate as the sole carbon source.";
RL J. Bacteriol. 179:5935-5942(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33305 / BD413 / ADP1;
RX PubMed=15514110; DOI=10.1093/nar/gkh910;
RA Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L.,
RA Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N.,
RA Weissenbach J., Marliere P., Cohen G.N., Medigue C.;
RT "Unique features revealed by the genome sequence of Acinetobacter sp. ADP1,
RT a versatile and naturally transformation competent bacterium.";
RL Nucleic Acids Res. 32:5766-5779(2004).
CC -!- FUNCTION: Probable uptake of muconate.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Aromatic
CC acid:H(+) symporter (AAHS) (TC 2.A.1.15) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U87258; AAC27117.1; -; Genomic_DNA.
DR EMBL; CR543861; CAG68526.1; -; Genomic_DNA.
DR RefSeq; WP_004926552.1; NC_005966.1.
DR AlphaFoldDB; P94131; -.
DR SMR; P94131; -.
DR STRING; 62977.ACIAD1681; -.
DR TCDB; 2.A.1.15.4; the major facilitator superfamily (mfs).
DR EnsemblBacteria; CAG68526; CAG68526; ACIAD1681.
DR GeneID; 45234071; -.
DR KEGG; aci:ACIAD1681; -.
DR eggNOG; COG2814; Bacteria.
DR HOGENOM; CLU_001265_46_7_6; -.
DR OMA; LATWVPT; -.
DR OrthoDB; 1121832at2; -.
DR BioCyc; ASP62977:ACIAD_RS07750-MON; -.
DR Proteomes; UP000000430; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR004746; MFS_AAHS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00895; 2A0115; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..413
FT /note="Cis,cis-muconate transport protein"
FT /id="PRO_0000050310"
FT TOPO_DOM 1..16
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..37
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..53
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..85
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..112
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 134..145
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 167..171
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 193..228
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..249
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 250..266
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..287
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 288..293
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 315..318
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 319..339
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 340..352
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 353..376
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 377..382
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 383..403
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 404..413
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 413 AA; 45245 MW; 2D88CE31C4C5CC65 CRC64;
MYSNNQRSRI GSHTWKIAFL FAFLALLVDG ADLMLLSYSL NSIKAEFNLS TVEAGMLGSF
TLAGMAIGGI FGGWACDRFG RVRIVVISIL TFSILTCGLG LTQSFIQFGV LRFFASLGLG
SLYIACNTLM AEYVPTKYRT TVLGTLQAGW TVGYIVATLL AGWLIPDHGW RVLFYVAIIP
VLMAVLMHFF VPEPAAWQQS RLAPSKQTET VKTSAFKLIF QDKRNRNMFI LWALTAGFLQ
FGYYGVNNWM PSYLESELGM KFKEMTAYMV GTYTAMILGK ILAGFMADKL GRRFTYAFGA
IGTAIFLPLI VFYNSPDNIL YLLVIFGFLY GIPYGVNATY MTESFPTAIR GTAIGGAYNV
GRLGAAIAPA TIGFLASGGS IGLGFVVMGA AYFICGVIPA LFIKEKQYDP QQS
