MUCL2_MOUSE
ID MUCL2_MOUSE Reviewed; 138 AA.
AC P02815; Q3KQK8; Q62263; Q9DA65;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 09-DEC-2015, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Mucin-like protein 2 {ECO:0000312|MGI:MGI:98392};
DE AltName: Full=16.5 kDa submandibular gland glycoprotein {ECO:0000305};
DE AltName: Full=Salivary protein 1 {ECO:0000305};
DE Flags: Precursor;
GN Name=Mucl2 {ECO:0000312|MGI:MGI:98392};
GN Synonyms=Spt-1 {ECO:0000312|MGI:MGI:98392},
GN Spt1 {ECO:0000312|MGI:MGI:98392};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=DBA/2J {ECO:0000303|PubMed:6546617};
RC TISSUE=Submandibular gland {ECO:0000303|PubMed:6546617};
RX PubMed=6546617; DOI=10.1093/nar/12.3.1361;
RA Windass J.D., Mullins J.J., Beecroft L.J., George H., Meacock P.A.,
RA Williams B.R.G., Brammar W.J.;
RT "Molecular cloning of cDNAs from androgen-independent mRNA species of DBA/2
RT mouse sub-maxillary glands.";
RL Nucleic Acids Res. 12:1361-1376(1984).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=AKR/J {ECO:0000303|PubMed:2921944};
RC TISSUE=Submandibular gland {ECO:0000303|PubMed:2921944};
RX PubMed=2921944; DOI=10.1093/oxfordjournals.molbev.a040534;
RA Dickinson D.P., Mirels L., Tabak L.A., Gross K.W.;
RT "Rapid evolution of variants in a rodent multigene family encoding salivary
RT proteins.";
RL Mol. Biol. Evol. 6:80-102(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAB24419.1};
RC TISSUE=Testis {ECO:0000312|EMBL:BAB24419.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N {ECO:0000312|EMBL:AAI06152.1};
RC TISSUE=Salivary gland {ECO:0000312|EMBL:AAI06152.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=2482730; DOI=10.1007/bf02396156;
RA Dickinson D.P., Abel K., Near J., Taylor B.A., Gross K.W.;
RT "Genetic and tissue-specific variation in the expression of a closely
RT linked murine multigene family on chromosome 15 that encodes salivary and
RT lacrimal proteins.";
RL Biochem. Genet. 27:613-637(1989).
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in submandibular gland and lacrimal
CC gland. Not detected in other tissues. {ECO:0000269|PubMed:2482730}.
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DR EMBL; X00349; CAA25098.1; -; mRNA.
DR EMBL; M33974; AAA40132.1; -; mRNA.
DR EMBL; AK006124; BAB24419.1; -; mRNA.
DR EMBL; AC225888; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC106151; AAI06152.1; -; mRNA.
DR CCDS; CCDS57015.1; -.
DR PIR; A03298; WMMS16.
DR PIR; A30305; A30305.
DR RefSeq; NP_033293.2; NM_009267.2.
DR AlphaFoldDB; P02815; -.
DR SMR; P02815; -.
DR STRING; 10090.ENSMUSP00000044814; -.
DR GlyGen; P02815; 1 site.
DR PaxDb; P02815; -.
DR PeptideAtlas; P02815; -.
DR PRIDE; P02815; -.
DR Ensembl; ENSMUST00000037685; ENSMUSP00000044814; ENSMUSG00000036925.
DR GeneID; 20770; -.
DR KEGG; mmu:20770; -.
DR UCSC; uc029svn.1; mouse.
DR CTD; 20770; -.
DR MGI; MGI:98392; Mucl2.
DR VEuPathDB; HostDB:ENSMUSG00000036925; -.
DR GeneTree; ENSGT00530000067283; -.
DR OrthoDB; 1839157at2759; -.
DR PhylomeDB; P02815; -.
DR BioGRID-ORCS; 20770; 5 hits in 38 CRISPR screens.
DR ChiTaRS; Mucl2; mouse.
DR PRO; PR:P02815; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; P02815; protein.
DR Bgee; ENSMUSG00000036925; Expressed in ovary and 22 other tissues.
DR ExpressionAtlas; P02815; baseline and differential.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
PE 2: Evidence at transcript level;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..138
FT /note="Mucin-like protein 2"
FT /evidence="ECO:0000255"
FT /id="PRO_5004324585"
FT REGION 18..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..90
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 89
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 74..75
FT /note="AN -> SY (in Ref. 1; CAA25098)"
FT /evidence="ECO:0000305"
FT CONFLICT 78
FT /note="S -> T (in Ref. 1; CAA25098)"
FT /evidence="ECO:0000305"
FT CONFLICT 109
FT /note="D -> E (in Ref. 1; CAA25098, 2; AAA40132 and 5;
FT AAI06152)"
FT /evidence="ECO:0000305"
FT CONFLICT 119
FT /note="N -> D (in Ref. 1; CAA25098 and 2; AAA40132)"
FT /evidence="ECO:0000305"
FT CONFLICT 120
FT /note="M -> I (in Ref. 2; AAA40132)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 138 AA; 14802 MW; FF57145462FADFF7 CRC64;
MKFLALLVLL GVSTILVSCQ DPETNSTETS GTADSAGENT GSETQADSTD QNQEVDSSDS
VEEENVNTDD TNTANEASEE DNKEELNDNS TGDNTSDQNS GVDNTETEDE SNAKTKLENM
KTVIKSGVEK LKNFLQRG
