MUCL3_MOUSE
ID MUCL3_MOUSE Reviewed; 500 AA.
AC Q3TNW5;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Mucin-like protein 3 {ECO:0000305};
DE AltName: Full=Diffuse panbronchiolitis critical region protein 1 homolog;
DE Flags: Precursor;
GN Name=Mucl3 {ECO:0000312|MGI:MGI:2685476};
GN Synonyms=Dpcr1 {ECO:0000312|MGI:MGI:2685476}, Gm630;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Lung, and Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: May modulate NF-kappaB signaling and play a role in cell
CC growth. {ECO:0000250|UniProtKB:Q3MIW9}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q3MIW9};
CC Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q3MIW9}.
CC Cytoplasm {ECO:0000250|UniProtKB:Q3MIW9}.
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DR EMBL; AK131887; BAE20852.1; -; mRNA.
DR EMBL; AK164929; BAE37972.1; -; mRNA.
DR CCDS; CCDS28701.1; -.
DR RefSeq; NP_001028538.1; NM_001033366.3.
DR AlphaFoldDB; Q3TNW5; -.
DR STRING; 10090.ENSMUSP00000093120; -.
DR GlyGen; Q3TNW5; 2 sites.
DR iPTMnet; Q3TNW5; -.
DR PhosphoSitePlus; Q3TNW5; -.
DR PaxDb; Q3TNW5; -.
DR PRIDE; Q3TNW5; -.
DR ProteomicsDB; 279562; -.
DR Antibodypedia; 2593; 169 antibodies from 22 providers.
DR Ensembl; ENSMUST00000095467; ENSMUSP00000093120; ENSMUSG00000073408.
DR GeneID; 268949; -.
DR KEGG; mmu:268949; -.
DR UCSC; uc012aro.1; mouse.
DR CTD; 135656; -.
DR MGI; MGI:2685476; Mucl3.
DR VEuPathDB; HostDB:ENSMUSG00000073408; -.
DR eggNOG; ENOG502S7U9; Eukaryota.
DR GeneTree; ENSGT00390000016847; -.
DR HOGENOM; CLU_040657_1_0_1; -.
DR InParanoid; Q3TNW5; -.
DR OMA; TFGLQCC; -.
DR OrthoDB; 840286at2759; -.
DR PhylomeDB; Q3TNW5; -.
DR TreeFam; TF338742; -.
DR BioGRID-ORCS; 268949; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Mucl3; mouse.
DR PRO; PR:Q3TNW5; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q3TNW5; protein.
DR Bgee; ENSMUSG00000073408; Expressed in stomach and 21 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR026623; MUCL3.
DR PANTHER; PTHR22094; PTHR22094; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cytoplasm; Glycoprotein; Membrane; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..500
FT /note="Mucin-like protein 3"
FT /id="PRO_0000318687"
FT TOPO_DOM 28..429
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 430..450
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 451..500
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 55..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 275..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 108
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 148
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 500 AA; 54310 MW; B3BDC0AB0230DB2B CRC64;
MAQPTSGLYS TFGFFICLLF FPASWEAGAN TFQELQKTGE PPKFDHLLPL TQGLTHRASS
DQKTSRQHPP DLPEATATQK AKNQCNTTRL VKPVHTPLDN AKAADYGNTT VRHEMPPASE
KDLSSQGKHL MARNERSADD PRSTTSENGS DGKRLTSAPR RNTSCMPSTR RTSLTTKSGM
RASPMGASAS LRTTSQKPTT FHVSELIRQS SSPVYATETP RTSYNTLKTL TTSGPEHHTI
PFASDKSVQI TTEHIKEATS ASEITRTQST FTKYEGKTSP ASESSSQAQV LPIKHHTTSA
SENTIPVSAK STPSTEKATK PTASPTVFQR KTIVATKTVR ATRTSERTPV FLETTQPAKA
TEDKSSTVPS HVHKTETMHQ GTVGSLTSRT NLGLSTSEAH YPQQSTHSLP GGLHAAGETG
ENNSFPVWAI VIVILMAVII LLVFIGLILL VSCASRARHV LTQNSEEPEP QPEDKGSRNS
YPVYLMEQQN LNLNQIPSPP
