ID   MUCL3_RAT               Reviewed;         470 AA.
AC   Q6MG22;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Mucin-like protein 3 {ECO:0000305};
DE   AltName: Full=Diffuse panbronchiolitis critical region protein 1 homolog;
DE   Flags: Precursor;
GN   Name=Mucl3 {ECO:0000312|RGD:1303125};
GN   Synonyms=Dpcr1 {ECO:0000312|RGD:1303125};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15060004; DOI=10.1101/gr.1987704;
RA   Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H.,
RA   Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.;
RT   "The genomic sequence and comparative analysis of the rat major
RT   histocompatibility complex.";
RL   Genome Res. 14:631-639(2004).
CC   -!- FUNCTION: May modulate NF-kappaB signaling and play a role in cell
CC       growth. {ECO:0000250|UniProtKB:Q3MIW9}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q3MIW9};
CC       Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q3MIW9}.
CC       Cytoplasm {ECO:0000250|UniProtKB:Q3MIW9}.
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DR   EMBL; BX883047; CAE84025.1; -; Genomic_DNA.
DR   RefSeq; NP_001003965.1; NM_001003965.1.
DR   AlphaFoldDB; Q6MG22; -.
DR   STRING; 10116.ENSRNOP00000060680; -.
DR   GlyGen; Q6MG22; 2 sites.
DR   PaxDb; Q6MG22; -.
DR   GeneID; 406199; -.
DR   KEGG; rno:406199; -.
DR   CTD; 135656; -.
DR   RGD; 1303125; Mucl3.
DR   VEuPathDB; HostDB:ENSRNOG00000042287; -.
DR   eggNOG; ENOG502S7U9; Eukaryota.
DR   HOGENOM; CLU_040657_1_0_1; -.
DR   InParanoid; Q6MG22; -.
DR   OMA; TFGLQCC; -.
DR   OrthoDB; 840286at2759; -.
DR   PhylomeDB; Q6MG22; -.
DR   PRO; PR:Q6MG22; -.
DR   Proteomes; UP000002494; Chromosome 20.
DR   Bgee; ENSRNOG00000042287; Expressed in stomach and 3 other tissues.
DR   ExpressionAtlas; Q6MG22; differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR026623; MUCL3.
DR   PANTHER; PTHR22094; PTHR22094; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cytoplasm; Glycoprotein; Membrane; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..470
FT                   /note="Mucin-like protein 3"
FT                   /id="PRO_0000318688"
FT   TOPO_DOM        30..401
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        402..422
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        423..470
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          57..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          248..318
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        69..85
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        132..148
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        167..190
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        201..225
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        256..271
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        284..318
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        122
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        325
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   470 AA;  51393 MW;  98B618A1C7DDF2AC CRC64;
     MAQMTSGLYP MFGFFICLLF LPASWEAGAN TFQELQKTGE PSIFDHLLPL TPGLTRRALS
     DHKNSGQHPP DLPKSTATQK PKRQCNTVRL VKPVHKPIDD AKAADYGNTT VGHEPFPASE
     KNLSSQGKHP MARNERSADD HGSTNSEKRS DGGHSTSAPM RKISCKPVTR TSGTPVSSTE
     TSTKLRTTSQ KPETSSHDSD LIRKSTSLPV KSTEVSRTSY RTPRSLGAER HTIPFTSDKS
     IQLTIEHTKE ATRSQSTPTK YERETRSASE RISRAHVPPV ENHTPSAGET TTQVSAKSTK
     HTEEATTSTT EKATKAPERP TVNLNTTGLV KAMENTSTAP SPHLHKTETA HQGITGSLTS
     RMDLRPITSE AHHLQQNTHS LPGGLHSVQE REGSNSFPAW AIVVVILMAV IILLIFLGLI
     FLVSCASRAR HQLTQNSEDA EPEDKGGRNS YPVYLMEQQN LNLNQISSPP