ID   MUCM_RABIT              Reviewed;         479 AA.
AC   P04221;
DT   20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 2.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Ig mu chain C region membrane-bound form;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (A2 ALLOTYPE).
RX   PubMed=6418803;
RA   Bernstein K.E., Alexander C.B., Reddy E.P., Mage R.G.;
RT   "Complete sequence of a cloned cDNA encoding rabbit secreted mu-chain of
RT   VHa2 allotype: comparisons with VHa1 and membrane mu sequences.";
RL   J. Immunol. 132:490-495(1984).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC         Comment=During differentiation, B-lymphocytes switch from expression
CC         of isoform Membrane-bound to isoform Secreted.;
CC       Name=Membrane-bound;
CC         IsoId=P04221-1; Sequence=Displayed;
CC       Name=Secreted;
CC         IsoId=P03988-1; Sequence=External;
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DR   EMBL; K01357; AAA31293.1; -; mRNA.
DR   PIR; A02165; MHRBM.
DR   AlphaFoldDB; P04221; -.
DR   SMR; P04221; -.
DR   STRING; 9986.ENSOCUP00000011642; -.
DR   eggNOG; ENOG502R54U; Eukaryota.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0034987; F:immunoglobulin receptor binding; IPI:AgBase.
DR   Gene3D; 2.60.40.10; -; 4.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR013151; Immunoglobulin.
DR   Pfam; PF07654; C1-set; 3.
DR   Pfam; PF00047; ig; 1.
DR   SMART; SM00407; IGc1; 4.
DR   SUPFAM; SSF48726; SSF48726; 4.
DR   PROSITE; PS50835; IG_LIKE; 4.
DR   PROSITE; PS00290; IG_MHC; 3.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW   Immunoglobulin domain; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           <1..479
FT                   /note="Ig mu chain C region membrane-bound form"
FT                   /id="PRO_0000153626"
FT   TRANSMEM        459..476
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..106
FT                   /note="CH1"
FT   REGION          107..222
FT                   /note="CH2"
FT   REGION          223..327
FT                   /note="CH3"
FT   REGION          328..458
FT                   /note="CH4"
FT   CARBOHYD        46
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        114
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        212
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        261
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        277
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        284
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        14
FT                   /note="Interchain (with light chain)"
FT                   /evidence="ECO:0000305"
FT   DISULFID        28..90
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        137..200
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        219
FT                   /note="Interchain (with heavy chain)"
FT                   /evidence="ECO:0000305"
FT   DISULFID        249..308
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        296
FT                   /note="Interchain (with heavy chain)"
FT                   /evidence="ECO:0000305"
FT   DISULFID        356..418
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   NON_TER         1
SQ   SEQUENCE   479 AA;  52351 MW;  689C637A47BE19FC CRC64;
     VSLSSPTLYP LVSCEGALTD GNLVAMGCLA RDFLPSSVTF SWSFKNNSEI SSRTVRTFPV
     VKRGDKYMAT SQVLVPSKDV LQGTEEYLVC KVQHSNSNRD LRVSFPVDSE LPPNVSVFIP
     PRDSFSGSGT RKSRLICQAT GFSPKQISVS WLRDGQKVES GVLTKPVEAE TKGAGPATFS
     ISSMLTITES DWLSQSLYTC RVDHRGIFFD KNVSMSSECS TTPSPGIQVF PIAPSFADTF
     LSKSARLICL VTDLTTYGSL NISWASHNGK ALDTHMNITE SHPNATFSAM GEASVCAEDW
     ESGEQFTCTV THADLPFPLK HTISKSREVA KHPPAVYVLP PAREQLVLRE SATVTCLVKG
     FSPADVFVQW QQRGQPLSSD KYVTSAPAPE PQAPGLYFTH STLTVTEEDW NSGETFTCVV
     GHEALPHMVT ERTVDKSTEG EVGAEEEGFE NLWTTASTFI VLFLLSLFYS TTVTLFKVK