MUG24_SCHPO
ID MUG24_SCHPO Reviewed; 654 AA.
AC O13674;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 128.
DE RecName: Full=Meiotically up-regulated gene 24 protein;
GN Name=mug24; ORFNames=SPCC74.09;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION IN MEIOSIS.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes required for
RT critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Has a role in meiosis. {ECO:0000269|PubMed:16303567}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329672; CAA20839.1; -; Genomic_DNA.
DR PIR; T41584; T41584.
DR RefSeq; NP_588373.1; NM_001023364.2.
DR AlphaFoldDB; O13674; -.
DR SMR; O13674; -.
DR BioGRID; 276049; 4.
DR STRING; 4896.SPCC74.09.1; -.
DR iPTMnet; O13674; -.
DR PaxDb; O13674; -.
DR EnsemblFungi; SPCC74.09.1; SPCC74.09.1:pep; SPCC74.09.
DR GeneID; 2539486; -.
DR KEGG; spo:SPCC74.09; -.
DR PomBase; SPCC74.09; mug24.
DR VEuPathDB; FungiDB:SPCC74.09; -.
DR eggNOG; KOG0118; Eukaryota.
DR HOGENOM; CLU_419298_0_0_1; -.
DR InParanoid; O13674; -.
DR OMA; FHYIPEK; -.
DR PhylomeDB; O13674; -.
DR PRO; PR:O13674; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0003723; F:RNA binding; ISM:PomBase.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR039171; Cwc2/Slt11.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR14089; PTHR14089; 2.
DR Pfam; PF00076; RRM_1; 2.
DR SMART; SM00360; RRM; 4.
DR SUPFAM; SSF54928; SSF54928; 2.
DR PROSITE; PS50102; RRM; 3.
PE 1: Evidence at protein level;
KW Cytoplasm; Meiosis; Reference proteome; Repeat; RNA-binding.
FT CHAIN 1..654
FT /note="Meiotically up-regulated gene 24 protein"
FT /id="PRO_0000082024"
FT DOMAIN 299..355
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 409..482
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 500..571
FT /note="RRM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 383..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 654 AA; 73881 MW; CEC410AEAE6853DF CRC64;
MAIMHKIGCA GSEVETDRVL EKDQANNGHF VDSDCCFQET GSTGTANSIC TLNDSEDDNS
SLNSVDNNEC TNLDCGGKKH KNLSPNPSFH VNINAAEFIP KSHNGYAPKS MNPPPEQLDS
PCYPHFDQDS SSVIYPSPPS TYYPNMYVSA NTFIPMPYAH YTDNMYHAKP VNRPNFLPRE
GTPPPFAQQP AEQFSPFNSE YESLLDFRAL ILGNLPVDYK ISELLSLIHS GPLEKIQSNP
GKRRIIITFL DSADAFFFYE RYHPRGFIFH GRPLKLTFAR PSPLPESIQN FCSNTAASRN
VFIGNLPSSY HEKEIEEAFG KFGKIEHIKI LSKKNIAFVH FLNIRDAIKV VRTLSCDPDY
HSWRIFFGSD RCANHPPSFD ERSCFTSKQN PDTTSDRCRQ QESKDNGNRT VFLGNLHTKT
KGHEICDLIR HGGLQDFHYI PEKHICFVTF ITYSAANAFH DYLAEEEVLL HGRRIKVGWG
KESGPLPRVL EDSILMGASR NVYFSHISDS LTTEELELIL RQYGEIESIK YLKNRSSGFV
AYTNISNAMK AVNGLPIHPL FKKSKIRYAP DRCEQELQKS KSNSPIQQNV PLQQFITPPF
SYPVAYCPAI PPGSDPILNF GIQYQPFIPF TAVPSFPFNC NVPNYPQTSD HEND
