MUG28_SCHPO
ID MUG28_SCHPO Reviewed; 609 AA.
AC Q9UT83;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 118.
DE RecName: Full=Meiotically up-regulated gene 28 protein;
GN Name=mug28; ORFNames=SPAC343.07;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION IN SPORULATION.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes required for
RT critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Has a role in sporulation. {ECO:0000269|PubMed:16303567}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329670; CAB52270.1; -; Genomic_DNA.
DR PIR; T38656; T38656.
DR RefSeq; NP_593427.1; NM_001018860.1.
DR AlphaFoldDB; Q9UT83; -.
DR BioGRID; 279596; 15.
DR STRING; 4896.SPAC343.07.1; -.
DR PaxDb; Q9UT83; -.
DR EnsemblFungi; SPAC343.07.1; SPAC343.07.1:pep; SPAC343.07.
DR GeneID; 2543165; -.
DR KEGG; spo:SPAC343.07; -.
DR PomBase; SPAC343.07; mug28.
DR VEuPathDB; FungiDB:SPAC343.07; -.
DR eggNOG; KOG0118; Eukaryota.
DR HOGENOM; CLU_463928_0_0_1; -.
DR InParanoid; Q9UT83; -.
DR OMA; HPSEAMQ; -.
DR PhylomeDB; Q9UT83; -.
DR Reactome; R-SPO-450520; HuR (ELAVL1) binds and stabilizes mRNA.
DR PRO; PR:Q9UT83; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:0005628; C:prospore membrane; IDA:PomBase.
DR GO; GO:0003723; F:RNA binding; ISM:PomBase.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 2.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; SSF54928; 2.
DR PROSITE; PS50102; RRM; 2.
PE 1: Evidence at protein level;
KW Cytoplasm; Meiosis; Reference proteome; Repeat; RNA-binding; Sporulation.
FT CHAIN 1..609
FT /note="Meiotically up-regulated gene 28 protein"
FT /id="PRO_0000278491"
FT DOMAIN 20..103
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 419..499
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
SQ SEQUENCE 609 AA; 68548 MW; 0ADE9A51603AB8F3 CRC64;
MIALEKLSEK NKRSTKKCEI SIYVGNLPST CQSSDLHELF EPFGNFSKFH MLSRKKNKST
DSKSPTLFAF ITFENKCSAD NAIASLNGSS FQGNTLKVEY THIVERYKNK LENGVDQIHH
SNNEKAKIRF SKIEKYTKET RPTVSEVRVS TKDKKEYSMN TSNLVQSNPP KVHDKENAFA
EATGTSILSS KAVQTLLVSD FTENEPKHLS IRPNCKDNNT PSISNTFIEP YKENNTEHLH
LKSAFEPCQM MPGMLLEQNP QFLYDNPSIF VIGILNLPLK VSPVELYNEF SNHGHILGVA
INQSINEDMT HYAEVAVSTY ESCIEIIEKF HAIAYEGSIL QLFIKQPVQG FCSNLLNHPE
GTMTNLLPPN MEMPQPFEIP VIAKTSALPN PFISFPSFQT SYETTVTPTP TSTPTIDPCN
LFVKNLDDNI VGNTQQLEEL FSKFGRIKSC TLASYPSTEI SKGYGFVSFS HPFEAVQAIN
TLNGVLFGKK RLFVNYAEKR EDRKKRLSAI FSQSYPPVVP SPSLTIPMAT EPQILEYHQE
WPQPLIQSIQ QHGYSDPRQT LPTRLDSCAA KLREAVISNE NLNPSHKFGI KHSTFKTSLS
PLTNIVLNQ
