ID   MUG45_SCHPO             Reviewed;         819 AA.
AC   O94254;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Meiotically up-regulated gene 45 protein;
GN   Name=mug45; ORFNames=SPBP8B7.04;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   FUNCTION IN MEIOSIS.
RX   PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA   Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA   Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA   Smith G.R., Moreno S.;
RT   "A large-scale screen in S. pombe identifies seven novel genes required for
RT   critical meiotic events.";
RL   Curr. Biol. 15:2056-2062(2005).
CC   -!- FUNCTION: Has a role in meiosis. {ECO:0000269|PubMed:16303567}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; CU329671; CAA21789.1; -; Genomic_DNA.
DR   PIR; T40798; T40798.
DR   RefSeq; NP_596511.1; NM_001022432.2.
DR   AlphaFoldDB; O94254; -.
DR   SMR; O94254; -.
DR   BioGRID; 277887; 5.
DR   STRING; 4896.SPBP8B7.04.1; -.
DR   PaxDb; O94254; -.
DR   EnsemblFungi; SPBP8B7.04.1; SPBP8B7.04.1:pep; SPBP8B7.04.
DR   GeneID; 2541376; -.
DR   KEGG; spo:SPBP8B7.04; -.
DR   PomBase; SPBP8B7.04; mug45.
DR   VEuPathDB; FungiDB:SPBP8B7.04; -.
DR   HOGENOM; CLU_349894_0_0_1; -.
DR   OMA; ALGCCEF; -.
DR   PRO; PR:O94254; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Meiosis; Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..819
FT                   /note="Meiotically up-regulated gene 45 protein"
FT                   /id="PRO_0000278500"
FT   TRANSMEM        797..817
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   819 AA;  94732 MW;  AC21856B6C0D3E37 CRC64;
     MKNLANIKLY WNENDFLIAD MLLILKLSPR SSSDCLLDLR DRKWELVCCK ELNIGNERNP
     LNVPLFELPV NSLELQNSVS NDMFKHVYSQ NVELNHKTQV DFTEQLIPKK SLNKLNGTLR
     ETMSRMPSFE SISLSETSNA LDDSCFNDDW ITIESEFSPP IDRGMTLEAM DSQNDTLFTS
     KQLNNGPNFP VEKATFFLES NMGLSQRAAA TSTTPVCNIS SVTSAINSVG EISNASHSSS
     TSELPCTYGN TSSIFQVKNE MSNIKSAISE GYIAHDQQSK KVSVQNIKKE FLIPFEFSLE
     GGFLNYNKTF SNLYKVLSET EKTRDSKVWF TFRLVLKTKP LYASESEFYE TKLNFFTFPL
     ECAINFHIDC SCFDDWRLFS LKESSSVAVP IPKIKKESGR SMFQSLLFQF NHCIPFRLSW
     INYKQSQLNI ILTETTIRPR ICAAYQKLEY NILVLLNEKP SSGSQLILSA SPTCTIENIY
     IENTRLHFSK SQTPEQTVIS FIDVQCVKVT EATKTLELSV ILSERLVYET ALKLPVIKYV
     KGDNRFCFKQ LLEYYDIYLK FKLLADWRLL TNPVLQIQEI SDYCHFKLLK KVNRNLQIKT
     NYPTQEFHLL RPTIKILQIS KHEYFLHFSS SYIFNDARER DVYGVKLSKN MWISWAYVDN
     CEANFFCKDG TYFFRTTSRK QILLLEIGIL IKPERYNLFK YRVYLPQFLP PTDSRTLVEF
     QTIVYTNSTL LFDGSFYFSQ NGGFDFEPRQ NYTYFDFKSE FIILQNSYSI YGPAKNIIKL
     LLELIEVILN VNVSTTAMCL LTLLIGIYLI LQVVFIYTN