ID   MUG4_SCHPO              Reviewed;         845 AA.
AC   O94719;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Meiotically up-regulated gene 4 protein;
GN   Name=mug4; ORFNames=SPCC1393.07c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   INTERACTION WITH MCP6.
RX   PubMed=16111942; DOI=10.1016/j.cub.2005.07.058;
RA   Tanaka K., Kohda T., Yamashita A., Nonaka N., Yamamoto M.;
RT   "Hrs1p/Mcp6p on the meiotic SPB organizes astral microtubule arrays for
RT   oscillatory nuclear movement.";
RL   Curr. Biol. 15:1479-1486(2005).
CC   -!- FUNCTION: Has a role in meiosis.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CU329672; CAB38163.1; -; Genomic_DNA.
DR   PIR; T40955; T40955.
DR   RefSeq; NP_587965.1; NM_001022956.2.
DR   AlphaFoldDB; O94719; -.
DR   SMR; O94719; -.
DR   BioGRID; 275467; 2.
DR   STRING; 4896.SPCC1393.07c.1; -.
DR   PaxDb; O94719; -.
DR   EnsemblFungi; SPCC1393.07c.1; SPCC1393.07c.1:pep; SPCC1393.07c.
DR   GeneID; 2538889; -.
DR   KEGG; spo:SPCC1393.07c; -.
DR   PomBase; SPCC1393.07c; mug4.
DR   VEuPathDB; FungiDB:SPCC1393.07c; -.
DR   HOGENOM; CLU_334676_0_0_1; -.
DR   OMA; RICEFEA; -.
DR   PRO; PR:O94719; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Meiosis; Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..845
FT                   /note="Meiotically up-regulated gene 4 protein"
FT                   /id="PRO_0000278485"
FT   TRANSMEM        726..746
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          122..158
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   845 AA;  94518 MW;  41CB0F8F14295D80 CRC64;
     MTPPSSSSHF PSPSSANNDF HSLSLEAHGS LSDKFISQFR LNYTIIPIAQ KSNISLPFLT
     LSPCSFTICS LRARLHSLHG PSTVFLKRET SQISARVNDE NGFTASPSFF SVDCFDELFP
     TLSTTDEQPK EPSIISISSS SSDPSSSPPP SSSLLKTPDN DFCARPETFV KSDTADIKLQ
     IHQNNLVLTF LDTTTVSKVN IVLEIHIPVL RDFVTFEQYI PLMFLPSPFE TILSFDNLKS
     DSPSSDLHLG WDHTVSKESM SQSIAEVLNP YNKGVSRSLN DATNMETYHW SPFPPQFSTF
     NDNALRLRIY YKPKSWLPKN SSCSLSVDVK ATLLETTPPS CEVSYNLLLT CRSSNRFRLF
     PASTPNSNGL CRNDSKCRFL MILPETIIKS PSSFIGDSYN IANIDPPSSM NVQSSEFRVG
     EVQSFTTNTS SFAFTFKEIV QLGSKASVPM ILFPAPSNYK LTIEKPPFPC DLTIPHTAIN
     DSWLPMKLKE TNAISYYRKT CSSCKYPFQF FINKLPFYQS PSLPLSATYV WIASALLSVQ
     PGNGSFNIML SLKFVSSMKP GTELLTIKQP KSSLLNWGLV NGYPKTEGRI VLLPRNDIVL
     IQADQPTSVF DLCWTIKPTY EKSSNFSCLQ LPIPVLNTPI LTPVTINIQS TTYYLIGYAN
     QNSKKTLDQP TSLLVLGCKA KNVSELILSY LPEKPIPDGA PIVTNVVETN KTNEAPSSFR
     KCLQQFLVFL TFTGMTLFIL YQLTFPYGVA KDNSSFIDTP LPHSCEMEKS LNVLQHKVLQ
     LQAVNMKLHD YYEKEPTEIY KTVSVTSTQI MPAVTKMSSF ELEREQFHKA FGFLRLNRKK
     DDNAN