MUG60_SCHPO
ID MUG60_SCHPO Reviewed; 663 AA.
AC O74359;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=Meiotically up-regulated gene 60 protein;
GN Name=mug60; ORFNames=SPBC28E12.02, SPBC9B6.13;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION IN MEIOSIS.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes required for
RT critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Has a role in meiosis. {ECO:0000269|PubMed:16303567}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, spindle pole body {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329671; CAB42374.1; -; Genomic_DNA.
DR PIR; T40039; T40039.
DR RefSeq; NP_595755.1; NM_001021655.2.
DR AlphaFoldDB; O74359; -.
DR BioGRID; 277105; 15.
DR STRING; 4896.SPBC28E12.02.1; -.
DR PaxDb; O74359; -.
DR EnsemblFungi; SPBC28E12.02.1; SPBC28E12.02.1:pep; SPBC28E12.02.
DR GeneID; 2540579; -.
DR KEGG; spo:SPBC28E12.02; -.
DR PomBase; SPBC28E12.02; -.
DR VEuPathDB; FungiDB:SPBC28E12.02; -.
DR eggNOG; KOG2208; Eukaryota.
DR HOGENOM; CLU_416281_0_0_1; -.
DR InParanoid; O74359; -.
DR OMA; FSENLWA; -.
DR PhylomeDB; O74359; -.
DR PRO; PR:O74359; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005844; C:polysome; IBA:GO_Central.
DR GO; GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoskeleton; Meiosis; Nucleus; Reference proteome; RNA-binding.
FT CHAIN 1..663
FT /note="Meiotically up-regulated gene 60 protein"
FT /id="PRO_0000278492"
FT DOMAIN 578..644
FT /note="KH"
SQ SEQUENCE 663 AA; 75492 MW; 6898B18AC142A8EA CRC64;
MDSHVLAFPI PDPSTPPPEE ASLYASKCDY YESDIYSQIR RLTEEKCIET EKELPVNIKL
HVKHKGMSIS SSRNELVVTV SGNYKNVYTA KIKILQAIPK ILISKLVLEE PLENLLFDED
GYVYEDTMKH LDKITEITGA KIYIMHRSMC HDIDFQLRTD SGFSNRLNEQ QSFYQRHLES
TRHEFSCQKN AENSFFIVFY GDYCSVEHAR IRVLALMDEI RGLSVVAIAT SVSFQPILVG
KAFSSTAGMK ATESINIYTL PFCSDSIPRL QTLPALNSSK IIITGEEEKL QRLEEAFYYA
EEHLKLFTHV TEISFVKLFE FLAYEMDELR LIMEENSSFI RFPEYFKEGG ETSPENSKVK
IYSSSIANSE KTALRLAKLA SKYVQGKTQF GVEDNEDFLR VAGSWRRAST IEKGVSSSEL
SSIVSSTGSI VETNGIGEKM SFSPLKKLSI PPTEFVAQIA IICMASGVEM LLKTNGIEYF
GQENTVPIAM DKASKIFYKF GQSQWHQILL EAPTKDQDFI SGKKNGKLDK VKQQCRFNLK
NGDILFCPQS TSIFTVDIYS DELERVIKGM NTMLLEFPAE MHFYVPEEIH KKLIGFRGEQ
IQRVTKLYNS YIEFSTTPFD CYGHNVLIRT PSKFSENLWA VRSLFIKTAE GLGYDIPKYL
FAN
