MUG62_SCHPO
ID MUG62_SCHPO Reviewed; 1487 AA.
AC Q09773;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2016, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Meiotically up-regulated gene 62 protein;
GN Name=mug62; ORFNames=SPAC22F3.04;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION IN MEIOSIS.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes required for
RT critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [4]
RP GENE MODEL REVISION.
RX PubMed=24929437; DOI=10.1038/nsmb.2843;
RA Duncan C.D., Mata J.;
RT "The translational landscape of fission-yeast meiosis and sporulation.";
RL Nat. Struct. Mol. Biol. 21:641-647(2014).
CC -!- FUNCTION: Has a role in meiosis. {ECO:0000269|PubMed:16303567}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole
CC body {ECO:0000269|PubMed:16823372}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA91069.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CU329670; CAA91069.1; ALT_SEQ; Genomic_DNA.
DR PIR; T38187; S62419.
DR RefSeq; NP_593037.1; NM_001018436.2.
DR AlphaFoldDB; Q09773; -.
DR SMR; Q09773; -.
DR BioGRID; 278288; 10.
DR STRING; 4896.SPAC22F3.04.1; -.
DR PaxDb; Q09773; -.
DR PRIDE; Q09773; -.
DR EnsemblFungi; SPAC22F3.04.1; SPAC22F3.04.1:pep; SPAC22F3.04.
DR GeneID; 2541797; -.
DR KEGG; spo:SPAC22F3.04; -.
DR PomBase; SPAC22F3.04; mug62.
DR VEuPathDB; FungiDB:SPAC22F3.04; -.
DR eggNOG; KOG3628; Eukaryota.
DR HOGENOM; CLU_000737_0_0_1; -.
DR InParanoid; Q09773; -.
DR PRO; PR:Q09773; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005739; C:mitochondrion; ISS:PomBase.
DR GO; GO:0044732; C:mitotic spindle pole body; HDA:PomBase.
DR GO; GO:0003824; F:catalytic activity; ISM:PomBase.
DR GO; GO:0006085; P:acetyl-CoA biosynthetic process; ISS:PomBase.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR CDD; cd05905; Dip2; 2.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; -; 2.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR037337; Dip2-like_dom.
DR Pfam; PF00501; AMP-binding; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoskeleton; Meiosis; Reference proteome.
FT CHAIN 1..1487
FT /note="Meiotically up-regulated gene 62 protein"
FT /id="PRO_0000116399"
SQ SEQUENCE 1487 AA; 169114 MW; 3292E60480F12D25 CRC64;
MSLKSFFNFN KKTKLHDIEE DVISEIGSAG SALRTDAHML KANDVYYKSE TDSHTVLRFM
KPSENEKIHP VRHSKYEDKS KLPFETIPDP VLKYVKRARD AELQPQLAKV SQKLFADIST
ATAAEKLQFT VPRRARFEIN DPRNPTFSMM ALQDIISVLE YRRNKNPTST AHICIDKKGK
EAVSYSWDKI LNRAKQFASV AQNHVGLKPG TRVILYYRKS EASEYIISIF GCLLLGIVVI
PLSPSSSSES LKLVVNEEKV RVAFTTEATY RIFIKDTEVN NAKSLAWWKS NDFTNYKFEQ
IKQYRMRAND TVLIDYTFSS STYNDIKAVY TTKTFLSQMR NLTSSMITNP ARQAGWKLHN
FEDSKDVLIT NFHPSMPLGL IMGVFNSVFA GYCTIFCDEE VLKTPGLLAY LITKYRCTYS
LFDYAGLKQT VYNYQEDPKS TLSFKKNYTP NLSSLKLCMV ECEVVDPEFN IIVSDRWLQP
LGTNNSKEVI TPILCLRKFG GIPISFKDWM ISYTNRQKHE RQMADTCYQE ILVLKSSIEK
EKVEIVPFLD IRKYSPNEVL CMSPFWYPIP EASVAVVNED SKNICKVGEV GEIWVYSDCL
PKLKAASVIN NPQGEQLTDY ENNQENKFEK NNSFMDSGLK GFLHNEKIFV LGNKDEQIRQ
YRKTMVADKL MEEKYVHYSH YLIKKIMKYV PEIFDGVAFE IEIDKAVYSV LVLESPIIKR
SLIRNNRLKG RDLFSELVKI TESSFQVTQD IFKLDVLSIL IAPYKSLPRS RYMGIQAINT
NKCKLAFLSG NLPVSYVRFF MDSALPKSKI NLNNSKGIWS KDASKHHREI ISLNVKQKMD
PYKHQNKVSK ARENLLNHFT ILDFLKTKSA KTPTSPAILT FNAIEKTKVE LTWAHFELKV
ASHVEYMQLS VKAKARSHIL LLYYDPLEFL ISIHSCFHLG VIPIPFQIRE ISQLIGEIEE
FTKIAKAFNV EAILVDHKVL ISLKSRDISN HFQQTCIDLN MKAPKIFETT GIPISKRAKK
ALNLITPGEL NNKGKVALIS INKLEDGSII PTQFSHSSLL AFCHEQKEFV IGNEEKPIIG
GIEFSSGMGL LHTALLGVYA GVPTLLIKQE NLCNNGSLLF EAIEQNSLSK VMIPLNICQK
SFSTAQGCNS IVINSTLSSI IVPCYDRPIS SRVNSIIEDI ARIGLAPNKV KLAYSHPINP
FVCWNADSSM EKMKDYFDAN QLRSGLVNVR EDVLRNRQPL LYGSGTSTLY NEICIVHPEE
KYICQEGEIG EIWINGKHGS YCENNELNSG CELLVQETLD KKSYSRTGQL GFIHHLKKKD
QNMEKVPVLY TLDFIWNTLE LNGLNHSVKD IEETIELVHP NICTDGCILF QASGSVVILL
EVHSQQKFAS LIPIIVATAL AAHEIILDCV AFVPKGTFLR RPTGEKRRAD ILKQWTGGDL
KHMTSYLIRQ DFLLNEDFVG TELIGTTDSY DYSDENLIIN SSQLNLL