MUG70_SCHPO
ID MUG70_SCHPO Reviewed; 730 AA.
AC O13965; Q9USF6;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Meiotically up-regulated gene 70 protein;
GN Name=mug70; ORFNames=SPAC24C9.05c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 379-536, AND SUBCELLULAR
RP LOCATION.
RC STRAIN=ATCC 38364 / 968;
RX PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA Hiraoka Y.;
RT "Large-scale screening of intracellular protein localization in living
RT fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL Genes Cells 5:169-190(2000).
RN [3]
RP FUNCTION IN MEIOSIS.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes required for
RT critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Has a role in meiosis. {ECO:0000269|PubMed:16303567}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus membrane; Multi-pass membrane
CC protein.
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DR EMBL; CU329670; CAB11262.1; -; Genomic_DNA.
DR EMBL; AB027787; BAA87091.1; -; Genomic_DNA.
DR PIR; T38346; T38346.
DR RefSeq; NP_594030.1; NM_001019455.2.
DR AlphaFoldDB; O13965; -.
DR SMR; O13965; -.
DR BioGRID; 278185; 7.
DR STRING; 4896.SPAC24C9.05c.1; -.
DR iPTMnet; O13965; -.
DR MaxQB; O13965; -.
DR PaxDb; O13965; -.
DR PRIDE; O13965; -.
DR EnsemblFungi; SPAC24C9.05c.1; SPAC24C9.05c.1:pep; SPAC24C9.05c.
DR GeneID; 2541689; -.
DR KEGG; spo:SPAC24C9.05c; -.
DR PomBase; SPAC24C9.05c; mug70.
DR VEuPathDB; FungiDB:SPAC24C9.05c; -.
DR eggNOG; ENOG502QVK2; Eukaryota.
DR HOGENOM; CLU_009026_1_1_1; -.
DR InParanoid; O13965; -.
DR OMA; IGIINMR; -.
DR PhylomeDB; O13965; -.
DR PRO; PR:O13965; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR Gene3D; 3.10.580.10; -; 2.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR000270; PB1_dom.
DR Pfam; PF00571; CBS; 4.
DR Pfam; PF00564; PB1; 1.
DR SMART; SM00116; CBS; 4.
DR SMART; SM00666; PB1; 1.
DR SUPFAM; SSF54631; SSF54631; 2.
DR PROSITE; PS51371; CBS; 4.
DR PROSITE; PS51745; PB1; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Meiosis; Membrane; Nucleus; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..730
FT /note="Meiotically up-regulated gene 70 protein"
FT /id="PRO_0000116696"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 358..378
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 706..726
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 69..127
FT /note="CBS 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 135..200
FT /note="CBS 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 263..319
FT /note="CBS 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 328..385
FT /note="CBS 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 572..649
FT /note="PB1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01081"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 730 AA; 79254 MW; A6D452F1353E4D2D CRC64;
MTVGTLSVVS STASDTASHV SDTRKRQYQR DEALRKKIIS ELGKKSGNFE SPVRKIRRNG
EPGTVDSAAL DPALTVHMQS LVTETAQLMA AKRQNCVLVV DDDEQLAGIV TATDIATRCV
GAGLNARQTL IADIMSTSPL CITSDTRFDD ALLLMIEHKF RHLPVVSDGG PDGSAGDEGD
VIGIINMRAC LREPLNRIAR QQEAAQKLVE ALEGAQEEIE NKSVSGNTNS SSVSGNHAAE
FLEYVESLKK KASGLEIMSL IDSSEEPFLV GTRTTVAEAT ESMARSGVSA VLVMDNGAVS
GVFTAHDVVL RVLAAGLDPY RSSVIRVMTP HPDCALASLR VSTALERMIE GKFSNLPVVD
ESDAIIGMLS LFHLATAIEQ TPEEEEEVFD QAENDAGIEP SNGFEDQQQQ LLGNSNEVVE
NYDVNPPLPL NPLPSNTQQS ESTYEYSARQ LPKPPVQAWQ NENLSSNNKP QEYVGVENDY
NFSNNPPTAM SEQSFHPSVS QKPMDTPENG SNSFAASPYL QPYNSASQLA PSYVGSLPQY
HGNPSFVEQA LQDLVQPTDS ASQIFPLNPQ SPSQFTIKYR SIAGRVHRLR LDGINSVSDL
RTAVEEREKE QLVTLTYIDD EGDVVELVSD SDLREAILLA RRRGLPRLEV RGVAAFTNHL
ESSHPPISTV DSSIGSASVV EKGVANSIVD IHQPTAKADK GNSKKPIYIG IVSSSIVILA
VSMWYLRRKR
