MUG80_SCHPO
ID MUG80_SCHPO Reviewed; 461 AA.
AC O14336;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=Meiotically up-regulated gene 80 protein;
GN Name=mug80; ORFNames=SPBC1D7.03;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION IN MEIOSIS.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes required for
RT critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Has a role in meiosis. {ECO:0000269|PubMed:16303567}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329671; CAB10979.1; -; Genomic_DNA.
DR PIR; T39862; T39862.
DR RefSeq; NP_595716.1; NM_001021614.2.
DR AlphaFoldDB; O14336; -.
DR SMR; O14336; -.
DR BioGRID; 277198; 212.
DR STRING; 4896.SPBC1D7.03.1; -.
DR iPTMnet; O14336; -.
DR PaxDb; O14336; -.
DR EnsemblFungi; SPBC1D7.03.1; SPBC1D7.03.1:pep; SPBC1D7.03.
DR GeneID; 2540673; -.
DR KEGG; spo:SPBC1D7.03; -.
DR PomBase; SPBC1D7.03; mug80.
DR VEuPathDB; FungiDB:SPBC1D7.03; -.
DR eggNOG; ENOG502S0QI; Eukaryota.
DR HOGENOM; CLU_593332_0_0_1; -.
DR InParanoid; O14336; -.
DR OMA; WEWWSAS; -.
DR PRO; PR:O14336; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; ISO:PomBase.
DR GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:1905412; P:negative regulation of mitotic cohesin loading; IGI:PomBase.
DR GO; GO:0016239; P:positive regulation of macroautophagy; ISO:PomBase.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0023052; P:signaling; NAS:PomBase.
DR InterPro; IPR013922; Cyclin_PHO80-like.
DR PANTHER; PTHR15615; PTHR15615; 1.
DR Pfam; PF08613; Cyclin; 1.
PE 1: Evidence at protein level;
KW Meiosis; Nucleus; Reference proteome.
FT CHAIN 1..461
FT /note="Meiotically up-regulated gene 80 protein"
FT /id="PRO_0000278613"
FT REGION 75..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 461 AA; 50623 MW; AECD3BDD40905892 CRC64;
MSFPYQHTSR SQVQPPLAAP GLSMFAPVSS SNSANSASSV AALLSHAPMY GLGQRRPSFL
PGVSVPDTLS VRSGFSIPSS SHHPSAVPSL LSQHRLQQPQ PRLYPSAPLN YYWPSYQSVP
SAAPPPPSQQ RYMPDSAVAY NPNQDQFGNS VNVSAACNNV SAPLIANNCA PSFYQSRHPV
ADVPVTNNTA TTTSETDNTI PGNLNMPSVA NVQQRISPVC KTNMEDQEET VYTGGVAAKL
DYKMDQMVEY LSIMTCKLYA RFLNNAQMHS LANSLPGLVF SFRKVVTQIL TSTRLPRASC
LLALSYLSDR LDAASQTTDF VNQWTKESLF FQICALLTTA LILANKFLDD NTFTNQSWSQ
VTGFRTALLN SFEQDWLASM SWNLSPGPRG QKAWEWWSAS YSLFTSSNAT YSGEQKTYSP
TTLSTNAPPS PSSGRSCSNC NYYYPYTPVG YYPVYNRYAM T
