MUG89_SCHPO
ID MUG89_SCHPO Reviewed; 396 AA.
AC Q1MTQ5; O94568;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Meiotically up-regulated gene 89 protein;
GN Name=mug89; ORFNames=SPBC1773.11c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-126, AND SUBCELLULAR
RP LOCATION.
RC STRAIN=ATCC 38364 / 968;
RX PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA Hiraoka Y.;
RT "Large-scale screening of intracellular protein localization in living
RT fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL Genes Cells 5:169-190(2000).
RN [3]
RP FUNCTION IN MEIOSIS.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes required for
RT critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Has a role in meiosis. {ECO:0000269|PubMed:16303567}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:16823372}; Multi-pass
CC membrane protein {ECO:0000269|PubMed:10759889,
CC ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the CDC50/LEM3 family. {ECO:0000305}.
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DR EMBL; CU329671; CAA21916.1; -; Genomic_DNA.
DR EMBL; AB028009; BAA87313.1; -; Genomic_DNA.
DR PIR; T39676; T39676.
DR RefSeq; NP_595126.1; NM_001021033.2.
DR AlphaFoldDB; Q1MTQ5; -.
DR SMR; Q1MTQ5; -.
DR BioGRID; 276466; 9.
DR STRING; 4896.SPBC1773.11c.1; -.
DR iPTMnet; Q1MTQ5; -.
DR MaxQB; Q1MTQ5; -.
DR PaxDb; Q1MTQ5; -.
DR EnsemblFungi; SPBC1773.11c.1; SPBC1773.11c.1:pep; SPBC1773.11c.
DR GeneID; 2539922; -.
DR KEGG; spo:SPBC1773.11c; -.
DR PomBase; SPBC1773.11c; mug89.
DR VEuPathDB; FungiDB:SPBC1773.11c; -.
DR eggNOG; KOG2952; Eukaryota.
DR HOGENOM; CLU_025025_0_1_1; -.
DR InParanoid; Q1MTQ5; -.
DR OMA; HLDQPYE; -.
DR PhylomeDB; Q1MTQ5; -.
DR Reactome; R-SPO-6798695; Neutrophil degranulation.
DR PRO; PR:Q1MTQ5; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; ISO:PomBase.
DR GO; GO:0005770; C:late endosome; ISO:PomBase.
DR GO; GO:1990531; C:phospholipid-translocating ATPase complex; ISO:PomBase.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0045332; P:phospholipid translocation; ISO:PomBase.
DR InterPro; IPR005045; CDC50/LEM3_fam.
DR PANTHER; PTHR10926; PTHR10926; 1.
DR Pfam; PF03381; CDC50; 1.
DR PIRSF; PIRSF015840; DUF284_TM_euk; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; Meiosis; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..396
FT /note="Meiotically up-regulated gene 89 protein"
FT /id="PRO_0000278570"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 396 AA; 44743 MW; EA7C860C50C86026 CRC64;
MPEALNENVS DTASNGPVAK TRAPPNTSFR QQRIKSWQPL LTPKIVLPLF FVLGIIFGPL
GGGLLYASSI VQELVVDYTD CETLASYDEF SAVPSKKYTA SFDQSGTIGF DKESTYWKLE
KILDKDLDMD VNYCIIRFTV PSVLKAPIFI YYRLTNFFQN HRRYAKSVDE KQLQGVALTA
DEVKGGNCFP LEVNEDDKPY YPCGLIANSL FNDTFSSLRL LDDNSVYTFS TKNIAWASDK
RRFLKTNYSP DDVAPPPNWV LRYPDGYTES NMPDLSTMEN LQVWMRTAGL PTFSKLAMRN
DNDDIFPGTY EIKIGLFFPV KSFDGTKSLV LTTRSVLGGK NPFLGIAYIV VSAVCVVLGT
VFTLRHFIRP RKLADHRYLN WDSEENNLAP HLSDRP
