ID   MUG8_SCHPO              Reviewed;         720 AA.
AC   Q10326;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Meiotically up-regulated gene 8 protein;
GN   Name=mug8; ORFNames=SPAC32A11.01;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   FUNCTION IN MEIOSIS.
RX   PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA   Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA   Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA   Smith G.R., Moreno S.;
RT   "A large-scale screen in S. pombe identifies seven novel genes required for
RT   critical meiotic events.";
RL   Curr. Biol. 15:2056-2062(2005).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Has a role in meiosis and septation.
CC       {ECO:0000269|PubMed:16303567}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC       Note=Localizes to the barrier septum.
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DR   EMBL; CU329670; CAA93698.1; -; Genomic_DNA.
DR   PIR; T38647; T38647.
DR   RefSeq; NP_593774.1; NM_001019203.2.
DR   AlphaFoldDB; Q10326; -.
DR   BioGRID; 278982; 1.
DR   STRING; 4896.SPAC32A11.01.1; -.
DR   PaxDb; Q10326; -.
DR   PRIDE; Q10326; -.
DR   EnsemblFungi; SPAC32A11.01.1; SPAC32A11.01.1:pep; SPAC32A11.01.
DR   GeneID; 2542524; -.
DR   KEGG; spo:SPAC32A11.01; -.
DR   PomBase; SPAC32A11.01; mug8.
DR   VEuPathDB; FungiDB:SPAC32A11.01; -.
DR   eggNOG; ENOG502RBV5; Eukaryota.
DR   HOGENOM; CLU_384099_0_0_1; -.
DR   InParanoid; Q10326; -.
DR   OMA; LISCLRW; -.
DR   PRO; PR:Q10326; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0032153; C:cell division site; HDA:PomBase.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR037508; Msb1/Mug8.
DR   InterPro; IPR012965; Msb1/Mug8_dom.
DR   PANTHER; PTHR28093; PTHR28093; 1.
DR   Pfam; PF08101; DUF1708; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Cytoplasm; Meiosis; Reference proteome;
KW   Septation.
FT   CHAIN           1..720
FT                   /note="Meiotically up-regulated gene 8 protein"
FT                   /id="PRO_0000116593"
SQ   SEQUENCE   720 AA;  82456 MW;  D4DD9E6FC6E5604C CRC64;
     MSRSICTLTC ILPTFSMDYW NQECVELSQV ENLFTELASR LELLEMNSKN VLYRLTIGTN
     PDRNWEAIAF IREFFDSAKH GYVIPKHEIR NRIRLLSEAS LISCLRWLLH RIPGGVITWS
     TYKLFDEAET RANYPVRGFD IFMKHATKHS CHFNILKCFL KLLMSLSAKL AVSSNSSTVS
     SLELVSQIAS IWAFDWPMMN LQETFIYWDR CTNACLRLLL CYIRYTNKSS ETGFSCLPSA
     LQSQLQSFNY PPSLKKLNDA KAHVFTFSMN YYMTRDPLEM IQIVTKMNIP DHLTATLPRS
     SDDIQNDCLF ALRQVSKRSS YHSVFSAQES AWTDFIKNGF DHPILPTCTQ ETVYSLLTGN
     DTACVYPFPN KPYRLPDVDF EIFSHCSFES LTTVTTNTNI WWVWAESRCT EIPESKRTVF
     PNCTMLIDKT GRLIILQQTV PQKPVALTAS SNKRKNRIFG KIRRSFKRIL KPRKINKTVK
     IMSNSQRRSC QSVLSEGNRT ILLHLADQMN ACSLQTKSRE SIKTLKLIEE KDEYWEPETA
     GYFNTIVGWA DQRKSLYDEA VIKINHSNML NTLPPTSQGA TSTTVSSASS NFLSSSCTPI
     DDTNSVTGST LSCSFDEMKL SDKIDDANSL KDDDFIQGSK KDFFEMNLNH SSYQNKDELK
     PFQLLVKHAF KPPSYRLIRP PLRDWQSSDT LSSEMSKSIS SSRSSPFSLE QTISKIQNKL