MUG99_SCHPO
ID MUG99_SCHPO Reviewed; 526 AA.
AC Q9P6M7;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Meiotically up-regulated gene 99 protein, mitochondrial;
DE Flags: Precursor;
GN Name=mug99; ORFNames=SPAC1610.04;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION IN MEIOSIS/SPORULATION.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes required for
RT critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Required for correct meiotic chromosome segregation. Appears
CC to also have role in sporulation. {ECO:0000269|PubMed:16303567}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
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DR EMBL; CU329670; CAB90311.1; -; Genomic_DNA.
DR RefSeq; NP_593487.1; NM_001018921.2.
DR AlphaFoldDB; Q9P6M7; -.
DR iPTMnet; Q9P6M7; -.
DR MaxQB; Q9P6M7; -.
DR PaxDb; Q9P6M7; -.
DR PRIDE; Q9P6M7; -.
DR EnsemblFungi; SPAC1610.04.1; SPAC1610.04.1:pep; SPAC1610.04.
DR GeneID; 2542794; -.
DR KEGG; spo:SPAC1610.04; -.
DR PomBase; SPAC1610.04; mug99.
DR VEuPathDB; FungiDB:SPAC1610.04; -.
DR eggNOG; ENOG502S99Q; Eukaryota.
DR HOGENOM; CLU_517917_0_0_1; -.
DR InParanoid; Q9P6M7; -.
DR OMA; MCSSSYL; -.
DR PRO; PR:Q9P6M7; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Chromosome partition; Meiosis; Membrane; Mitochondrion; Reference proteome;
KW Sporulation; Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..526
FT /note="Meiotically up-regulated gene 99 protein,
FT mitochondrial"
FT /id="PRO_0000278618"
FT TRANSMEM 398..418
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 421..441
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 526 AA; 60243 MW; 7A5D90A3AE77818F CRC64;
MLRFGIKTWK RSVLAIRRSS TAPHVQIISN LQKKLLNELY SLRRLVDDNS PATIRVGNVS
LLLSKSNIRR RIALQALSSS AEDVACVKQI THALLAAPFM PESKELKYAM DHNGLNPLYI
SFGTNALFER NARYSTSHLF LPSDFLQVNN LEIIHLPPGT VDSDILASCH ARYICSTSYL
RMTSSDFTTA DTLVLDIDPK LHSLLKNEKS IIPVSSSAAL KATKALQDDP HNFQNYQNQW
EQSGFQQLRT NMTPTSDLEI CKRFLNYLCC SFSLTKAEKD LVRATEFSNS MLISIEKWAK
YCDVDLQEFE KKLQKFWKNF GTLKLYSNIE SLPASLKQLI KDEYLQKSKL ELSFILGELS
KNGDDKNNFE LAMKDFGTFQ NSRMSAVDQA LQPLRRKTLY TTAFQGLGAL GSLYLYFVSH
FSLYNAFSVF SVCGVFGLYY LQSSYRSWKK EYWKELLEEG RKFERQLCRN VFGRSSFYVQ
QKTAAEKKEH ISLIMKKLTK TLDLMKEFQL QSSFSDSPTA SKKQLL
