ID   MUKB_ERWT9              Reviewed;        1483 AA.
AC   B2VC99;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Chromosome partition protein MukB {ECO:0000255|HAMAP-Rule:MF_01800};
DE   AltName: Full=Structural maintenance of chromosome-related protein {ECO:0000255|HAMAP-Rule:MF_01800};
GN   Name=mukB {ECO:0000255|HAMAP-Rule:MF_01800}; OrderedLocusNames=ETA_21300;
OS   Erwinia tasmaniensis (strain DSM 17950 / CFBP 7177 / CIP 109463 / NCPPB
OS   4357 / Et1/99).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Erwinia.
OX   NCBI_TaxID=465817;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17950 / CFBP 7177 / CIP 109463 / NCPPB 4357 / Et1/99;
RX   PubMed=18462403; DOI=10.1111/j.1462-2920.2008.01639.x;
RA   Kube M., Migdoll A.M., Mueller I., Kuhl H., Beck A., Reinhardt R.,
RA   Geider K.;
RT   "The genome of Erwinia tasmaniensis strain Et1/99, a non-pathogenic
RT   bacterium in the genus Erwinia.";
RL   Environ. Microbiol. 10:2211-2222(2008).
CC   -!- FUNCTION: Plays a central role in chromosome condensation, segregation
CC       and cell cycle progression. Functions as a homodimer, which is
CC       essential for chromosome partition. Involved in negative DNA
CC       supercoiling in vivo, and by this means organize and compact
CC       chromosomes. May achieve or facilitate chromosome segregation by
CC       condensation DNA from both sides of a centrally located replisome
CC       during cell division. {ECO:0000255|HAMAP-Rule:MF_01800}.
CC   -!- SUBUNIT: Homodimerization via its hinge domain. Binds to DNA via its C-
CC       terminal region. Interacts, and probably forms a ternary complex, with
CC       MukE and MukF via its C-terminal region. The complex formation is
CC       stimulated by calcium or magnesium. Interacts with tubulin-related
CC       protein FtsZ. {ECO:0000255|HAMAP-Rule:MF_01800}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC       Rule:MF_01800}. Note=Restricted to the nucleoid region.
CC       {ECO:0000255|HAMAP-Rule:MF_01800}.
CC   -!- DOMAIN: The hinge domain, which separates the large intramolecular
CC       coiled coil regions, allows the homodimerization, forming a V-shaped
CC       homodimer. {ECO:0000255|HAMAP-Rule:MF_01800}.
CC   -!- SIMILARITY: Belongs to the SMC family. MukB subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01800}.
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DR   EMBL; CU468135; CAO97176.1; -; Genomic_DNA.
DR   RefSeq; WP_012441847.1; NC_010694.1.
DR   AlphaFoldDB; B2VC99; -.
DR   SMR; B2VC99; -.
DR   STRING; 465817.ETA_21300; -.
DR   PRIDE; B2VC99; -.
DR   EnsemblBacteria; CAO97176; CAO97176; ETA_21300.
DR   KEGG; eta:ETA_21300; -.
DR   eggNOG; COG3096; Bacteria.
DR   HOGENOM; CLU_004430_0_0_6; -.
DR   OMA; FIAVYQH; -.
DR   OrthoDB; 331846at2; -.
DR   Proteomes; UP000001726; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.3500; -; 1.
DR   HAMAP; MF_01800; MukB; 1.
DR   InterPro; IPR012090; MukB.
DR   InterPro; IPR032520; MukB_hinge.
DR   InterPro; IPR042501; MukB_hinge_sf.
DR   InterPro; IPR007406; MukB_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF04310; MukB; 1.
DR   Pfam; PF16330; MukB_hinge; 1.
DR   PIRSF; PIRSF005246; MukB; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
PE   3: Inferred from homology;
KW   ATP-binding; Cell cycle; Cell division; Chromosome partition; Coiled coil;
KW   Cytoplasm; DNA condensation; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..1483
FT                   /note="Chromosome partition protein MukB"
FT                   /id="PRO_1000187477"
FT   REGION          666..783
FT                   /note="Flexible hinge"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   REGION          850..870
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          311..426
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          547..607
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          835..1115
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          1206..1266
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   BINDING         34..41
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
SQ   SEQUENCE   1483 AA;  169674 MW;  CBD2769528CD9BDC CRC64;
     MIERGKFRSL TLINWNGFFA RTFDLDELVT TLSGGNGAGK STTMAAFITA LIPDLTLLHF
     RNTTEAGATS GSRDKGLHGK LRPGVCYAAL DVVNSLHQRV IVGVRLQQIA GRDRKVDIKP
     FSIHGLPTAI NPTEILTESV SARHARVLPL SELKEKFEAM ESVQFKQYNS ITDYHSVMFD
     LGIVARRLRT AADRSKYYRL IEASLYGGIS SAITRSLRDY LLPENGGVRK AFQDMEAALR
     ENRMTLEAIR VTQSDRDLFK HLISEATNYV SADYMRHANE RRIHLDAALL LRNELFTSRK
     QRASEQYRHI EMARELAEHN AAESDLETDY QGASDHLNLV QTALRQQEKI DRYDADLEEL
     TFRLEEQNEV VAEAREVQED NEARSEAAEL EVDELKSQLA DYQQALDVQQ TRAIQYQQAL
     QALQRAQDIC QLRDLSVDNA EEWQETFQAK ELEATDKLLM LEQKMSVAQA AHSQFEQAYE
     LVTRIAGPVS RSDAWQVGRD VLRDAGNQRY HAEQLEPLRS RVSELGQRLR EQQDAERLLS
     DFCKRYGQQV DAADLENLQA ELEAQIELLN ESVADAGERR MTLRQELEQL RERIARLTKQ
     APQWLAAQEI LSQLGEQTGQ ALENSQQVTE FMQQLLERER ETTVERDDIA ARKREIERQI
     ERLSQPGGSE DARLNHLAER FGGVLLSEIY DDVTIDDAPY FSALYGPARH AIVVPDLSLI
     REQLDGLDDC PEDLYLIEGD PQSFDDSVFN VEELAKAVVV KAGDRQWRYS RFPKVPLFGR
     AARENQLEVL RAERETLAER FATLSFDVQK IQRLHQSFSR FIGSHIGVAF EPDPEAALRQ
     LNGRRNEVER ELNNHESENQ QQRQQYEQAK EGVSQLNRLL PRVSLLLDDT LQDRHEEIQE
     RLAEAQEATR FVQQHGAQLA RLEPILAVLQ SDPEQHEQLT LDYQQAQQQQ RDARQQAFAL
     TEVVQRRAHF GYIDSAGMLN GTSDLNEKLR QRLEQAEAER ARAREQLRQH QSQLTQYSQV
     LASLKSSFDA KRDMLKELQQ EMQDIGVHAD ASAEQRARLR RDELYGALSN NRARRNQLEK
     QLTFCEAEMD ALQKKLRRLE RDYQQGREQV VSAKAGWVTV LRMVKDNGVE RRLHRRELAY
     LGGDELRSMS DKALGALRLA VADNEHLRDV LRLSEDPKRP ERKIQFYIAV YQHLRERIRQ
     DIIRTDDPVE AIEQMEIELN RLTEELTARE QTLAISSRSV SNIIRKTIQR EQNRIRQLNQ
     GLQAVSFGQV KSVRLNVNVR EAHSTLLDVL SEQHEQHQDL FKSNRLTFSE ALAKLYQRLN
     PQIDMGQRTP QTIGEELLDY RNYLEMEVEV SRGSDGWLRA ESGALSTGEA IGTGMSILVM
     VVQSWEEESR RLRGKDISPC RLLFLDEAAR LDAKSIATLF ELCDRLEMQL IIAAPENISP
     EKGTTYKLVR KVFNNTEHVH VVGLRGFSAE PGAATGSADV GAH