ID   MUKB_GLAP5              Reviewed;        1496 AA.
AC   B8F3Q0;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Chromosome partition protein MukB {ECO:0000255|HAMAP-Rule:MF_01800};
DE   AltName: Full=Structural maintenance of chromosome-related protein {ECO:0000255|HAMAP-Rule:MF_01800};
GN   Name=mukB {ECO:0000255|HAMAP-Rule:MF_01800}; OrderedLocusNames=HAPS_0263;
OS   Glaesserella parasuis serovar 5 (strain SH0165) (Haemophilus parasuis).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Glaesserella.
OX   NCBI_TaxID=557723;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SH0165;
RX   PubMed=19074396; DOI=10.1128/jb.01682-08;
RA   Yue M., Yang F., Yang J., Bei W., Cai X., Chen L., Dong J., Zhou R.,
RA   Jin M., Jin Q., Chen H.;
RT   "Complete genome sequence of Haemophilus parasuis SH0165.";
RL   J. Bacteriol. 191:1359-1360(2009).
CC   -!- FUNCTION: Plays a central role in chromosome condensation, segregation
CC       and cell cycle progression. Functions as a homodimer, which is
CC       essential for chromosome partition. Involved in negative DNA
CC       supercoiling in vivo, and by this means organize and compact
CC       chromosomes. May achieve or facilitate chromosome segregation by
CC       condensation DNA from both sides of a centrally located replisome
CC       during cell division. {ECO:0000255|HAMAP-Rule:MF_01800}.
CC   -!- SUBUNIT: Homodimerization via its hinge domain. Binds to DNA via its C-
CC       terminal region. Interacts, and probably forms a ternary complex, with
CC       MukE and MukF via its C-terminal region. The complex formation is
CC       stimulated by calcium or magnesium. Interacts with tubulin-related
CC       protein FtsZ. {ECO:0000255|HAMAP-Rule:MF_01800}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC       Rule:MF_01800}. Note=Restricted to the nucleoid region.
CC       {ECO:0000255|HAMAP-Rule:MF_01800}.
CC   -!- DOMAIN: The hinge domain, which separates the large intramolecular
CC       coiled coil regions, allows the homodimerization, forming a V-shaped
CC       homodimer. {ECO:0000255|HAMAP-Rule:MF_01800}.
CC   -!- SIMILARITY: Belongs to the SMC family. MukB subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01800}.
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DR   EMBL; CP001321; ACL31952.1; -; Genomic_DNA.
DR   RefSeq; WP_012621638.1; NC_011852.1.
DR   AlphaFoldDB; B8F3Q0; -.
DR   SMR; B8F3Q0; -.
DR   STRING; 557723.HAPS_0263; -.
DR   EnsemblBacteria; ACL31952; ACL31952; HAPS_0263.
DR   KEGG; hap:HAPS_0263; -.
DR   PATRIC; fig|557723.8.peg.270; -.
DR   HOGENOM; CLU_004430_0_0_6; -.
DR   OMA; FIAVYQH; -.
DR   Proteomes; UP000006743; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.3500; -; 1.
DR   HAMAP; MF_01800; MukB; 1.
DR   InterPro; IPR012090; MukB.
DR   InterPro; IPR032520; MukB_hinge.
DR   InterPro; IPR042501; MukB_hinge_sf.
DR   InterPro; IPR007406; MukB_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF04310; MukB; 1.
DR   Pfam; PF16330; MukB_hinge; 1.
DR   PIRSF; PIRSF005246; MukB; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell cycle; Cell division; Chromosome partition; Coiled coil;
KW   Cytoplasm; DNA condensation; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..1496
FT                   /note="Chromosome partition protein MukB"
FT                   /id="PRO_1000187479"
FT   REGION          694..811
FT                   /note="Flexible hinge"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          326..492
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          534..632
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          863..942
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          1005..1171
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          1235..1291
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   BINDING         62..69
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
SQ   SEQUENCE   1496 AA;  171744 MW;  8FA763645FD2EBCD CRC64;
     MTEKNDLFEQ NVTSQNIMVA THVQSSIPSV SRSKFRSLTL INWNGFFART FDLDELVTTL
     SGGNGAGKST TMAGFVTALI PDLTLLNFRN TTEAGSTSSS RDKGLYGKLK AGVCYAVLES
     ENSRGQRVIS GVRLQQIAGR DKKVDIRSFS LQNINENQSV ISILTEQVGE KNARVLALND
     LKEKFDGSEV QFKQYHSITD YHSFLFDLGV IPKRLRTSGD RSKFYKLIEA SLYGGISSVI
     TKSLRDYLLP ENTGVRQAFQ DMESALRENR MTLEAIKVTQ SDRDMFKKLI TESTNYVSAD
     YMRHANERRG NVQQAIEKRQ EWYQSKSKLT LEQQRLVEFS REMQDLEQGE SSLEAEYNSA
     SDHLNLVMNA VRHQEKVERY QDDVAELNER LEEQQMALEE VAERQEMAQA RATEAEDQVE
     ELRSQMADYQ QALDAQQTRA LQYQQAVNAL EKAKQISGLA NLDLHNVEDY HAEFVAQADE
     ITDKVFELEQ RLSVSDMAKS QFDKAYELVC KIAGETDRLQ ADSVARELLS AYPSQKAHAQ
     QAVALRQKLT ELEQRLHQQQ NAERLLAEFN QKAQAELENA EDLESYYEEQ QARLEDLEAE
     LAEFVEVRST QRQQREQLNQ QYQQLAQTAP AWHTAQSALA RLQEQCGETF DSSQAVMQFM
     QNTLSREREA TLERDELARR EQLLDEQISR LSQPDGAEDI RLNQLAEKFG GVLISELYED
     VSIEDAPYFS ALYGDARHAI VVRNLEAVKA QLQQLDDCPE NLYLIEGDPN AFDDNVFKSE
     ELGDGVVVQL SDRQWRYSKF SEFAVFGRAS REKQLEKVKA ERDETTEKHA ERAFDVQKCQ
     RLHQHLSQFV GTHLALAFQP DPEVAMQEIA QKRAEIEREL NQASGTEQQL RHQLENSKAQ
     LQLLNKVLPQ LNILADETLQ DRVEECREQL LEAQEDEQFI RQFGNALAQL EPIAVALKSD
     PTQFEQLQAD YKRSVEQQKL QQQKVFALAD VMNRRLHFSY QETVGAEGSA LNEQLRQRLD
     NAQREREQAR EQLRQATAQF SEYNQVLTSL RSAFDAKNQM LQELLQEMDE YGIRNDDGAE
     ERARIRRDEL QQRLSQHRMR KSYIDKQVAV IQAEMDNLNK AVRKAERDYH TQREIVVQAK
     VSWCLVLKLS RNSDVEKRLN RRELAYQSAE ELRSISDKAL GALRTAVADN EYLRDSLRAS
     EDSRKPENKV VFFILVYQHL RERIRQDIIK TDDPIDAIEQ MEIELSRLTN ELTSREKKLA
     ISSESVANIL RKTIQREQNR ILQLNQGLQN IAFGQVKGVR LVVNIRDTHA ILLNALSNDR
     EQHSDLFENQ KLSFSEALAM LYKRVNPHIE LGQRTPQTIG EELLDYRNYL DLEVETFRGA
     DGWMRAESSA LSTGEAIGTG MSILLMVVQS WEEESRRMRA KDILPARLLF LDEAARLDAT
     SINTLFELCE RLDMQLLIAA PENISPERGT TYKLVRKITN NQEYVHVVGL KGFGRV