ID   MUKB_HAEAE              Reviewed;         190 AA.
AC   O68583;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Chromosome partition protein MukB;
DE   AltName: Full=Structural maintenance of chromosome-related protein;
DE   Flags: Fragment;
GN   Name=mukB;
OS   Haemophilus aegyptius.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=197575;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 11116 / CCUG 25716 / NCTC 8502 / 180-a;
RA   Zhang B.-H., Wilson G.G.;
RL   Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a central role in chromosome condensation, segregation
CC       and cell cycle progression. Functions as a homodimer, which is
CC       essential for chromosome partition. Involved in negative DNA
CC       supercoiling in vivo, and by this means organize and compact
CC       chromosomes. May achieve or facilitate chromosome segregation by
CC       condensation DNA from both sides of a centrally located replisome
CC       during cell division (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimerization via its hinge domain. Binds to DNA via its C-
CC       terminal region. Interacts, and probably forms a ternary complex, with
CC       MukE and MukF via its C-terminal region. The complex formation is
CC       stimulated by calcium or magnesium. Interacts with tubulin-related
CC       protein FtsZ (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000250}.
CC       Note=Restricted to the nucleoid region. {ECO:0000250}.
CC   -!- DOMAIN: The hinge domain, which separates the large intramolecular
CC       coiled coil regions, allows the homodimerization, forming a V-shaped
CC       homodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SMC family. MukB subfamily. {ECO:0000305}.
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DR   EMBL; AF051375; AAC05698.1; -; Genomic_DNA.
DR   AlphaFoldDB; O68583; -.
DR   SMR; O68583; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Chromosome partition; Cytoplasm;
KW   DNA condensation; DNA-binding.
FT   CHAIN           <1..190
FT                   /note="Chromosome partition protein MukB"
FT                   /id="PRO_0000068218"
FT   NON_TER         1
SQ   SEQUENCE   190 AA;  21359 MW;  71EB8803BCBDFBC5 CRC64;
     THAMLLDALS GQQDEYQDLF NDNRITFSEA MAKLYQRINP HIDMGQRTAQ TIGEELLDYR
     NYLELEVEVF RGADGWLRAE SGALSTGEAI GTGMSILLMV VQSWEEESRR IRGKDIVPCR
     LLFLDEAARL DGKSISTLFE LCERLDMQLL IAAPENISPE KGTTYKLVRK IAGNQEHVHV
     VGLRGFGATE