ID   MUKB_HAEI8              Reviewed;        1510 AA.
AC   Q4QK86;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Chromosome partition protein MukB {ECO:0000255|HAMAP-Rule:MF_01800};
DE   AltName: Full=Structural maintenance of chromosome-related protein {ECO:0000255|HAMAP-Rule:MF_01800};
GN   Name=mukB {ECO:0000255|HAMAP-Rule:MF_01800}; OrderedLocusNames=NTHI1784;
OS   Haemophilus influenzae (strain 86-028NP).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=281310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=86-028NP;
RX   PubMed=15968074; DOI=10.1128/jb.187.13.4627-4636.2005;
RA   Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B.,
RA   Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O.,
RA   Munson R.S. Jr.;
RT   "Genomic sequence of an otitis media isolate of nontypeable Haemophilus
RT   influenzae: comparative study with H. influenzae serotype d, strain KW20.";
RL   J. Bacteriol. 187:4627-4636(2005).
CC   -!- FUNCTION: Plays a central role in chromosome condensation, segregation
CC       and cell cycle progression. Functions as a homodimer, which is
CC       essential for chromosome partition. Involved in negative DNA
CC       supercoiling in vivo, and by this means organize and compact
CC       chromosomes. May achieve or facilitate chromosome segregation by
CC       condensation DNA from both sides of a centrally located replisome
CC       during cell division. {ECO:0000255|HAMAP-Rule:MF_01800}.
CC   -!- SUBUNIT: Homodimerization via its hinge domain. Binds to DNA via its C-
CC       terminal region. Interacts, and probably forms a ternary complex, with
CC       MukE and MukF via its C-terminal region. The complex formation is
CC       stimulated by calcium or magnesium. Interacts with tubulin-related
CC       protein FtsZ. {ECO:0000255|HAMAP-Rule:MF_01800}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC       Rule:MF_01800}. Note=Restricted to the nucleoid region.
CC       {ECO:0000255|HAMAP-Rule:MF_01800}.
CC   -!- DOMAIN: The hinge domain, which separates the large intramolecular
CC       coiled coil regions, allows the homodimerization, forming a V-shaped
CC       homodimer. {ECO:0000255|HAMAP-Rule:MF_01800}.
CC   -!- SIMILARITY: Belongs to the SMC family. MukB subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01800}.
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DR   EMBL; CP000057; AAX88561.1; -; Genomic_DNA.
DR   RefSeq; WP_011272629.1; NC_007146.2.
DR   AlphaFoldDB; Q4QK86; -.
DR   SMR; Q4QK86; -.
DR   PRIDE; Q4QK86; -.
DR   EnsemblBacteria; AAX88561; AAX88561; NTHI1784.
DR   KEGG; hit:NTHI1784; -.
DR   HOGENOM; CLU_004430_0_0_6; -.
DR   OMA; FIAVYQH; -.
DR   OrthoDB; 331846at2; -.
DR   Proteomes; UP000002525; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.3500; -; 1.
DR   HAMAP; MF_01800; MukB; 1.
DR   InterPro; IPR012090; MukB.
DR   InterPro; IPR032520; MukB_hinge.
DR   InterPro; IPR042501; MukB_hinge_sf.
DR   InterPro; IPR007406; MukB_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF04310; MukB; 1.
DR   Pfam; PF16330; MukB_hinge; 1.
DR   PIRSF; PIRSF005246; MukB; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
PE   3: Inferred from homology;
KW   ATP-binding; Cell cycle; Cell division; Chromosome partition; Coiled coil;
KW   Cytoplasm; DNA condensation; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..1510
FT                   /note="Chromosome partition protein MukB"
FT                   /id="PRO_1000069908"
FT   REGION          707..824
FT                   /note="Flexible hinge"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          6..30
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          346..506
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          553..633
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          673..706
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          821..847
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          876..1064
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          1094..1149
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          1249..1305
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   BINDING         75..82
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
SQ   SEQUENCE   1510 AA;  173437 MW;  C12D3818BB9F88C8 CRC64;
     MSDVFELENE IELESDEVIM ENENVEEIVD APMPFSMTTN NGVERGKFRS LTLINWNGFF
     ARTFDLDELV TTLSGGNGAG KSTTMAGFVT ALIPDLTLLH FRNTTEAGST GGSRDKGLHG
     KLRPGVCYAV LDTINSRHQR ILVGVRLQQI AGRDKKVDLK TFSIQGVELS QNPTALFTET
     VGERQARVLN LNELKDKIEN IGAQFKQYHS ITDYHGMMFD LGIIPKRLRS ASDRSKFYKL
     IEASLYGGIS SAITRSLRDY LLPENLGVRK AFQDMESALR ENRMTLEAIK VTQSDRNLFK
     HLITETTNYV ASDYMRNANE RRGNIEAALE SRREWYKAKA EQNLSQHRLV DLSREAAELA
     ENERTLEVDH QSAVDHLNLV LNALRHQEKI TRYQEDIAEL TERLEEQKIV VEDANDALEE
     SQAQFEQTEI EIDAVRAQLA DYQQALDAQQ TRALQYQQAI TALEKAKTLC GLADLSVKNV
     EDYHAEFEAH AESLTETVLE LEHKMSISEA AKSQFDKAYQ LVCKIAGEIP RSSAWESAKE
     LLREYPSQKL QAQQTPQLRT KLHELEQRYA QQQSAVKLLN DFNQRANLSL QTAEELEDYH
     AEQEALIEDI SARLSEQVEN RSTLRQKREN LTALYDENAR KAPAWLTAQA ALERLEQQSG
     ETFEHSQDVM NFMQSQLVKE RELTMQRDQL EQKRLQLDEQ ISRLSQPDGS EDPRLNMLAE
     RFGGVLLSEL YDDVTIEDAP YFSALYGPAR HAIVVRDLNA VREQLAQLED CPDDLYLIEG
     DPTAFDDSVL SAQELELGVV VQVSDRELRY SRFPEIPLFG RAAREKRLEE LQIERDEVAE
     QYAQIAFDVQ KCQRLHEHFS QFVGLHLALA FQPNPEELMS EINRERNEID RELNQFNNGE
     QQLRIQLDNA KEKLQLLNKL IPQLNVLTDE DLIDRIEECR EQLDIAEQDE YFIRQYGVTL
     SQLEPIANSL QSDPENYDGL KNELTQAIER QKQVQQRVFA LADVVQRKHH FGYEDAGQAK
     TSELNEKLRQ RLEQMQAQRD MQREQVRQKQ SQFAEYNRVL IQLQSSYDSK YQLLNELISE
     ISDLGVRADD GAEERARIRR DELHQQLSTS RQRRSYVEKQ LTLIESEADN LNRLIRKTER
     DYKTQRELVV AAKVSWCVVL RLSRNSDMEK RLNRRELAYL SADELRSMSD KALGALRTAV
     ADNEYLRDSL RVSEDSRKPE NKVRFFIAVY QHLRERIRQD IIKTDDPIDA IEQMEIELSR
     LTAELTGREK KLAISSESVA NIMRKTIQRE QNRIRMLNQG LQNISFGQVK SVRLVVNIRD
     THAMLLDALS GQQDEYQDLF NDNCITFSEA MAKLYQRINP HIDMGQRTAQ TIGEELLDYR
     NYLELEVEVF RGADGWLRAE SGALSTGEAI GTGMSILLMV VQSWEEESRR IRGKDIVPCR
     LLFLDEAARL DGKSISTLFE LCERLDMQLL IAAPENISPE KGTTYKLVRK IAGNQEHVHV
     VGLRGFGATE