ID   MUKB_HAEIG              Reviewed;        1510 AA.
AC   A5UEK8;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Chromosome partition protein MukB {ECO:0000255|HAMAP-Rule:MF_01800};
DE   AltName: Full=Structural maintenance of chromosome-related protein {ECO:0000255|HAMAP-Rule:MF_01800};
GN   Name=mukB {ECO:0000255|HAMAP-Rule:MF_01800};
GN   OrderedLocusNames=CGSHiGG_00570;
OS   Haemophilus influenzae (strain PittGG).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=374931;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PittGG;
RX   PubMed=17550610; DOI=10.1186/gb-2007-8-6-r103;
RA   Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C.,
RA   Ehrlich G.D.;
RT   "Characterization and modeling of the Haemophilus influenzae core and
RT   supragenomes based on the complete genomic sequences of Rd and 12 clinical
RT   nontypeable strains.";
RL   Genome Biol. 8:R103.1-R103.18(2007).
CC   -!- FUNCTION: Plays a central role in chromosome condensation, segregation
CC       and cell cycle progression. Functions as a homodimer, which is
CC       essential for chromosome partition. Involved in negative DNA
CC       supercoiling in vivo, and by this means organize and compact
CC       chromosomes. May achieve or facilitate chromosome segregation by
CC       condensation DNA from both sides of a centrally located replisome
CC       during cell division. {ECO:0000255|HAMAP-Rule:MF_01800}.
CC   -!- SUBUNIT: Homodimerization via its hinge domain. Binds to DNA via its C-
CC       terminal region. Interacts, and probably forms a ternary complex, with
CC       MukE and MukF via its C-terminal region. The complex formation is
CC       stimulated by calcium or magnesium. Interacts with tubulin-related
CC       protein FtsZ. {ECO:0000255|HAMAP-Rule:MF_01800}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC       Rule:MF_01800}. Note=Restricted to the nucleoid region.
CC       {ECO:0000255|HAMAP-Rule:MF_01800}.
CC   -!- DOMAIN: The hinge domain, which separates the large intramolecular
CC       coiled coil regions, allows the homodimerization, forming a V-shaped
CC       homodimer. {ECO:0000255|HAMAP-Rule:MF_01800}.
CC   -!- SIMILARITY: Belongs to the SMC family. MukB subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01800}.
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DR   EMBL; CP000672; ABQ99213.1; -; Genomic_DNA.
DR   AlphaFoldDB; A5UEK8; -.
DR   SMR; A5UEK8; -.
DR   EnsemblBacteria; ABQ99213; ABQ99213; CGSHiGG_00570.
DR   KEGG; hiq:CGSHiGG_00570; -.
DR   HOGENOM; CLU_004430_0_0_6; -.
DR   OMA; FIAVYQH; -.
DR   Proteomes; UP000001990; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.70.3500; -; 1.
DR   HAMAP; MF_01800; MukB; 1.
DR   InterPro; IPR012090; MukB.
DR   InterPro; IPR032520; MukB_hinge.
DR   InterPro; IPR042501; MukB_hinge_sf.
DR   InterPro; IPR007406; MukB_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF04310; MukB; 1.
DR   Pfam; PF16330; MukB_hinge; 1.
DR   PIRSF; PIRSF005246; MukB; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
PE   3: Inferred from homology;
KW   ATP-binding; Cell cycle; Cell division; Chromosome partition; Coiled coil;
KW   Cytoplasm; DNA condensation; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..1510
FT                   /note="Chromosome partition protein MukB"
FT                   /id="PRO_1000069909"
FT   REGION          707..824
FT                   /note="Flexible hinge"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          6..30
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          346..506
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          553..611
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          673..706
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          821..846
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          876..1064
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          1094..1149
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   COILED          1249..1304
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
FT   BINDING         75..82
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01800"
SQ   SEQUENCE   1510 AA;  173185 MW;  03E286CFB146D163 CRC64;
     MSDVFELENE IELESDEVIM ENENVEEIVD APIPFSMTTN NGVERGKFRS LTLINWNGFF
     ARTFDLDELV TTLSGGNGAG KSTTMAGFVT ALIPDLTLLH FRNTTEAGST GGSRDKGLHG
     KLRPGVCYAV LDTINSRHQR ILVGVRLQQI AGRDKKVDLK TFSIQGVELS QNPTALFTET
     VGERQARVLN LNELKDKIEN IGAQFKQYHS ITDYHGMMFD LGIIPKRLRS ASDRSKFYKL
     IEASLYGGIS SAITRSLRDY LLPENLGVRK AFQDMESALR ENRMTLEAIK VTQSDRDLFK
     HLITETTNYV ASDYMRNANE RRGNIEAALE SRREWYKAKA EQNLSQHRLV DLSREAAELA
     ENERTLEVDH QSAVDHLNLV LNALRHQEKI TRYQEDIAEL TERLEEQKMV VEDANDALEE
     SQAQFEQTEI EIDAVRAQLA DYQKALDAQQ TRALQYQQAI AALEKAKTLC GLADLSVKNV
     EDYHAEFEAH AESLTETVLE LEHKMSISEA AKSQFDKAYQ LVCKIAGEMP RSAAWESAKE
     LLREYPSQKL QAQQTPQLRT KLHELEQRYA QQQSAVKLLN DFNQRTNLSL QTAEELEDYH
     AEQEALIEDI SAGLSEQVEN RSTLRQKREN LTALYDENAR KAPAWLTAQA ALERLEQQSG
     ETFEHSQDVM NFMQSQLVKE RELTMQRDQL EQKRLQLDEQ ISRLSQPDGS EDPRLNMLAE
     RFGGVLLSEL YDDVTIEDAP YFSALYGPSR HAIVVRDLNA VREQLAQLED CPDDLYLIEG
     DPTAFDDSVL SAQELELGVV VQVSDRELRY SRFPEIPLFG SAAREKRLEE LQIERDEVAE
     QHAQIAFDVQ KYQRLHEHFS QFVGLHLALA FQPNPEALMS EINRERNEID RELNQFNNGE
     QQLRIQLDNA KEKLQLLNKL IPQLNVLADE DLIDRIEECR EQLDIAEQDE YFIRQYGVTL
     SQLEPIANSL QSDPENYEGL KNELTQAIER QKQVQQRVFA LADVVQRKPH FGYEDAGQAE
     TSELNEKLRQ RLEQMQAQRD TQREQVRQKQ SQFAEYNRVL IQLQSSYDSK YQLLNELIGE
     ISDLGVRADD GAEERARIRR DELHQQLSTS RQRRSYVEKQ LTLIESEADN LNRLIRKTER
     DYKTQRELVV AAKVSWCVVL RLSRNSDMEK RLNRRELAYL SADELRSMSD KALGALRTAV
     ADNEYLRDSL RVSEDSRKPE NKVRFFIAVY QHLRERIRQD IIKTDDPIDA IEQMEIELSR
     LTAELTGREK KLAISSESVA NIMRKTIQRE QNRIRMLNQG LQNIAFGQVK SVRLVVNIRD
     THAMLLDALS GQQNEYQDLF NDNRITFSEA MAKLYQRINP HIDMGQRTAQ TIGEELLDYR
     NYLELEVEVF RGADGWLRAE SGALSTGEAI GTGMSILLMV VQSWEEESRR IRGKDIVPCR
     LLFLDEAARL DGKSISTLFE LCERLDMQLL IAAPENISPE KGTTYKLVRK IAGNQEHVHV
     VGLRGFGATE